2020
COVID-19 guidance for triage of operations for thoracic malignancies: A consensus statement from Thoracic Surgery Outcomes Research Network
Network I, Antonoff M, Backhus L, Boffa DJ, Broderick SR, Brown LM, Carrott P, Clark JM, Cooke D, David E, Facktor M, Farjah F, Grogan E, Isbell J, Jones DR, Kidane B, Kim AW, Keshavjee S, Krantz S, Lui N, Martin L, Meguid RA, Meyerson SL, Mullett T, Nelson H, Odell DD, Phillips JD, Puri V, Rusch V, Shulman L, Varghese TK, Wakeam E, Wood DE. COVID-19 guidance for triage of operations for thoracic malignancies: A consensus statement from Thoracic Surgery Outcomes Research Network. Journal Of Thoracic And Cardiovascular Surgery 2020, 160: 601-605. PMID: 32689703, PMCID: PMC7146695, DOI: 10.1016/j.jtcvs.2020.03.061.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusClinical Decision-MakingConsensusCoronavirus InfectionsCOVID-19Delivery of Health Care, IntegratedHealth Services Needs and DemandHost Microbial InteractionsHumansNeeds AssessmentOccupational HealthPandemicsPatient SafetyPatient SelectionPneumonia, ViralRisk AssessmentRisk FactorsSARS-CoV-2Thoracic NeoplasmsThoracic Surgical ProceduresTime-to-TreatmentTriageSurgeon's Perspective to Local Therapy in Oligometastatic Cancer.
Boffa DJ. Surgeon's Perspective to Local Therapy in Oligometastatic Cancer. The Cancer Journal 2020, 26: 149-155. PMID: 32205540, DOI: 10.1097/ppo.0000000000000441.Peer-Reviewed Original Research
2019
Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma
Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2019, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedCohort StudiesDatabases, FactualDisease-Free SurvivalFemaleHumansImmunotherapyKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPneumonectomyPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisTumor MicroenvironmentConceptsTumor immune microenvironmentImmune microenvironmentLung adenocarcinomaOverall survivalRisk groupsMast cellsCox proportional hazard modelingEarly-stage lung adenocarcinomaLow-risk subtypesKaplan-Meier analysisPathological staging systemProportional hazard modelingImproved clinical outcomesCancer immune microenvironmentImmune cell typesEarly lung adenocarcinomaActivation stateClinical outcomesValidation cohortMacrophage contentStaging systemMultivariable modelCIBERSORT analysisPatientsClinical decision
2018
Lack of correlation between short- and long-term performance after lung cancer surgery
Fernandez FG, Kosinski AS, Tong BC, Furnary AP, Feng L, Onaitis M, Boffa D, Wright CD, Cowper P, Jacobs JP, Habib RH, Putnam JB. Lack of correlation between short- and long-term performance after lung cancer surgery. Journal Of Thoracic And Cardiovascular Surgery 2018, 157: 1633-1643.e3. PMID: 30635179, DOI: 10.1016/j.jtcvs.2018.09.141.Peer-Reviewed Original ResearchConceptsLung cancer surgeryStandardized incidence ratiosCancer surgeryLong-term survivalPerioperative morbidityIncidence ratiosPathologic stage I lung cancerStage I lung cancerThoracic Surgeons General Thoracic Surgery DatabaseI lung cancerPerioperative major morbidityGeneral Thoracic Surgery DatabaseLong-term time pointsSeparate multivariable modelsSafety of surgeryThoracic Surgery DatabaseMajor morbidityOncologic efficacyLung cancerSurgery DatabaseMultivariable modelStudy populationSurgeryMorbidityTime points
2017
Effectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians
Arnold BN, Thomas DC, Rosen JE, Salazar MC, Detterbeck FC, Blasberg JD, Boffa DJ, Kim AW. Effectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians. Surgery 2017, 162: 640-651. PMID: 28697883, DOI: 10.1016/j.surg.2017.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overCarcinoma, Non-Small-Cell LungConfidence IntervalsDatabases, FactualDisease-Free SurvivalFemaleGeriatric AssessmentHumansKaplan-Meier EstimateLogistic ModelsLung NeoplasmsMaleMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingOdds RatioPneumonectomyProportional Hazards ModelsRadiotherapyRegistriesRisk AssessmentSecondary PreventionSurvival AnalysisConceptsCell lung cancerLocal therapyLung cancerStage IRelative survivalStereotactic body radiation therapyNational Cancer DatabaseBetter overall survivalBody radiation therapyOlder patientsOverall survivalPatient ageYounger patientsOverall mortalityPrimary outcomeCancer DatabaseTreatment outcomesTreatment decisionsRadiation therapyPatientsTherapyCancerNonagenariansTreatmentSurvival