Featured Publications
Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.
Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1419-1429. PMID: 32603604, PMCID: PMC7667912, DOI: 10.1164/rccm.202004-0991oc.Peer-Reviewed Original ResearchConceptsCF lung diseaseHealthy control subjectsImmune dysfunctionLung diseaseCystic fibrosisControl subjectsSputum cellsAbnormal chloride transportLung mononuclear phagocytesInnate immune dysfunctionDivergent clinical coursesImmune cell repertoireMonocyte-derived macrophagesCF monocytesAirway inflammationClinical courseProinflammatory featuresCell survival programInflammatory responseTissue injuryCell repertoireImmune functionTranscriptional profilesAlveolar macrophagesMononuclear phagocytes
2021
Cytokine profiles in severe SARS-CoV-2 infection requiring extracorporeal membrane oxygenation support
Kaman K, Azmy V, Chichra A, Britto-Leon C, Price C. Cytokine profiles in severe SARS-CoV-2 infection requiring extracorporeal membrane oxygenation support. Respiratory Medicine Case Reports 2021, 33: 101376. PMID: 33680800, PMCID: PMC7925237, DOI: 10.1016/j.rmcr.2021.101376.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenation supportMembrane oxygenation supportVV-ECMOOxygenation supportCytokine stormVeno-venous extracorporeal membrane oxygenation supportSevere SARS-CoV-2 infectionSARS-CoV-2 infectionVV-ECMO supportRefractory respiratory failureProspective cohort studyCohort of patientsInterleukin-2 receptorCytokine elevationHyperinflammatory stateECMO supportRespiratory failureCohort studyCytokine profileClinical courseInterleukin-10COVID19 patientsUnderlying pathophysiologyInterleukin-6Inflammatory response