2007
Conditional deletion of the homeobox gene Hhex in the mouse liver results in polycystic liver disease
Hunter M, Wilson C, Kaestner K, Bogue C. Conditional deletion of the homeobox gene Hhex in the mouse liver results in polycystic liver disease. The FASEB Journal 2007, 21: lb4-lb4. DOI: 10.1096/fasebj.21.6.lb4.Peer-Reviewed Original ResearchAdult mutant miceHepatic cystsMutant miceNormal biliary cellsMultiple hepatic cystsIntrahepatic bile ductsDuctal plate malformationPolycystic liver diseaseBlood serum levelsWeeks of ageEmbryonic day 18.5Cystic epithelial cellsDuct-like structuresBiliary injuryCre-loxP systemSerum levelsLiver diseaseBile ductBiliary originPortal tractsTotal bilirubinAlanine transferaseCytokeratin antibodiesDay 18.5Liver results
2000
Hex expression suggests a role in the development and function of organs derived from foregut endoderm
Bogue C, Ganea G, Sturm E, Ianucci R, Jacobs H. Hex expression suggests a role in the development and function of organs derived from foregut endoderm. Developmental Dynamics 2000, 219: 84-89. PMID: 10974674, DOI: 10.1002/1097-0177(2000)9999:9999<::aid-dvdy1028>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary ductsMature animalsMaintenance of functionThymus originatesAdult thyroidDorsal pancreatic budLung expressionBile ductBiliary ductsThymic expressionFunction of organsDuct epitheliumLungThyroidE16.5 embryosLiverEpithelial cellsThymusSeptum transversumMesenchymal cellsPotential roleHex expressionDetectable levelsPharyngeal pouchesOrgans