2024
An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvementReductions in Anxiety are Associated with Decreased Expressive Suppression and Increased Cognitive Reappraisal After Cognitive-Behavioral Treatment: A Naturalistic Study in Youth
Knowles K, Tolin D. Reductions in Anxiety are Associated with Decreased Expressive Suppression and Increased Cognitive Reappraisal After Cognitive-Behavioral Treatment: A Naturalistic Study in Youth. Child Psychiatry & Human Development 2024, 1-8. PMID: 38530590, DOI: 10.1007/s10578-024-01684-4.Peer-Reviewed Original ResearchCognitive-behavioral therapyObsessive-compulsive disorderCognitive reappraisalExpressive suppressionAnxious youthSessions of cognitive-behavioral therapyEmotion regulation strategy usePrimary obsessive-compulsive disorderObsessive-compulsive disorder symptomsRegulation strategy useCognitive-behavioral treatmentTreatment-seeking sampleAnxiety-related disordersEmotion regulation strategiesEmotion regulation abilitiesEmotion regulation skillsMeasures of anxietyPost-treatment anxietyAssociated with anxiety reductionAnxiety disordersCognitive-behavioralEmotion regulationBroad deficitsRegulation skillsNaturalistic studyAn investigation of the role of estradiol in fear reduction during a single session of exposure therapy
Levy H, Mullins J, Tolin D. An investigation of the role of estradiol in fear reduction during a single session of exposure therapy. Cognitive Behaviour Therapy 2024, 53: 364-376. PMID: 38299480, DOI: 10.1080/16506073.2024.2313743.Peer-Reviewed Original ResearchObsessive-compulsive disorderExposure therapyAnxiety disordersPrimary obsessive-compulsive disorderSubjective distress ratingsAnxiety specialty clinicLow estradiol groupFear extinctionSubjective distressFear reductionExposure sessionsBrief delayDistress ratingsRecall delayAnxietyTherapy researchExposure outcomesDisordersSpecialty clinicsHigher estradiolDistressPrimary diagnosisEndogenous estradiolRecallEstradiol group
2023
Combining Pharmacotherapy and Psychological Treatments for Obsessive-Compulsive Disorder
Tolin D, Sain K. Combining Pharmacotherapy and Psychological Treatments for Obsessive-Compulsive Disorder. 2023, 557-583. DOI: 10.1093/oxfordhb/9780190068752.013.21.Peer-Reviewed Original ResearchCognitive behavioral therapyObsessive-compulsive disorderD-cycloserineFirst-line monotherapyEffective monotherapyCombined therapyMedication monotherapyMonotherapyFirst treatmentSystematic reviewCBT monotherapyTherapyPsychological treatmentCompulsive disorderPharmacotherapyTreatmentMeta-analytic strategyBiological mechanismsDisordersEfficacyPlaceboMedicationsPatientsThe DIAMOND-KID: Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders in Children and Adolescents
Tolin D, Sain K, Davis E, Gilliam C, Hannan S, Springer K, Stubbing J, George J, Jean A, Goldblum R, Katz B, Everhardt K, Darrow S, Ohr E, Young M, Serchuk M. The DIAMOND-KID: Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders in Children and Adolescents. Assessment 2023, 30: 2351-2363. PMID: 36632642, DOI: 10.1177/10731911221143994.Peer-Reviewed Original ResearchConceptsSelf-report measuresDiagnostic InterviewSemi-structured diagnostic interviewObsessive-compulsive disorderGeneralized anxiety disorderSymptoms of anxietyDSM-5 AnxietyPediatric psychiatric disordersTest-retest reliability dataDisorder childrenAdolescent versionTest-retest reliabilityObsessive-CompulsiveAnxiety disordersConvergent validitySemi-structured interviewsQuestionable rangePsychometric propertiesAnxietyMoodRelated disordersInterrater reliability dataInitial interviewParents/guardiansGroup comparisonsObsessive-compulsive disorder
Stubbing J, Tolin D. Obsessive-compulsive disorder. 2023, 673-682. DOI: 10.1016/b978-0-323-91497-0.00260-5.Peer-Reviewed Original ResearchObsessive-compulsive disorder
2022
Co-occurring Obsessive-Compulsive Disorder and Hoarding Disorder: A Review of the Current Literature.
Worden B, Tolin D. Co-occurring Obsessive-Compulsive Disorder and Hoarding Disorder: A Review of the Current Literature. Journal Of Cognitive Psychotherapy 2022, 36: 271-286. PMID: 36635053, DOI: 10.1891/jcp-2021-0010.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderContext of OCDCognitive behavioral therapyCo-occurring obsessive-compulsive disorderResponse preventionHoarding DisorderHoarding symptomsOCD symptomsAnxiety symptomsTheoretical conceptualizationBelief patternsDifferential diagnosisTic disordersCurrent researchConceptualizationDisordersPhenomenological aspectsComorbidity profilesEtiological factorsTreatment protocolSymptoms
2021
Hoarding Disorder
Worden B, Tolin D. Hoarding Disorder. 2021, 63-86. DOI: 10.1093/med-psych/9780190052775.003.0005.Peer-Reviewed Original Research
2018
Change in obsessive beliefs in therapist-directed and self-directed exposure therapy for obsessive-compulsive disorder
Levy H, Hannan S, Diefenbach G, Tolin D. Change in obsessive beliefs in therapist-directed and self-directed exposure therapy for obsessive-compulsive disorder. Journal Of Obsessive-Compulsive And Related Disorders 2018, 18: 1-7. DOI: 10.1016/j.jocrd.2018.05.001.Peer-Reviewed Original ResearchObsessive-compulsive disorderCognitive-behavioral theorySelf-directed treatmentObsessive beliefsMaladaptive beliefsExposure therapyGreater cognitive changeExposure-based treatmentsSelf-directed conditionMechanisms of changeLinear growth modelingStand-alone interventionCognitive changesSuperior treatment outcomesGrowth modelingBeliefsCurrent studyBelief changeTreatment conditionsTreatment outcomesDisordersTreatment effectsDisconfirmationStimuliTherapistsObsessive-compulsive and related disorders.
Tolin D, Springer K. Obsessive-compulsive and related disorders. 2018, 455-479. DOI: 10.1037/0000064-019.Peer-Reviewed Original ResearchObsessive-compulsive disorderCognitive behavioral therapyBody dysmorphic disorderFifth editionPsychological modelsDysmorphic disorderReview researchDSM-5First-line interventionRelated disordersExcoriation disorderStatistical ManualOCRDsSomatic treatmentsDisordersTreatment outcomesSubstantial evidenceCompulsionObsessionTrichotillomaniaSymptomsAssociated burdenEditionInterventionClear need
2015
Comorbidity in Hoarding Disorder
Frost R, Steketee G, Tolin D. Comorbidity in Hoarding Disorder. FOCUS The Journal Of Lifelong Learning In Psychiatry 2015, 13: 244-251. DOI: 10.1176/appi.focus.130218.Peer-Reviewed Original ResearchMajor depressive disorderObsessive-compulsive disorderImpulse control disordersControl disordersRates of MDDRate of OCDHD participantsHigh comorbidity ratesParticipants meeting criteriaSpecific anxiety disordersSerious methodological shortcomingsPsychiatric comorbiditySample of peopleDepressive disorderComorbidity patternsComorbidity ratesMeeting criteriaComorbiditiesDistinct disordersAnxiety disordersLarge-scale studiesDisordersHoarding DisorderInattentive ADHDCompulsive disorder
2014
Obsessive-compulsive disorder in adults.
Worden B, Tolin D. Obsessive-compulsive disorder in adults. 2014, 13-35. DOI: 10.1037/14323-002.Peer-Reviewed Original ResearchSelf-help formatTypes of obsessionsObsessive-compulsive disorderCognitive processesCognitive therapyResponse preventionCognitive aspectsGroup therapyPsychotherapeutic treatmentOCDPsychotherapy researchBehavioral aspectsBelief systemsFuture directionsRitualizingObsessionAvoidanceAdultsAspectsDisordersBrief reviewResearchSuggestionsChapter
2012
D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report
Norberg M, Gilliam C, Villavicencio A, Pearlson G, Tolin D. D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report. Cognitive And Behavioral Practice 2012, 19: 338-345. DOI: 10.1016/j.cbpra.2011.05.002.Peer-Reviewed Original ResearchObsessive-compulsive disorderN-methyl-D-aspartate (NMDA) receptor partial agonist D-cycloserinePartial agonist D-cycloserineThird of patientsD-cycloserineCourse of ERPReuptake inhibitorsCase reportTreatment nonrespondersEffective treatmentPatientsPrior treatmentResponse preventionGreater reductionTreatmentDisordersPresent studyAdequate responseNonrespondersPrevention
2010
Insight-Related Challenges in the Treatment of Hoarding
Frost R, Tolin D, Maltby N. Insight-Related Challenges in the Treatment of Hoarding. Cognitive And Behavioral Practice 2010, 17: 404-413. DOI: 10.1016/j.cbpra.2009.07.004.Peer-Reviewed Original ResearchHow Are Dysfunctional Beliefs Related to Obsessive-Compulsive Symptoms?
Taylor S, Coles M, Abramowitz J, Wu K, Olatunji B, Timpano K, McKay D, Kim S, Carmin C, Tolin D. How Are Dysfunctional Beliefs Related to Obsessive-Compulsive Symptoms? Journal Of Cognitive Psychotherapy 2010, 24: 165-176. DOI: 10.1891/0889-8391.24.3.165.Peer-Reviewed Original ResearchTypes of beliefsObsessive-compulsive disorderDysfunctional beliefsOC symptomsContemporary cognitive modelsIntolerance of uncertaintyOverestimation of threatLarge nonclinical sampleObsessive-compulsive symptomsStructural equation modelingCognitive modelObsessivecompulsive symptomsPrevious theorizingNonclinical sampleWashing compulsionsEquation modelingPersonal responsibilityBeliefsThoughtResearch designOverimportancePerfectionismSymptomsSymptom dataCompulsionCompulsions
Tolin D. Compulsions. 2010, 1-3. DOI: 10.1002/9780470479216.corpsy0210.Peer-Reviewed Original Research
2007
Obsessional Beliefs and Symptoms of Obsessive–Compulsive Disorder in a Clinical Sample
Tolin D, Brady R, Hannan S. Obsessional Beliefs and Symptoms of Obsessive–Compulsive Disorder in a Clinical Sample. Journal Of Psychopathology And Behavioral Assessment 2007, 30: 31-42. DOI: 10.1007/s10862-007-9076-7.Peer-Reviewed Original ResearchImportance/controlObsessional beliefsCertainty beliefsOCD patientsResponsibility/threat estimationObsessive-compulsive disorder symptomsObsessive Beliefs QuestionnairePerfectionism/certaintyFear/threatOCD symptom dimensionsHierarchical regression analysisObsessive-Compulsive InventoryObsessive-compulsive disorderAdult OCD patientsThreat estimationDisorder symptomsComorbid symptomsSymptom dimensionsClinical samplesBeliefs QuestionnaireBeliefsDoubtingThoughtRegression analysisSymptomsGeneral Issues in Psychological Treatment for Obsessive-Compulsive Disorder.
Tolin D, Steketee G. General Issues in Psychological Treatment for Obsessive-Compulsive Disorder. 2007, 31-59. DOI: 10.1037/11543-002.Peer-Reviewed Original ResearchObsessive-compulsive disorderCognitive therapyPsychological treatmentAvoidance behaviorDecision makingNegative emotionsIntrusive thoughtsResponse preventionMotivational strategiesObsessive thoughtsOCD symptomsCompulsive disorderExposure treatmentProbability of harmERPImplementation of interventionsSerotonergic medicationsResearch findingsTreatment targetsOwn gainInfluence of comorbiditiesClinician decision makingThoughtEmotionsDisorders1 Contamination and Decontamination
Tolin D, Meunier S. 1 Contamination and Decontamination. 2007, 3-18. DOI: 10.1016/b978-008044701-8/50002-4.Peer-Reviewed Original ResearchContamination-related obsessive-compulsive disorderObsessive-compulsive disorderContamination-related OCD symptomsForms of OCDMost treatment outcome studiesExposure-based treatmentsRole of disgustTreatment outcome studiesContamination fearSpecific fearsOCD symptomsMagic beliefsHabituation responseDisgustFearVague senseBeliefsDistressCompulsionStrong responseTreatment responsePatientsIndividualsDisordersRevulsion
2005
Stepped care for obsessive-compulsive disorder: A pilot study
Tolin D, Diefenbach G, Maltby N, Hannan S. Stepped care for obsessive-compulsive disorder: A pilot study. Cognitive And Behavioral Practice 2005, 12: 403-414. DOI: 10.1016/s1077-7229(05)80068-9.Peer-Reviewed Original ResearchObsessive-compulsive disorderFirst-line psychosocial treatmentPilot studyOCD patientsPercent of patientsClinical decision-making processIntensive treatment optionsEX/RPEX/RP treatmentCost-effectiveness analysisCognitive behavioral therapyResponder criteriaCare protocolsLow-intensity treatmentTreatment optionsPatient responseTreat samplePsychosocial treatmentsPatientsSymptom reductionBrief educationRitual preventionCostly treatmentExposure exercisesTreatment completers