2024
Salvage lung resection after immunotherapy is feasible and safe
Nemeth A, Canavan M, Zhan P, Udelsman B, Ely S, Wigle D, Martin L, Yang C, Boffa D, Dhanasopon A. Salvage lung resection after immunotherapy is feasible and safe. JTCVS Open 2024, 20: 141-150. PMID: 39296459, PMCID: PMC11405986, DOI: 10.1016/j.xjon.2024.03.018.Peer-Reviewed Original ResearchNon-small cell lung cancerComplete pathologic responseSalvage lung resectionNational Cancer DatabaseLength of stayStages I-IVLung resectionOligo-progressionOverall survivalSalvage surgeryComplete resection (R0Comprehensive multidisciplinary treatment planHigher R0 resection rateCohort study of patientsInitiation of immunotherapyR0 resection rateTreated with immunotherapySalvage treatment optionMortality rateCell lung cancerLow patient morbidityMedian length of stayKaplan-Meier analysisMultidisciplinary treatment planStudy of patients
2022
Utilization and Outcomes of Radiation in Stage IV Esophageal Cancer
Zhan P, Canavan M, Ermer T, Pichert M, Li A, Maduka R, Kaminski M, Johung K, Boffa D. Utilization and Outcomes of Radiation in Stage IV Esophageal Cancer. JTO Clinical And Research Reports 2022, 3: 100429. PMID: 36483656, PMCID: PMC9722471, DOI: 10.1016/j.jtocrr.2022.100429.Peer-Reviewed Original ResearchStage IV esophageal cancerNational Cancer DatabaseEsophageal cancerCancer DatabaseRadiation doseSurvival advantageMedian total radiation dosePropensity score-matched pairsOutcome of radiationRetrospective cohort studyKaplan-Meier analysisTotal radiation doseAppropriate radiation dosePalliative regimensCohort studyMedian ageRadiation administrationSurvival associationsBetter survivalPatientsLocal controlCancerDosePalliationFurther studiesNonregional Lymph Nodes as the Only Metastatic Site in Stage IV Esophageal Cancer
Zhan P, Canavan M, Ermer T, Pichert M, Li A, Maduka R, Kaminski M, Boffa D. Nonregional Lymph Nodes as the Only Metastatic Site in Stage IV Esophageal Cancer. JTO Clinical And Research Reports 2022, 3: 100426. PMID: 36444359, PMCID: PMC9700291, DOI: 10.1016/j.jtocrr.2022.100426.Peer-Reviewed Original ResearchStage IV esophageal cancerNonregional lymph nodesEsophageal cancerSystemic metastasesLymph nodesMultiorgan metastasesOrgan metastasisSuperior survivalAcademic facility typesOnly metastatic siteNational Cancer DatabaseOutcomes of patientsPatients 18 yearsRetrospective cohort studyStage IV diseaseKaplan-Meier analysisSquamous cell carcinomaPropensity-matched sampleNonregional lymphCohort studyMetastatic involvementMetastatic sitesCell carcinomaCancer DatabaseCox model
2019
Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma
Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2019, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedCohort StudiesDatabases, FactualDisease-Free SurvivalFemaleHumansImmunotherapyKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPneumonectomyPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisTumor MicroenvironmentConceptsTumor immune microenvironmentImmune microenvironmentLung adenocarcinomaOverall survivalRisk groupsMast cellsCox proportional hazard modelingEarly-stage lung adenocarcinomaLow-risk subtypesKaplan-Meier analysisPathological staging systemProportional hazard modelingImproved clinical outcomesCancer immune microenvironmentImmune cell typesEarly lung adenocarcinomaActivation stateClinical outcomesValidation cohortMacrophage contentStaging systemMultivariable modelCIBERSORT analysisPatientsClinical decisionProphylactic cranial irradiation is associated with improved survival following resection for limited stage small cell lung cancer
Resio BJ, Hoag J, Chiu A, Monsalve A, Dhanasopon AP, Boffa DJ, Blasberg JD. Prophylactic cranial irradiation is associated with improved survival following resection for limited stage small cell lung cancer. Journal Of Thoracic Disease 2019, 11: 811-818. PMID: 31019769, PMCID: PMC6462708, DOI: 10.21037/jtd.2019.01.64.Peer-Reviewed Original ResearchSmall cell lung cancerProphylactic cranial irradiationNational Cancer DatabaseCell lung cancerSurgical resectionCranial irradiationLymph nodesLung cancerLimited stage small cell lung cancerStage small cell lung cancerAppropriate adjuvant chemotherapyInitial surgical resectionMultivariable Cox modelNegative lymph nodesNode-positive patientsPositive lymph nodesCox multivariable analysisSubset of patientsKaplan-Meier analysisMonths of resectionHazard of deathAdjuvant chemotherapyCranial radiationBrain metastasesPreoperative chemotherapy