2019
TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer
Lio C, Shukla V, Samaniego-Castruita D, Avalos E, Chakraborty A, Yue X, Schatz D, Rao A. TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer. The Journal Of Immunology 2019, 202: 123.15-123.15. DOI: 10.4049/jimmunol.202.supp.123.15.Peer-Reviewed Original ResearchClass switch recombinationChromatin accessibilityTranscription factorsBasic region-leucine zipper (bZIP) transcription factorsBZIP transcription factorsZipper transcription factorAID expressionCytidine deaminase AIDExpression of AicdaTet-responsive elementEpigenetic marksTET enzymesEnhancer dynamicsAicda locusDNA demethylationGenomic regionsAicda expressionMurine B cellsEnhancer activitySwitch recombinationB cellsSuperenhancersTetExpressionCell activation
2015
Genomic landscape of cutaneous T cell lymphoma
Choi J, Goh G, Walradt T, Hong BS, Bunick CG, Chen K, Bjornson RD, Maman Y, Wang T, Tordoff J, Carlson K, Overton JD, Liu KJ, Lewis JM, Devine L, Barbarotta L, Foss FM, Subtil A, Vonderheid EC, Edelson RL, Schatz DG, Boggon TJ, Girardi M, Lifton RP. Genomic landscape of cutaneous T cell lymphoma. Nature Genetics 2015, 47: 1011-1019. PMID: 26192916, PMCID: PMC4552614, DOI: 10.1038/ng.3356.Peer-Reviewed Original Research
2005
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination
Rush JS, Liu M, Odegard VH, Unniraman S, Schatz DG. Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13242-13247. PMID: 16141332, PMCID: PMC1201576, DOI: 10.1073/pnas.0502779102.Peer-Reviewed Original ResearchConceptsClass switch recombinationCell divisionAID expressionSwitch recombinationFrequency of CSRSingle cell divisionSubsequent cell divisionSuccessive cell divisionsActivation-induced cytidine deaminaseConstitutive AID expressionIg heavy chain constant regionsEffector function propertiesHeavy chain constant regionActivation-induced cytidine deaminase mRNAMolecular explanationMechanistic basisDifferent molecular featuresSuccessive divisionsChain constant regionCytidine deaminaseB cell activationCytokine exposureExpressionConstant regionCell activation