1995
Tropical spastic paraparesis on the Caribbean coast of Colombia.
Dangond F, Daza JS, Rosania A, Quin MJ, Zaninovic V, Chaplin B, Marlink R, Hafler DA. Tropical spastic paraparesis on the Caribbean coast of Colombia. American Journal Of Tropical Medicine And Hygiene 1995, 52: 155-8. PMID: 7872443, DOI: 10.4269/ajtmh.1995.52.155.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesColombiaFemaleHTLV-I AntibodiesHumansMaleNeurologic ExaminationParaparesis, Tropical SpasticConceptsTropical spastic paraparesisSpastic paraparesisHuman T-cell lymphotropic virus type 1Chronic spastic paraparesisProgressive leg weaknessVirus type 1Enzyme-linked immunosorbent assayChronic myelopathySerum positivityLeg weaknessRetroviral diseaseParaparesisType 1Western blotImmunosorbent assayPatientsEthnic originFirst reportMyelopathyDiseaseAntibodies
1993
Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group.
Weiner HL, Mackin GA, Orav EJ, Hafler DA, Dawson DM, LaPierre Y, Herndon R, Lehrich JR, Hauser SL, Turel A, Fisher M, Birnbaum G, McArthur J, Butler R, Moore M, Sigsbee B, Safran A. Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology 1993, 43: 910-8. PMID: 8388090, DOI: 10.1212/wnl.43.5.910.Peer-Reviewed Original ResearchConceptsMajority of patientsInduction regimenTreatment failureTreatment groupsCyclophosphamide pulse therapyPatients 40 yearsPatients ages 41Progressive MS patientsPulse cyclophosphamide therapyPatients age 18Progressive multiple sclerosisNonbooster groupPulse therapyCyclophosphamide therapyProgressive MSMS patientsMultiple sclerosisDisease progressionSignificant benefitsAge 41Subsequent progressionPatientsInitial stabilizationAge 18Regimen