2009
Racial and Sex Disparities in Life Expectancy Losses among HIV-Infected Persons in the United States: Impact of Risk Behavior, Late Initiation, and Early Discontinuation of Antiretroviral Therapy
Losina E, Schackman BR, Sadownik SN, Gebo KA, Walensky RP, Chiosi JJ, Weinstein MC, Hicks PL, Aaronson WH, Moore RD, Paltiel AD, Freedberg KA. Racial and Sex Disparities in Life Expectancy Losses among HIV-Infected Persons in the United States: Impact of Risk Behavior, Late Initiation, and Early Discontinuation of Antiretroviral Therapy. Clinical Infectious Diseases 2009, 49: 1570-1578. PMID: 19845472, PMCID: PMC2783631, DOI: 10.1086/644772.Peer-Reviewed Original ResearchConceptsEarly discontinuationHIV infectionAntiretroviral therapyYears of lifeLate initiationRisk behaviorsLate presentationHuman immunodeficiency virus (HIV) infectionHIV Research NetworkLate treatment initiationCohort of HIVImmunodeficiency virus infectionLife expectancyStandardized mortality ratioGeneral US populationHigh-risk profileYears of ageHigh-risk behaviorsSimilar demographic characteristicsRace/ethnicityART discontinuationART initiationCare concordantHispanic HIVAdvanced disease
2007
The Effect of Antiretroviral Therapy on Secondary Transmission of HIV among Men Who Have Sex with Men
McCormick AW, Walensky RP, Lipsitch M, Losina E, Hsu H, Weinstein MC, Paltiel AD, Freedberg KA, Seage GR. The Effect of Antiretroviral Therapy on Secondary Transmission of HIV among Men Who Have Sex with Men. Clinical Infectious Diseases 2007, 44: 1115-1122. PMID: 17366461, PMCID: PMC2365722, DOI: 10.1086/512816.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyCohort of individualsHuman immunodeficiency virus RNA loadEffect of ARTImpact of ARTFurther HIV transmissionUnprotected insertive anal intercourseHIV RNA levelsVirus RNA loadCohort of menSecondary transmissionYears of infectionInsertive anal intercourseRisk reduction interventionsHIV diseaseHIV infectionUntreated cohortHIV transmissionRNA loadVirologic courseSecondary casesAnal intercourseSecondary infectionHIVEffective HIV