Early signaling defects in human T cells anergized by T cell presentation of autoantigen.
LaSalle JM, Tolentino PJ, Freeman GJ, Nadler LM, Hafler DA. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. Journal Of Experimental Medicine 1992, 176: 177-186. PMID: 1535366, PMCID: PMC2119294, DOI: 10.1084/jem.176.1.177.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsT cell presentationPhorbol myristate acetateT cellsAnergized T cellsCell presentationL cell transfectantsProliferative responseAlpha CD3B cellsMajor histocompatibility complex classHuman T cell clonesPrimary proliferative responsesAllogeneic B cellsT cell anergyT cell clonesHistocompatibility complex classInduction of anergyInterferon-gamma mRNANormal proliferative responseT cell activationCD2 monoclonal antibodiesT cell receptorCell transfectantsPresence of costimulation