Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra
Kamp F, Cabal G, Mairani A, Parodi K, Wilkens JJ, Carlson DJ. Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 557-568. PMID: 26460998, DOI: 10.1016/j.ijrobp.2015.07.2264.Peer-Reviewed Original ResearchConceptsRelative biological effectivenessCarbon ion therapyCarbon ionsIon therapyHeavy ion treatment planningMonte Carlo code FLUKAPrimary carbon ionsCarbon ion energyRadiation therapy beamsRBE valuesCarbon ion treatment plansRelevant RBE valuesRMF predictionsHeavy ionsIon energyDouble-strand break (DSB) yieldsRMF modelEnergy spectrumTherapy beamsSecondary fragmentsMonte Carlo damage simulationNuclear fragmentsBiological optimizationBiological effectivenessRBE predictionsHigh-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients
Shuryak I, Carlson DJ, Brown JM, Brenner DJ. High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients. Radiotherapy And Oncology 2015, 115: 327-334. PMID: 26058991, DOI: 10.1016/j.radonc.2015.05.013.Peer-Reviewed Original ResearchConceptsMulti-fraction stereotactic radiotherapyStereotactic radiotherapyTumoricidal mechanismsTumor controlHigh dosesSingle-dose stereotactic radiotherapySingle-fraction treatmentStereotactic radiation therapyTumor control dataBrain metastasesLung tumorsSRT patientsRadiation therapyTreatment dosesLow dosesSRT treatmentDosesLinear-quadratic modelPatientsFraction numberTreatmentLung dataLQ modelControl dataMetastasis