2022
Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding
Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsGastrointestinal bleedingPrimary preventionCardiovascular eventsRisk of MACEYale-New Haven HospitalPrimary cardiovascular preventionAdverse cardiovascular eventsKaplan-Meier curvesLong-term outcomesRisk-benefit ratioLog-rank testAspirin 81Hospitalised patientsPrimary endpointSecondary endpointsCardiovascular preventionSubsequent hospitalisationMedian ageDeprescriptionHigh riskAspirinHospitalisationPatientsPreventionEndoscopic Management of Esophageal Cancer.
Dobashi A, Li DK, Mavrogenis G, Visrodia KH, Bazerbachi F. Endoscopic Management of Esophageal Cancer. Thoracic Surgery Clinics 2022, 32: 479-495. PMID: 36266035, DOI: 10.1016/j.thorsurg.2022.07.005.Peer-Reviewed Original ResearchInhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury.
Li DK, Chaudhari SN, Lee Y, Sojoodi M, Adhikari AA, Zukerberg L, Shroff S, Barrett SC, Tanabe K, Chung RT, Devlin AS. Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury. Science Advances 2022, 8: eabo2794. PMID: 36026454, PMCID: PMC9417178, DOI: 10.1126/sciadv.abo2794.Peer-Reviewed Original ResearchLow-Volume Bowel Preparation Is Associated With Reduced Time to Colonoscopy in Hospitalized Patients: A Propensity-Matched Analysis.
Sun CLF, Li DK, Zenteno AC, Bravard MA, Carolan P, Daily B, Elamin S, Ha J, Moore A, Safavi K, Yun BJ, Dunn P, Levi R, Richter JM. Low-Volume Bowel Preparation Is Associated With Reduced Time to Colonoscopy in Hospitalized Patients: A Propensity-Matched Analysis. Clinical And Translational Gastroenterology 2022, 13: e00482. PMID: 35347098, DOI: 10.14309/ctg.0000000000000482.Peer-Reviewed Original ResearchMicroangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study
Lam R, Tarangelo N, Wang R, Horibe M, Grimshaw AA, Jain D, Haffar S, Bazerbachi F, Kunz PL, Li DK. Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study. The Oncologist 2022, 27: 751-759. PMID: 35589098, PMCID: PMC9438916, DOI: 10.1093/oncolo/oyac093.Peer-Reviewed Original ResearchConceptsGastric signet ring cell carcinomaSignet ring cell carcinomaMicroangiopathic hemolytic anemiaHemolytic anemiaCell carcinomaMultivariable Cox proportional hazards regression modelingCox proportional hazards regression modelingSystematic reviewRare paraneoplastic syndromeStage-matched casesEnd Results (SEER) databaseLate-stage complicationsRisk of mortalityCase-control studyBone painParaneoplastic syndromeFatal complicationMedian survivalMetastatic diseaseOverall survivalLymph nodesIndex presentationPrognostic featuresResults databasePooled cohort
2021
Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists
Hughes ML, Li DK, Hung KW, Laine L. Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists. The American Journal Of Gastroenterology 2021, 117: 361-363. PMID: 34904965, DOI: 10.14309/ajg.0000000000001585.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLiver chemistries in glycogenic hepatopathy associated with type 1 diabetes mellitus: A systematic review and pooled analysis.
Haffar S, Izzy M, Habib H, Sugihara T, Li DK, Sharma A, Wang Z, Murad MH, Watt KD, Bazerbachi F. Liver chemistries in glycogenic hepatopathy associated with type 1 diabetes mellitus: A systematic review and pooled analysis. Liver International : Official Journal Of The International Association For The Study Of The Liver 2021, 41: 1545-1555. PMID: 33595181, DOI: 10.1111/liv.14827.Peer-Reviewed Original ResearchVerrucous esophageal carcinoma is a unique indolent subtype of squamous cell carcinoma: a systematic review and individual patient regression analysis.
Li DK, Haffar S, Horibe M, Homsi HA, Zukerberg L, Murad MH, Visrodia KH, Gala M, Katzka DA, Bazerbachi F. Verrucous esophageal carcinoma is a unique indolent subtype of squamous cell carcinoma: a systematic review and individual patient regression analysis. Journal Of Gastroenterology 2021, 56: 12-24. PMID: 33079233, DOI: 10.1007/s00535-020-01736-1.Peer-Reviewed Original Research
2020
Normal liver stiffness and influencing factors in healthy children: An individual participant data meta-analysis.
Li DK, Khan MR, Wang Z, Chongsrisawat V, Swangsak P, Teufel-Schäfer U, Engelmann G, Goldschmidt I, Baumann U, Tokuhara D, Cho Y, Rowland M, Mjelle AB, Ramm GA, Lewindon PJ, Witters P, Cassiman D, Ciuca IM, Prokop LD, Haffar S, Corey KE, Murad MH, Furuya KN, Bazerbachi F. Normal liver stiffness and influencing factors in healthy children: An individual participant data meta-analysis. Liver International : Official Journal Of The International Association For The Study Of The Liver 2020, 40: 2602-2611. PMID: 32901449, DOI: 10.1111/liv.14658.Peer-Reviewed Original Research
2019
Overview of Direct-Acting Antiviral Drugs and Drug Resistance of Hepatitis C Virus.
Li DK, Chung RT. Overview of Direct-Acting Antiviral Drugs and Drug Resistance of Hepatitis C Virus. Methods In Molecular Biology (Clifton, N.J.) 2019, 1911: 3-32. PMID: 30593615, DOI: 10.1007/978-1-4939-8976-8_1.Books
2018
The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study.
Li DK, Ren Y, Fierer DS, Rutledge S, Shaikh OS, Lo Re V, Simon T, Abou-Samra AB, Chung RT, Butt AA. The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study. Hepatology (Baltimore, Md.) 2018, 67: 2244-2253. PMID: 29205416, DOI: 10.1002/hep.29707.Peer-Reviewed Original ResearchProton pump inhibitors are associated with accelerated development of cirrhosis, hepatic decompensation and hepatocellular carcinoma in noncirrhotic patients with chronic hepatitis C infection: results from ERCHIVES.
Li DK, Yan P, Abou-Samra AB, Chung RT, Butt AA. Proton pump inhibitors are associated with accelerated development of cirrhosis, hepatic decompensation and hepatocellular carcinoma in noncirrhotic patients with chronic hepatitis C infection: results from ERCHIVES. Alimentary Pharmacology & Therapeutics 2018, 47: 246-258. PMID: 29105111, DOI: 10.1111/apt.14391.Peer-Reviewed Original Research
2017
Use of proton pump inhibitors in chronic liver diseases.
Li DK, Chung RT. Use of proton pump inhibitors in chronic liver diseases. Clinical Liver Disease 2017, 10: 148-151. PMID: 30992776, PMCID: PMC6467129, DOI: 10.1002/cld.678.Peer-Reviewed Original Research
2015
Impact of hepatitis C virus eradication on hepatocellular carcinogenesis.
Li DK, Chung RT. Impact of hepatitis C virus eradication on hepatocellular carcinogenesis. Cancer 2015, 121: 2874-82. PMID: 26079399, PMCID: PMC4545677, DOI: 10.1002/cncr.29528.Peer-Reviewed Original Research
2014
SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.
Li DK, Tisdale S, Lotti F, Pellizzoni L. SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease. Seminars In Cell & Developmental Biology 2014, 32: 22-9. PMID: 24769255, PMCID: PMC4110182, DOI: 10.1016/j.semcdb.2014.04.026.Peer-Reviewed Original Research
2013
A cell system for phenotypic screening of modifiers of SMN2 gene expression and function.
Li DK, Tisdale S, Espinoza-Derout J, Saieva L, Lotti F, Pellizzoni L. A cell system for phenotypic screening of modifiers of SMN2 gene expression and function. PloS One 2013, 8: e71965. PMID: 23967270, PMCID: PMC3744461, DOI: 10.1371/journal.pone.0071965.Peer-Reviewed Original Research
2012
An SMN-dependent U12 splicing event essential for motor circuit function.
Lotti F, Imlach WL, Saieva L, Beck ES, Hao le T, Li DK, Jiao W, Mentis GZ, Beattie CE, McCabe BD, Pellizzoni L. An SMN-dependent U12 splicing event essential for motor circuit function. Cell 2012, 151: 440-54. PMID: 23063131, PMCID: PMC3474596, DOI: 10.1016/j.cell.2012.09.012.Peer-Reviewed Original ResearchA role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy.
Ruggiu M, McGovern VL, Lotti F, Saieva L, Li DK, Kariya S, Monani UR, Burghes AH, Pellizzoni L. A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy. Molecular And Cellular Biology 2012, 32: 126-38. PMID: 22037760, PMCID: PMC3255708, DOI: 10.1128/MCB.06077-11.Peer-Reviewed Original Research
2006
Recognition in vitro of the suppressor tRNAPyl by the class II‐like Pyrrolsyl‐tRNA Synthetase
Herring S, Li D, Ambrogelly A, Polycarpo C, Soll D. Recognition in vitro of the suppressor tRNAPyl by the class II‐like Pyrrolsyl‐tRNA Synthetase. The FASEB Journal 2006, 20: a503-a503. DOI: 10.1096/fasebj.20.4.a503-b.Peer-Reviewed Original ResearchMischarging of M. barkeri tRNAPyl with alanine and serine in vitro
Li D, Polycarpo C, Ambrogelly A, Söll D. Mischarging of M. barkeri tRNAPyl with alanine and serine in vitro. The FASEB Journal 2006, 20: a503-a503. DOI: 10.1096/fasebj.20.4.a503-c.Peer-Reviewed Original ResearchNon-canonical amino acidsSecondary structureCognate tRNA speciesPyrrolysyl-tRNA synthetaseAminoacyl-tRNA synthetaseSimilar secondary structureBovine mitochondriaTRNA speciesAlanine tRNAAnticodon stemAcceptor stemAmino acidsM. barkeriMethanosarcina barkeriSerRSsPyrrolysineMultiple mutationsVariable loopSynthetaseSerineShorter variable loopsSynthetase systemBarkeriAlanineStem