1991
Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure
Silverstone D, Zimmerman T, Choplin N, Mundorf T, Rose A, Stoecker J, Kelley E, Lue J. Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure. American Journal Of Ophthalmology 1991, 112: 56-60. PMID: 1882923, DOI: 10.1016/s0002-9394(14)76213-0.Peer-Reviewed Original ResearchConceptsOpen-angle glaucomaLevobunolol groupTimolol groupOcular hypertensionIntraocular pressureThree-month study periodIncreased Intraocular PressureOcular hypotensive efficacyOverall mean decreaseMean heart rateHypotensive efficacyBlood pressureClinical trialsHeart rateMean decreaseTreatment groupsThree monthsPatientsStudy periodHypertensionGlaucomaGroupLevobunololTimololTherapy
1989
Effect of varying drop size on the efficacy and safety of a topical beta blocker.
Charap A, Shin D, Petursson G, Cinotti D, Wortham E, Brown R, Silverstone D, Atkins J, Eto C, Lue J. Effect of varying drop size on the efficacy and safety of a topical beta blocker. Annals Of Ophthalmology - Glaucoma 1989, 21: 351-7. PMID: 2683937.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAdultBlood PressureDosage FormsDose-Response Relationship, DrugDouble-Blind MethodElectrocardiographyExercise TestFollow-Up StudiesGlaucoma, Open-AngleHeart RateHumansIntraocular PressureLevobunololMiddle AgedMulticenter Studies as TopicRandom AllocationTime FactorsVisual AcuityConceptsIntraocular pressureBeta blockersHeart rateMicroL of vehicleTopical beta blockersMean intraocular pressureElevated intraocular pressureMean heart rateLevobunolol 0.5Levobunolol groupBlood pressureAcute studyTopical solutionVehicle groupChronic studiesMean decreaseControl groupOne hourEfficacyLevobunololBlockersSafetyGroupMicroLPatients
1988
Prophylactic Treatment of intraocular Pressure Elevations after Neodymium:YAG Laser Posterior Capsulotomies and Extracapsular Cataract Extractions with Levobunolol
Silverstone D, Novack G, Kelley E, Chen K. Prophylactic Treatment of intraocular Pressure Elevations after Neodymium:YAG Laser Posterior Capsulotomies and Extracapsular Cataract Extractions with Levobunolol. Ophthalmology 1988, 95: 713-718. PMID: 3062528, DOI: 10.1016/s0161-6420(88)33124-6.Peer-Reviewed Original ResearchConceptsYAG laser posterior capsulotomyExtracapsular cataract extractionLaser posterior capsulotomyIntraocular pressure elevationLevobunolol groupPosterior capsulotomyVehicle groupMean IOPPressure elevationProphylactic treatmentCataract extractionPosterior chamber intraocular lensVehicle 1 hourPlacebo-controlled studyUnilateral NDElevated IOPIOP elevationProphylactic effectIntraocular lensLevobunololCapsulotomyMmHgIOPPatientsElevation
1985
Levobunolol A Beta-adrenoceptor Antagonist Effective in the Long-term Treatment of Glaucoma
Group T, Berson F, Epstein D, Partamian L, Cinotti A, Cohen H, Fries P, David R, Gurion B, Duzman E, Novack G, Lue J, Foerster R, Galin M, Lass J, Ober M, Scharrer A, Shin D, Silverstone D. Levobunolol A Beta-adrenoceptor Antagonist Effective in the Long-term Treatment of Glaucoma. Ophthalmology 1985, 92: 1271-1276. PMID: 2865710, DOI: 10.1016/s0161-6420(85)33887-3.Peer-Reviewed Original ResearchConceptsLong-term treatmentDouble-masked studyOcular hypotensive efficacyOcular hypotensive effectOpen-angle glaucomaMean heart rateConcentrations of levobunololTest medicationOcular hypertensionBlood pressureMean IOPSystemic reactionsOcular safetyEffective therapyHeart rateOphthalmic solutionGlaucomaLevobunololPatientsTwo-year periodTimololTreatmentHypertensionMedicationsIOPLevobunolol vs Timolol for Open-Angle Glaucoma and Ocular Hypertension
Galin M, Cinotti A, Cinotti D, Grant W, Jacobs I, Silverstone D, Shin D, Esters J, Lee J, Bouchey R, Novack G, Duzman E, Lue J. Levobunolol vs Timolol for Open-Angle Glaucoma and Ocular Hypertension. American Journal Of Ophthalmology 1985, 99: 11-17. PMID: 3881032, DOI: 10.1016/s0002-9394(14)75859-3.Peer-Reviewed Original ResearchConceptsOpen-angle glaucomaIntraocular pressureOcular hypertensionMean reductionChronic open-angle glaucomaPercent of patientsTopical ophthalmic solutionOverall mean reductionLife-table estimatesSuccessful treatmentLevobunololOphthalmic solutionPatientsTimololHypertensionSignificant differencesGlaucomaHgMonths