2024
The Role of RAG in V(D)J Recombination
Xiao J, Martin E, Wang K, Schatz D. The Role of RAG in V(D)J Recombination. 2024 DOI: 10.1016/b978-0-128-24465-4.00019-3.Peer-Reviewed Original ResearchRecombination signal sequencesRecombination activating geneV(D)J recombinationDNA cleavageConserved sequence elementsNonhomologous end-joining pathwayLymphoid-specific proteinsAntigen receptor gene segmentsEnd-joining pathwayPair of hairpinsReceptor gene segmentsTransposable elementsDomain architectureSequence elementsLocus structureSignal sequenceTransposition mechanismTranscriptional regulationJawed vertebratesTransposase activityActive genesPosttranslational modificationsEnhancer elementsProtein structureCell cycle
2020
Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin
Martin EC, Vicari C, Tsakou-Ngouafo L, Pontarotti P, Petrescu AJ, Schatz DG. Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin. Mobile DNA 2020, 11: 17. PMID: 32399063, PMCID: PMC7204232, DOI: 10.1186/s13100-020-00214-y.Peer-Reviewed Original ResearchProtostome genomesAdjacent gene pairsProtostome lineageBilaterian evolutionBilaterian ancestorJawed vertebratesProtostome evolutionBilateria cladeEarly deuterostomesEvolutionary historyBilaterian originGene pairsPhylogenetic analysisMultiple duplicationsRAG2 geneProtostomesEvolutionary precursorTransposase activityEarly bilateriansRibbon wormsIntact elementsGenomeDeuterostomesTransposonJ recombination