Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins
Neklesa TK, Tae HS, Schneekloth AR, Stulberg MJ, Corson TW, Sundberg TB, Raina K, Holley SA, Crews CM. Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins. Nature Chemical Biology 2011, 7: 538-543. PMID: 21725302, PMCID: PMC3139752, DOI: 10.1038/nchembio.597.Peer-Reviewed Original ResearchConceptsFusion proteinHaloTag fusion proteinsProtein functionTransmembrane proteinProteinNew toolChemical spaceDegradationTags