Imatinib Resistance and Progression of CML to Blast Crisis: Somatic Hypermutation AIDing the Way
Strout MP, Schatz DG. Imatinib Resistance and Progression of CML to Blast Crisis: Somatic Hypermutation AIDing the Way. Cancer Cell 2009, 16: 174-176. PMID: 19732715, DOI: 10.1016/j.ccr.2009.08.012.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBenzamidesBlast CrisisCell Line, TumorCytidine DeaminaseDisease ProgressionDrug Resistance, NeoplasmHumansImatinib MesylateLeukemia, Myelogenous, Chronic, BCR-ABL PositiveModels, BiologicalMutationPiperazinesPyrimidinesConceptsChronic myeloid leukemiaProgression of CMLColleagues present evidenceDisease progressionImatinib resistanceMyeloid leukemiaDrug resistanceCancer cellsOncogenic mutationsProgressionEnzyme activation-induced deaminaseGeneration of mutationsLeukemiaMutationsActivation-induced deaminasePresent evidence