2016
The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery.
Kann BH, Yu JB, Stahl JM, Bond JE, Loiselle C, Chiang VL, Bindra RS, Gerrard JL, Carlson DJ. The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery. Journal Of Neurosurgery 2016, 125: 154-159. PMID: 27903196, DOI: 10.3171/2016.6.gks161497.Peer-Reviewed Original ResearchMeSH KeywordsCobalt RadioisotopesHumansRadiosurgeryRadiotherapy DosageRelative Biological EffectivenessConceptsTrigeminal neuralgiaGKRS treatmentObsessive-compulsive disorderTN managementEffective doseRefractory obsessive-compulsive disorderGamma Knife radiosurgery proceduresStudy of patientsGamma knife radiosurgeryRates of toxicitySingle-fraction dosesStudy of outcomesNerve ablationSerious sequelaePrescription dosesKnife radiosurgeryPrescription doseClinical studiesConclusion UseGKRSDose prescriptionGy/minRepair halftimeTreatment timeAuthors' departmentReal-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization
Song C, Hong BJ, Bok S, Lee CJ, Kim YE, Jeon SR, Wu HG, Lee YS, Cheon GJ, Paeng JC, Carlson DJ, Kim HJ, Ahn GO. Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization. International Journal Of Radiation Oncology • Biology • Physics 2016, 95: 1022-1031. PMID: 27130790, DOI: 10.1016/j.ijrobp.2016.01.064.Peer-Reviewed Original ResearchConceptsStereotactic ablative radiation therapyTumor/brain ratiosAblative radiation therapyRadiation therapyDay 0Day 6Brain ratioSingle doseVascular collapseHigh-dose irradiationDay 2Single high-dose irradiationHigh-dose radiation therapyTumor hypoxiaSyngeneic Lewis lung carcinomaHoechst 33342 perfusionTumor oxygenation changesRadiation therapy schedulesLewis lung carcinomaOrthotopic lung tumorsOptimal fractionation schedulePositron emission tomography (PET) imagingEmission Tomography ImagingTumor hypoxia levelsFluorescence-activated cell
2014
The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?
Brown JM, Carlson DJ, Brenner DJ. The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved? International Journal Of Radiation Oncology • Biology • Physics 2014, 88: 254-262. PMID: 24411596, PMCID: PMC3893711, DOI: 10.1016/j.ijrobp.2013.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsCell CycleCell HypoxiaCell ProliferationCell SurvivalDNA DamageDNA RepairDose Fractionation, RadiationEndothelial CellsHumansLinear ModelsMelanomaMiceModels, BiologicalNeoplasmsOxygen ConsumptionRadiation ToleranceRadiobiologyRadiosurgeryRelative Biological Effectiveness
2013
Dose Escalation, Not “New Biology,” Can Account for the Efficacy of Stereotactic Body Radiation Therapy With Non-Small Cell Lung Cancer
Brown JM, Brenner DJ, Carlson DJ. Dose Escalation, Not “New Biology,” Can Account for the Efficacy of Stereotactic Body Radiation Therapy With Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2013, 85: 1159-1160. PMID: 23517805, PMCID: PMC3608927, DOI: 10.1016/j.ijrobp.2012.11.003.Peer-Reviewed Original Research