Criteria for Reducing Unnecessary Testing for Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus, and Enterovirus in Cerebrospinal Fluid Samples from Adults
Wilen CB, Monaco CL, Hoppe-Bauer J, Jackups R, Bucelli RC, Burnham CA. Criteria for Reducing Unnecessary Testing for Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus, and Enterovirus in Cerebrospinal Fluid Samples from Adults. Journal Of Clinical Microbiology 2015, 53: 887-895. PMID: 25568435, PMCID: PMC4390640, DOI: 10.1128/jcm.03161-14.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCerebrospinal FluidCohort StudiesCosts and Cost AnalysisCytomegalovirusEnterovirusHerpesvirus 3, HumanHumansLeukocyte CountLeukocytes, MononuclearMeningitis, AsepticMiddle AgedMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesRetrospective StudiesSensitivity and SpecificitySimplexvirusConceptsNucleic acid amplification testingVaricella-zoster virusCerebrospinal fluid samplesHSV-1/2Unnecessary testingHerpes simplex virus 1/2Retrospective observational studyCells/Fluid samplesComputerized order setsHerpes simplex virusHealth care costsNAAT assaysImmunocompetent adultsImmunocompetent subjectsValidation cohortAmplification testingObservational studyPositive testCSF samplesEV testingSimplex virusLimited followClinical specificityCare costs