2020
Chapter 22: Structural and signaling functions of integrins
Kadry YA, Calderwood DA. Chapter 22: Structural and signaling functions of integrins. Biochimica Et Biophysica Acta (BBA) - Biomembranes 2020, 1862: 183206. PMID: 31991120, PMCID: PMC7063833, DOI: 10.1016/j.bbamem.2020.183206.Peer-Reviewed Original ResearchConceptsFunction of integrinsAbility of integrinsTransmembrane adhesion receptorsNon-redundant functionsDifferent integrin heterodimersExtracellular matrix proteinsComplex structural rearrangementsDiverse downstreamCytoskeletal complexMetazoan lifeExtracellular environmentΒ-subunitAdhesion receptorsIntegrin heterodimersIntegrin familyMatrix proteinsCell adhesionIntegrinsStructural rearrangementsHeterodimersRecent advancesSubunitsSignalingProteinFunction
2012
Zasp regulates integrin activation
Bouaouina M, Jani K, Long JY, Czerniecki S, Morse EM, Ellis SJ, Tanentzapf G, Schöck F, Calderwood DA. Zasp regulates integrin activation. Journal Of Cell Science 2012, 125: 5647-5657. PMID: 22992465, PMCID: PMC3575701, DOI: 10.1242/jcs.103291.Peer-Reviewed Original ResearchConceptsIntegrin activationDomain-containing proteinsExtracellular matrixHeterodimeric adhesion receptorsPDZ motif-containing proteinΑ5β1 integrinMammalian tissue cultureScaffold proteinCytoplasmic tailFirst proteinECM ligandsMuscle contractile machineryΒ-integrinExtracellular domainAdhesion receptorsIntegrin heterodimersTalinConformational changesHigh-affinity bindingEssential processProteinIntegrinsHuman cardiomyopathyZASPTissue culture