2024
Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity
Sahu D, Gupta C, Yennamalli R, Sharma S, Roy S, Hasan S, Gupta P, Sharma V, Kashyap S, Kumar S, Dwivedi V, Zhao X, Panda A, Das H, Liu C. Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity. Scientific Reports 2024, 14: 12935. PMID: 38839973, PMCID: PMC11153517, DOI: 10.1038/s41598-024-63790-6.Peer-Reviewed Original ResearchConceptsProtein-protein interactionsGel mobility-shift assaysCollagen-induced arthritisMobility-shift assaysCell surface receptorsFluorescence-activated cell sortingSequence strandsBinding of TNFIn silico methodsCell deathMouse modelSurface receptorsNuclear translocationTrimer formationCell culture assaysRheumatoid arthritisVicious cycle of inflammationModel of collagen-induced arthritisTumor necrosis factor-aCell sortingMouse model of collagen-induced arthritisA549 cellsCycle of inflammationInflammatory bone destructionCulture assay
2011
Progranulin: A promising therapeutic target for rheumatoid arthritis
Liu C. Progranulin: A promising therapeutic target for rheumatoid arthritis. FEBS Letters 2011, 585: 3675-3680. PMID: 21550343, PMCID: PMC3162080, DOI: 10.1016/j.febslet.2011.04.065.Peer-Reviewed Original ResearchConceptsTNF receptorRheumatoid arthritisAntagonist of TNFαInflammatory arthritis modelPathogenesis of arthritisPromising therapeutic targetAutocrine growth factorNew therapeutic interventionsInflammatory arthritisArthritis modelInflammatory cytokinesArthritisTherapeutic targetTherapeutic interventionsProgranulinCell surface receptorsGrowth factorExtracellular matrix proteinsSurface receptorsReceptorsAtsttrinProteolytic enzymesMatrix proteinsInflammationCytokines