2013
Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains
Jian J, Zhao S, Tian Q, Gonzalez-Gugel E, Mundra J, Uddin S, Liu B, Richbourgh B, Brunetti R, Liu C. Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains. FEBS Letters 2013, 587: 3428-3436. PMID: 24070898, PMCID: PMC3826980, DOI: 10.1016/j.febslet.2013.09.024.Peer-Reviewed Original Research
2009
ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor
Bai X, Wang D, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg H, Yu X, Liu C. ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor. Molecular And Cellular Biology 2009, 29: 4201-4219. PMID: 19487464, PMCID: PMC2715794, DOI: 10.1128/mcb.00056-09.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAMTS7 ProteinAnimalsBlotting, WesternBone and BonesBone DevelopmentCell DifferentiationCell LineCell Line, TumorChondrocytesGene Expression ProfilingHumansImmunohistochemistryImmunoprecipitationIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutParathyroid Hormone-Related ProteinProgranulinsProtein BindingProtein PrecursorsReverse Transcriptase Polymerase Chain ReactionTissue Culture TechniquesTwo-Hybrid System TechniquesConceptsADAMTS-7Granulin-epithelin precursorEndochondral bone formationEndochondral bone growthGrowth factorBone formationChondrocyte differentiationBone growthDirect targetAutocrine growth factorGrowth plate chondrocytesProteolytic activityPTHrPChondrogenic growth factorsChondrocyte hypertrophyExtracellular matrix proteinsCartilage extracellular matrix proteinsImportant targetADAMTS familyInhibitionSkeletal developmentMatrix proteinsExpression patternsExtracellular matrixArthritis
2007
RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer*
Kong L, Yu X, Bai X, Zhang W, Zhang Y, Zhao W, Jia J, Tang W, Zhou Y, Liu C. RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer*. Journal Of Biological Chemistry 2007, 282: 26381-26391. PMID: 17616526, DOI: 10.1074/jbc.m702195200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCaspase 3Caspase 8Cell Line, TransformedCell Line, TumorCell Transformation, ViralCellular SenescenceCyclin DCyclinsElectrophoresis, Gel, Two-DimensionalFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHeLa CellsHuman papillomavirus 16HumansMiceMice, NudeNeoplasm TransplantationNuclear ProteinsOncogene Proteins, ViralPapillomavirus E7 ProteinsPhenotypeProto-Oncogene Proteins c-mycRepressor ProteinsRetinoblastoma ProteinRetinoblastoma-Binding Protein 4RNA, Small InterferingTumor Suppressor Protein p53Uterine Cervical DysplasiaUterine Cervical NeoplasmsConceptsCervical cancerH8 cellsCyclin D1Critical mediatorHuman papillomavirus infectionCervical cancer CaSki cellsTumor formationCervical cancer-derived cell linesCervical intraepithelial neoplasiaHuman papillomavirus type 16Papillomavirus type 16Cancer-derived cell linesSenescence-like phenotypePapillomavirus infectionIntraepithelial neoplasiaEnzyme caspase-3Cervical carcinogenesisType 16Nude miceCaSki cellsCancerTumor suppressor retinoblastomaOncogenic genesProtein 4Cell proliferation