2014
Comparison of a Closed System to a Standard Open Technique for Preparing Tissue-Engineered Vascular Grafts
Kurobe H, Maxfield MW, Naito Y, Cleary M, Stacy MR, Solomon D, Rocco KA, Tara S, Lee AY, Sinusas AJ, Snyder EL, Shinoka T, Breuer CK. Comparison of a Closed System to a Standard Open Technique for Preparing Tissue-Engineered Vascular Grafts. Tissue Engineering Part C Methods 2014, 21: 88-93. PMID: 24866863, PMCID: PMC4291206, DOI: 10.1089/ten.tec.2014.0160.Peer-Reviewed Original Research
2013
Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue-Engineered Vascular Grafts in the Venous Circulation Using a Murine Model
Naito Y, Lee YU, Yi T, Church SN, Solomon D, Humphrey JD, Shin'oka T, Breuer CK. Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue-Engineered Vascular Grafts in the Venous Circulation Using a Murine Model. Tissue Engineering Part A 2013, 20: 346-355. PMID: 23957852, PMCID: PMC3875183, DOI: 10.1089/ten.tea.2012.0613.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaBlood CirculationBlood Vessel ProsthesisExtracellular MatrixFibrillin-1FibrillinsImplants, ExperimentalMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, SCIDMicrofilament ProteinsModels, AnimalPressureTissue EngineeringTissue ScaffoldsVena Cava, InferiorConceptsTissue-engineered vascular graftsMechanical propertiesBiaxial propertiesNeotissue formationBiaxial mechanical propertiesWeeks of implantationVascular graftsBurst pressureBiodegradable scaffoldsVascular neotissue formationMicrostructural compositionMechanobiological principlesPropertiesGreat promiseBenchDeposition
2011
Vascular tissue engineering: Towards the next generation vascular grafts
Naito Y, Shinoka T, Duncan D, Hibino N, Solomon D, Cleary M, Rathore A, Fein C, Church S, Breuer C. Vascular tissue engineering: Towards the next generation vascular grafts. Advanced Drug Delivery Reviews 2011, 63: 312-323. PMID: 21421015, DOI: 10.1016/j.addr.2011.03.001.Peer-Reviewed Original ResearchConceptsBone marrow-derived mononuclear cellsClinical trialsAutologous bone marrow-derived mononuclear cellsNext-generation vascular graftsMarrow-derived mononuclear cellsVascular graftsExcellent safety profileFirst clinical trialRisk of infectionBiodegradable tubular scaffoldsTissue engineering technologyPrimary graftSafety profileMononuclear cellsCardiovascular diseaseTubular scaffoldsCardiovascular surgeryGraftSynthetic vascular graftsVascular neotissue formationNeotissue formationContinued investigationTEVGsEngineering technologyTrials