Featured Publications
Association Between Progranulin and Gaucher Disease
Jian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, Wang G, Chen Y, Liang F, Overkleeft HS, Saunders-Pullman R, Chan GL, Liu CJ. Association Between Progranulin and Gaucher Disease. EBioMedicine 2016, 11: 127-137. PMID: 27515686, PMCID: PMC5049935, DOI: 10.1016/j.ebiom.2016.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesAnimalsCase-Control StudiesDisease Models, AnimalEnzyme ActivationFemaleGaucher DiseaseGene FrequencyGenetic Association StudiesGenotypeHumansIntercellular Signaling Peptides and ProteinsLysosomesMaleMiceMice, KnockoutMiddle AgedMutationPhenotypePolymorphism, Single NucleotideProgranulinsProtein TransportConceptsGD patientsHealthy controlsGaucher diseaseGRN genePGRN KO miceSerum PGRN levelsPGRN-deficient miceHealthy control samplesSerum levelsPGRN levelsGaucher-like cellsKO miceTherapeutic effectRecombinant PGRNGeneral populationPatientsAnimal modelsBone marrowGBA1 geneLysosomal localizationProgranulin geneNull micePGRNDiseaseMice
2008
p204 Protein Overcomes the Inhibition of Core Binding Factor α-1–mediated Osteogenic Differentiation by Id Helix-Loop-Helix Proteins
Luan Y, Yu X, Yang N, Frenkel S, Chen L, Liu C. p204 Protein Overcomes the Inhibition of Core Binding Factor α-1–mediated Osteogenic Differentiation by Id Helix-Loop-Helix Proteins. Molecular Biology Of The Cell 2008, 19: 2113-2126. PMID: 18287524, PMCID: PMC2366862, DOI: 10.1091/mbc.e07-10-1057.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAmino Acid SequenceAnimalsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsCell DifferentiationCell LineCell NucleusCore Binding Factor alpha SubunitsFemaleHelix-Loop-Helix MotifsHumansInhibitor of Differentiation ProteinsMiceMice, Inbred BALB CNuclear Export SignalsNuclear ProteinsOsteoblastsOsteocalcinOsteogenesisPhosphoproteinsPromoter Regions, GeneticProteasome Endopeptidase ComplexProtein BindingProtein TransportTransforming Growth Factor betaUbiquitinConceptsD proteinsOsteogenic differentiationSequence-specific bindingUbiquitin-proteasome pathwayCore binding factor αExpression of Cbfa1Factor alpha 1P204 proteinExport signalHelix proteinsHelix-LoopRegulatory circuitsTarget genesInterferon-inducible proteinOsteocalcin geneMolecular mechanismsALP activityOsteoblast differentiationDiminished transcriptionCytoplasmic translocationId2Cbfa1Differentiation proteinProteinAlkaline phosphatase