1993
Biological activity of recombinant human myelin basic protein
Oettinger H, Al-Sabbagh A, Jingwu Z, LaSalle J, Weiner H, Hafler D. Biological activity of recombinant human myelin basic protein. Journal Of Neuroimmunology 1993, 44: 157-162. PMID: 7685037, DOI: 10.1016/0165-5728(93)90037-y.Peer-Reviewed Original ResearchConceptsRecombinant human myelin basic proteinRecombinant protein bindsRecombinant MBPInducible expression vectorBasic proteinMyelin basic proteinRecombinant protein preparationsProtein bindsHuman myelin basic proteinRecombinant proteinsExpression vectorEscherichia coliProtein preparationsProteinNative MBPE. coliCation exchange chromatographySDS-PAGEBiological reagentsSimilar affinityHuman MBPColiBiological activitySimilar conformationsCell clones
1990
Shared Human T Cell Receptor Vβ Usage to Immunodominant Regions of Myelin Basic Protein
Wucherpfennig K, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner H, Hafler D. Shared Human T Cell Receptor Vβ Usage to Immunodominant Regions of Myelin Basic Protein. Science 1990, 248: 1016-1019. PMID: 1693015, DOI: 10.1126/science.1693015.Peer-Reviewed Original ResearchConceptsMultiple sclerosisImmunodominant regionMyelin basic proteinMS patientsT cellsBeta 17T cell receptor Vβ usageTCR V beta gene usageReactive T cellsBeta gene usageT cell receptor beta chainT cell linesBasic proteinSpecific immunotherapyVβ usageAutoimmune diseasesReceptor beta chainHealthy subjectsTarget antigenGene usageBeta 12Myelin proteinsTCR structureHuman MBPBeta chain