2024
Survival Among Patients With High-Risk Gastrointestinal Cancers During the COVID-19 Pandemic
Janczewski L, Browner A, Cotler J, Palis B, Chan K, Joung R, Bentrem D, Merkow R, Boffa D, Nelson H. Survival Among Patients With High-Risk Gastrointestinal Cancers During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e240160. PMID: 38441896, PMCID: PMC10915687, DOI: 10.1001/jamanetworkopen.2024.0160.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19Databases, FactualFemaleGastrointestinal NeoplasmsHumansMalePandemicsRetrospective StudiesConceptsStage IV diseaseRetrospective cohort studyCohort studyQuality care deliveryIV diseaseOperative mortalityHigh riskPandemic-related stressorsAssociated with increased 1-year mortalityDiagnosis of stage IMultivariate logistic regressionCOVID-19 pandemicCare deliveryNational Cancer DatabaseKaplan-Meier curvesEvaluate 30-dayMain OutcomesFollow-up dataCancer communityPrepandemic levelsLogistic regressionCancer DatabaseCOVID-19COVID-19 infectionMalignant neoplasms
2023
Alterations in Cancer Treatment During the First Year of the COVID-19 Pandemic in the US
Janczewski L, Cotler J, Merkow R, Palis B, Nelson H, Mullett T, Boffa D. Alterations in Cancer Treatment During the First Year of the COVID-19 Pandemic in the US. JAMA Network Open 2023, 6: e2340148. PMID: 37902756, PMCID: PMC10616721, DOI: 10.1001/jamanetworkopen.2023.40148.Peer-Reviewed Original ResearchMeSH KeywordsAgedCOVID-19Databases, FactualFemaleHospitals, CommunityHumansMaleMiddle AgedNeoplasmsPandemicsRetrospective StudiesConceptsNational Cancer DatabaseCancer treatmentAcademic hospitalCommunity hospitalMAIN OUTCOMECOVID-19 pandemicProportion of patientsRetrospective cohort studyAvailability of treatmentFirst yearUnderwent surgeryCohort studyMedian ageCancer surgeryMedian timeTreatment of cancerCancer careTreatment modalitiesCancer screeningCancer DatabaseMedian travel distancePatientsHospitalSurgeryCancer
2022
Evaluating information loss in the National Cancer Database from cases lost to follow‐up
Cotler JH, Nogueira L, McCabe R, Nelson H, Brajcich BC, Boffa DJ, Lum SS, Harris JB, Hawhee V, Mullett TW, Bilimoria KY, Palis BE. Evaluating information loss in the National Cancer Database from cases lost to follow‐up. Journal Of Surgical Oncology 2022, 126: 1123-1132. PMID: 36029288, DOI: 10.1002/jso.26977.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreast NeoplasmsChildDatabases, FactualFemaleHumansLost to Follow-UpRegistriesSurvival AnalysisSurvival RateConceptsNational Cancer DatabaseCancer casesPediatric casesAdult casesCancer DatabaseRectal cancer casesLung cancer casesMean survival timeBreast cancer casesHazard ratioCancer RegistryYears postdiagnosisSurvival outcomesLymphoma casesSurvival timeLeukemia casesSurvival analysisResource burdenFollowTotalMinimal differencesYearsAnnual increasePostdiagnosisPatients
2021
Twenty-Five Years of Cancer Follow-Up; Is the Data Worth the Effort?
Brajcich BC, Palis BE, McCabe R, Nogueira L, Boffa DJ, Lum SS, Harris JB, Hawhee V, Mullett TW, Bilimoria KY, Nelson H. Twenty-Five Years of Cancer Follow-Up; Is the Data Worth the Effort? Annals Of Surgical Oncology 2021, 29: 828-836. PMID: 34689251, DOI: 10.1245/s10434-021-10668-w.Peer-Reviewed Original Research
2020
Costs Associated With Lobectomy for Lung Cancer: An Analysis Merging STS and Medicare Data
Medbery RL, Fernandez FG, Kosinski AS, Tong BC, Furnary AP, Feng L, Onaitis M, Boffa D, Wright CD, Cowper P, Jacobs JP, Putnam JB, Habib RH. Costs Associated With Lobectomy for Lung Cancer: An Analysis Merging STS and Medicare Data. The Annals Of Thoracic Surgery 2020, 111: 1781-1790. PMID: 33188754, DOI: 10.1016/j.athoracsur.2020.08.073.Peer-Reviewed Original ResearchConceptsLung cancerHospital characteristicsMedicare dataClinical stage I lung cancerCare costsRecurrent laryngeal nerve paresisStage I lung cancerEarly-stage lung cancerThoracic Surgeons General Thoracic Surgery DatabaseI lung cancerPreoperative patient factorsChronic kidney diseaseGeneral Thoracic Surgery DatabaseLaryngeal nerve paresisSeverity of complicationsBody mass indexCase-mix factorsCare of patientsNumber of complicationsThoracic Surgery DatabaseNerve paresisPerioperative outcomesPostoperative complicationsRespiratory failureExpiratory volumeIntestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction
Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction. Human Pathology 2020, 105: 67-73. PMID: 32941964, PMCID: PMC11152084, DOI: 10.1016/j.humpath.2020.08.007.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsBile refluxIntestinal metaplasiaReactive gastropathyGEJ regionMucosal injuryMucosal changesGastroesophageal junctionAntral intestinal metaplasiaDistal esophageal adenocarcinomaDetailed clinical historySex-matched patientsGastric antral biopsiesAnti-inflammatory drugsGastric bile refluxMucosal inflammationProximal stomachDistal esophagusMedication usePancreatic metaplasiaPathology databaseProximal gastricAntral biopsiesClinical historyGastric biopsiesSurvival After Cancer Treatment at Top-Ranked US Cancer Hospitals vs Affiliates of Top-Ranked Cancer Hospitals
Boffa DJ, Mallin K, Herrin J, Resio B, Salazar MC, Palis B, Facktor M, McCabe R, Nelson H, Shulman LN. Survival After Cancer Treatment at Top-Ranked US Cancer Hospitals vs Affiliates of Top-Ranked Cancer Hospitals. JAMA Network Open 2020, 3: e203942. PMID: 32453382, PMCID: PMC7251445, DOI: 10.1001/jamanetworkopen.2020.3942.Peer-Reviewed Original ResearchConceptsLong-term survivalCancer HospitalSurgical treatmentShort-term survivalComplex cancer treatmentAffiliate hospitalsCancer treatmentCancer careAdjusted long-term survivalNational Cancer DatabaseAnnual surgical volumeComplex cancer careIndividuals 18 yearsComplex surgical proceduresPerioperative mortalityCohort studyAffiliated HospitalPooled analysisBladder cancerCancer DatabasePatient outcomesSurgical volumeSurgical proceduresMAIN OUTCOMESurvival advantageEquivalent Survival Between Lobectomy and Segmentectomy for Clinical Stage IA Lung Cancer
Onaitis MW, Furnary AP, Kosinski AS, Feng L, Boffa D, Tong BC, Cowper P, Jacobs JP, Wright CD, Habib R, Putnam JB, Fernandez FG. Equivalent Survival Between Lobectomy and Segmentectomy for Clinical Stage IA Lung Cancer. The Annals Of Thoracic Surgery 2020, 110: 1882-1891. PMID: 32119855, DOI: 10.1016/j.athoracsur.2020.01.020.Peer-Reviewed Original ResearchConceptsThoracic Surgeons databaseSurgeons databaseLung cancerSimilar survivalClinical stage IA lung cancerClinical stage IA diseaseStage IA lung cancerEarly-stage lung cancerPositron emission tomography resultsThoracic Surgeons General Thoracic Surgery DatabaseStage IA diseaseGeneral Thoracic Surgery DatabaseLung cancer patientsMediastinal staging proceduresThoracic Surgery DatabaseLong-term survivalIA diseaseN0 patientsStaging procedureOncologic efficacyCox regressionEntire cohortCancer patientsClinical variablesEquivalent survivalSurgically Managed Signet Ring Cell Esophageal Carcinomas in the National Cancer Database
Sathe TS, Resio BJ, Hoag JR, Monsalve AF, Pathak R, Blasberg JD, Mase V, Dhanasopon A, Boffa DJ. Surgically Managed Signet Ring Cell Esophageal Carcinomas in the National Cancer Database. The Annals Of Thoracic Surgery 2020, 109: 1656-1662. PMID: 32109449, DOI: 10.1016/j.athoracsur.2020.01.021.Peer-Reviewed Original ResearchConceptsSignet ring cell adenocarcinomaNational Cancer DatabaseSRC tumorsACA patientsCancer DatabaseProportional hazards regression modelsCommon histologic variantRole of esophagectomyClinical stage IRole of surgeryHazards regression modelsHigh-grade tumorsSRC histologySRC patientsAdult patientsComplete resectionWorse prognosisCell adenocarcinomaEsophageal cancerEsophageal carcinomaHistologic variantsSuperior survivalEsophageal adenocarcinomaTreatment characteristicsClinical recommendations
2019
Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma
Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2019, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedCohort StudiesDatabases, FactualDisease-Free SurvivalFemaleHumansImmunotherapyKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPneumonectomyPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisTumor MicroenvironmentConceptsTumor immune microenvironmentImmune microenvironmentLung adenocarcinomaOverall survivalRisk groupsMast cellsCox proportional hazard modelingEarly-stage lung adenocarcinomaLow-risk subtypesKaplan-Meier analysisPathological staging systemProportional hazard modelingImproved clinical outcomesCancer immune microenvironmentImmune cell typesEarly lung adenocarcinomaActivation stateClinical outcomesValidation cohortMacrophage contentStaging systemMultivariable modelCIBERSORT analysisPatientsClinical decisionThe Society of Thoracic Surgeons General Thoracic Surgery Database: 2019 Update on Research
Crabtree TD, Boffa DJ, Lobdell KW, Habib RH, Gaissert HA. The Society of Thoracic Surgeons General Thoracic Surgery Database: 2019 Update on Research. The Annals Of Thoracic Surgery 2019, 108: 1293-1298. PMID: 31520641, DOI: 10.1016/j.athoracsur.2019.09.001.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchDatabases, FactualHumansSocieties, MedicalThoracic SurgeryThoracic Surgical ProceduresTreatment OutcomeUnited StatesComparison of Survival Rates After a Combination of Local Treatment and Systemic Therapy vs Systemic Therapy Alone for Treatment of Stage IV Non–Small Cell Lung Cancer
Uhlig J, Case MD, Blasberg JD, Boffa DJ, Chiang A, Gettinger SN, Kim HS. Comparison of Survival Rates After a Combination of Local Treatment and Systemic Therapy vs Systemic Therapy Alone for Treatment of Stage IV Non–Small Cell Lung Cancer. JAMA Network Open 2019, 2: e199702. PMID: 31433481, PMCID: PMC6707019, DOI: 10.1001/jamanetworkopen.2019.9702.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdolescentAdultAgedAged, 80 and overAntineoplastic AgentsCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantComparative Effectiveness ResearchDatabases, FactualFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMiddle AgedNeoplasm MetastasisNeoplasm StagingPneumonectomyProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesSurvival RateTreatment OutcomeYoung AdultConceptsStage IV non-small cell lung cancerNon-small cell lung cancerPrimary tumor siteSuperior overall survivalSystemic therapySurgical resectionCell lung cancerExternal beam radiotherapyOverall survivalSurvival benefitLocal treatmentTumor siteTumor characteristicsLung cancerTreatment groupsMultivariable Cox proportional hazards regression modelsOligometastatic non-small cell lung cancerStage IV squamous cell carcinomaSurvival rateCox proportional hazards regression modelProportional hazards regression modelsComparative effectiveness research studyCancer-specific factorsNational Cancer DatabaseStage IV diseaseWhat’s Lost in What’s Missing: A Thoughtful Approach to Missing Data in the National Cancer Database
Boffa DJ. What’s Lost in What’s Missing: A Thoughtful Approach to Missing Data in the National Cancer Database. Annals Of Surgical Oncology 2019, 26: 709-710. PMID: 30603815, DOI: 10.1245/s10434-018-07130-9.Peer-Reviewed Original Research
2018
Lack of correlation between short- and long-term performance after lung cancer surgery
Fernandez FG, Kosinski AS, Tong BC, Furnary AP, Feng L, Onaitis M, Boffa D, Wright CD, Cowper P, Jacobs JP, Habib RH, Putnam JB. Lack of correlation between short- and long-term performance after lung cancer surgery. Journal Of Thoracic And Cardiovascular Surgery 2018, 157: 1633-1643.e3. PMID: 30635179, DOI: 10.1016/j.jtcvs.2018.09.141.Peer-Reviewed Original ResearchConceptsLung cancer surgeryStandardized incidence ratiosCancer surgeryLong-term survivalPerioperative morbidityIncidence ratiosPathologic stage I lung cancerStage I lung cancerThoracic Surgeons General Thoracic Surgery DatabaseI lung cancerPerioperative major morbidityGeneral Thoracic Surgery DatabaseLong-term time pointsSeparate multivariable modelsSafety of surgeryThoracic Surgery DatabaseMajor morbidityOncologic efficacyLung cancerSurgery DatabaseMultivariable modelStudy populationSurgeryMorbidityTime points
2017
Using the National Cancer Database for Outcomes Research: A Review
Boffa DJ, Rosen JE, Mallin K, Loomis A, Gay G, Palis B, Thoburn K, Gress D, McKellar DP, Shulman LN, Facktor MA, Winchester DP. Using the National Cancer Database for Outcomes Research: A Review. JAMA Oncology 2017, 3: 1722-1728. PMID: 28241198, DOI: 10.1001/jamaoncol.2016.6905.Peer-Reviewed Original ResearchEffectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians
Arnold BN, Thomas DC, Rosen JE, Salazar MC, Detterbeck FC, Blasberg JD, Boffa DJ, Kim AW. Effectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians. Surgery 2017, 162: 640-651. PMID: 28697883, DOI: 10.1016/j.surg.2017.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overCarcinoma, Non-Small-Cell LungConfidence IntervalsDatabases, FactualDisease-Free SurvivalFemaleGeriatric AssessmentHumansKaplan-Meier EstimateLogistic ModelsLung NeoplasmsMaleMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingOdds RatioPneumonectomyProportional Hazards ModelsRadiotherapyRegistriesRisk AssessmentSecondary PreventionSurvival AnalysisConceptsCell lung cancerLocal therapyLung cancerStage IRelative survivalStereotactic body radiation therapyNational Cancer DatabaseBetter overall survivalBody radiation therapyOlder patientsOverall survivalPatient ageYounger patientsOverall mortalityPrimary outcomeCancer DatabaseTreatment outcomesTreatment decisionsRadiation therapyPatientsTherapyCancerNonagenariansTreatmentSurvival
2016
Defining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery
Thomas DC, Arnold BN, Rosen JE, Salazar MC, Blasberg JD, Detterbeck FC, Boffa DJ, Kim AW. Defining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery. Lung Cancer 2016, 103: 75-81. PMID: 28024700, DOI: 10.1016/j.lungcan.2016.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCombined Modality TherapyDatabases, FactualFemaleGuidelines as TopicHumansLung NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm StagingOutcome Assessment, Health CarePneumonectomyPostoperative PeriodRadiotherapySmall Cell Lung CarcinomaSurvival AnalysisConceptsStage I small cell lung cancerClinical stage ISmall cell lung cancerCell lung cancerAdjuvant chemotherapySurgical resectionPathologic upstagingStage IRadiation therapyNodal diseaseLung cancerPositive lymph node involvementNational Cancer DatabaseOutcomes of patientsLymph node involvementProportion of patientsCurative intentNodal upstagingSCLC patientsUpstaged patientsAdjuvant therapyNode involvementIndependent predictorsInferior survivalT descriptor