Targeting Nucleotides Dependency Via SIRT3 Inhibition to Overcome Metabolic Plasticity and Flexibility of Dlbcls
Li M, Park N, Mlynarczyk C, Chin C, Davidson S, Melnick A. Targeting Nucleotides Dependency Via SIRT3 Inhibition to Overcome Metabolic Plasticity and Flexibility of Dlbcls. Blood 2024, 144: 2787-2787. DOI: 10.1182/blood-2024-208466.Peer-Reviewed Original ResearchDe novo biosynthesisMetabolic flexibilityTCA cycleDe novo biosynthesis of nucleotidesCarbon pathwaysMetabolic adaptationBiosynthesis of nucleotidesMitochondrial protein deacetylaseMetabolic stressNucleotide synthesis pathwaySIRT3 inhibitionLevels of nucleotidesTCA cycle metabolitesAlternative nutrient sourcesUsage of glucoseNucleotide biosynthesisNucleotide availabilityMetabolic needsCombinatorial treatmentProtein deacetylaseMetabolic plasticitySalvage pathwayLymphoma cellsMetabolic dependenciesMitochondrial enzymes