2024
Incremental hemodialysis transition in veterans and nonveterans with kidney failure
Rhee C, Kovesdy C, Unruh M, Crowley S, Geller D, Goldfarb D, Kraut J, Rastegar M, Rifkin I, Kalantar-Zadeh K. Incremental hemodialysis transition in veterans and nonveterans with kidney failure. Current Opinion In Nephrology & Hypertension 2024, 34: 33-40. PMID: 39611277, DOI: 10.1097/mnh.0000000000001040.Peer-Reviewed Original ResearchConceptsHealth-related quality of lifeEnd-stage kidney diseaseResidual kidney functionAssociated with impaired health-related quality of lifeImpaired health-related quality of lifeTwice-weekly hemodialysisLow patient burdenHigher mortality riskQuality of lifeRandomized controlled trialsTransition to dialysisReceive careResidual kidney function preservationIncremental hemodialysisInitiation of hemodialysis treatmentMortality riskPatient burdenESKD populationPragmatic studyYear of treatmentVeteransStandard of careThrice-weekly hemodialysisDialysis transitionCare
2001
A mineralocorticoid receptor mutation causing human hypertension
Geller D. A mineralocorticoid receptor mutation causing human hypertension. Current Opinion In Nephrology & Hypertension 2001, 10: 661-665. PMID: 11496062, DOI: 10.1097/00041552-200109000-00018.Commentaries, Editorials and LettersConceptsBlood pressureHuman hypertensionMineralocorticoid receptor mutationsMineralocorticoid receptorSevere worseningDistal nephronHypertensionReceptor mutationsCardiovascular physiologyMonogenic formsSodium transportReceptor biologyFunction mutationsMutationsNotable findingPregnancyRegulatory mechanismsWorseningFindingsNephronReceptorsMolecular Mechanisms of Human Hypertension
Lifton R, Gharavi A, Geller D. Molecular Mechanisms of Human Hypertension. Cell 2001, 104: 545-556. PMID: 11239411, DOI: 10.1016/s0092-8674(01)00241-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2000
Activating Mineralocorticoid Receptor Mutation in Hypertension Exacerbated by Pregnancy
Geller D, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai F, Sigler P, Lifton R. Activating Mineralocorticoid Receptor Mutation in Hypertension Exacerbated by Pregnancy. Science 2000, 289: 119-123. PMID: 10884226, DOI: 10.1126/science.289.5476.119.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAldosteroneAmino Acid SequenceAmino Acid SubstitutionBase SequenceBinding, CompetitiveDimerizationFemaleHeterozygoteHumansHypertensionMaleModels, MolecularMolecular Sequence DataPedigreePoint MutationPregnancyPregnancy Complications, CardiovascularProgesteroneProtein ConformationProtein Structure, SecondaryReceptors, MineralocorticoidReceptors, SteroidSteroidsConceptsMineralocorticoid receptorMajor public health problemMineralocorticoid receptor mutationsPregnancy-related hypertensionEarly-onset hypertensionPublic health problemMR antagonistsUnknown causeHypertensionReceptor mutationsHealth problemsNuclear hormone receptorsReceptor activationPotent agonistHormone receptorsReceptor specificityMR activityWild-type receptorReceptorsPregnancyMutationsBiochemical studiesGroupProgesteroneAgonists
1998
Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I
Geller D, Rodriguez-Soriano J, Boado A, Schifter S, Bayer M, Chang S, Lifton R. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nature Genetics 1998, 19: 279-281. PMID: 9662404, DOI: 10.1038/966.Peer-Reviewed Original ResearchConceptsMineralocorticoid receptor genePseudohypoaldosteronism type IMineralocorticoid receptor functionBlood pressure homeostasisElevated aldosterone levelsSteroid hormone aldosteroneBlood pressure variationReceptor geneType IAldosterone levelsEpithelial sodium channelMild diseaseMetabolic acidosisPressure homeostasisRenal saltHormone aldosteroneSevere diseaseRegulation of saltAmiloride-sensitive epithelial sodium channelAutosomal recessive formReceptor functionHeterozygous mutationsSodium channelsUnaffected subjectsGene mutations