2024
Central and peripheral physiological responses to decision making in hoarding disorder
Levy H, Naples A, Collett S, McPartland J, Tolin D. Central and peripheral physiological responses to decision making in hoarding disorder. International Journal Of Psychophysiology 2024, 205: 112437. PMID: 39265723, PMCID: PMC11502253, DOI: 10.1016/j.ijpsycho.2024.112437.Peer-Reviewed Original ResearchError-related negativityHoarding disorderControl participantsAlpha asymmetryPsychophysiological responsesIncreased frontal negativityGo/No-Go taskHealthy control participantsDecision-making taskPeripheral nervous system activityResponse to decisionsAnxiety disordersFrontal negativityNeurobiological modelsGo taskNeutral taskPsychiatric diagnosisExcessive clutterPsychophysiological measuresPersonal possessionsExaggerated activationDisordersNull resultsNervous system activityTask
2022
Central and peripheral nervous system responses to chronic and paced hyperventilation in anxious and healthy subjects
Tolin D, O'Bryan E, Davies C, Diefenbach G, Johannesen J. Central and peripheral nervous system responses to chronic and paced hyperventilation in anxious and healthy subjects. Biological Psychology 2022, 176: 108472. PMID: 36481266, PMCID: PMC9839632, DOI: 10.1016/j.biopsycho.2022.108472.Peer-Reviewed Original ResearchConceptsAnxious patientsCentral nervous system correlatesPeripheral nervous system responsesAlpha-1 powerPeripheral nervous systemFurther treatment developmentNervous system responsesHealthy control participantsHypocapnic patientsNormocapnic patientsChronic hyperventilationRespiratory distressEEG abnormalitiesHealthy subjectsSkin conductance levelNervous systemPatientsControl groupHealthy participantsPoor toleranceTreatment developmentSkin conductance response amplitudeControl participantsBreathing taskMechanistic target
2021
Psychophysiological assessment of stress reactivity and recovery in anxiety disorders
Tolin DF, Lee E, Levy HC, Das A, Mammo L, Katz BW, Diefenbach GJ. Psychophysiological assessment of stress reactivity and recovery in anxiety disorders. Journal Of Anxiety Disorders 2021, 82: 102426. PMID: 34022509, DOI: 10.1016/j.janxdis.2021.102426.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderCognitive behavioral therapyAnxiety disordersPanic disorderStressor phaseCBT outcomeHigh-frequency heart rate variabilityFrequency heart rate variabilityPsychophysiological reactivityEnd-tidal CODSM-5 anxiety disordersSpecialty outpatient clinicsHealthy control participantsHeart rate variabilityAdult patientsOutpatient clinicRate recoveryPatientsReactivity phaseResting phaseAnxious patientsAutonomic recoveryRate variabilityControl participantsDiminished changes
2012
Neural mechanisms of cognitive behavioral therapy response in Hoarding Disorder: A pilot study
Tolin D, Stevens M, Nave A, Villavicencio A, Morrison S. Neural mechanisms of cognitive behavioral therapy response in Hoarding Disorder: A pilot study. Journal Of Obsessive-Compulsive And Related Disorders 2012, 1: 180-188. DOI: 10.1016/j.jocrd.2012.04.001.Peer-Reviewed Original ResearchCognitive behavioral therapyMedial frontal gyrusFrontal gyrusHemodynamic activityManualized group cognitive behavioral therapyCognitive behavioral therapy responsePosterior cingulateFunctional magnetic resonance imaging (fMRI) taskGroup cognitive behavioral therapyRight superior temporal gyrusDecision-making taskInsula/putamenRight posterior hippocampusSuperior temporal gyrusHealthy control participantsParietal lobe regionsHippocampus/parahippocampusNeural functionHoarding DisorderNeural mechanismsBehavioral therapyTemporal gyrusPosterior hippocampusHC participantsLobe regions