2011
GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation
Wang D, Bai X, Tian Q, Lai Y, Lin E, Shi Y, Mu X, Feng J, Carlson C, Liu C. GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation. Cellular And Molecular Life Sciences 2011, 69: 1855-1873. PMID: 22179841, PMCID: PMC3319484, DOI: 10.1007/s00018-011-0901-5.Peer-Reviewed Original ResearchConceptsMyoD transcription factorGranulin-epithelin precursorTranscription factorsMyoblast fusionMyotube formationMuscle-specific transcription factorsC2C12 myoblast fusionE-box sequenceSkeletal muscle differentiationFusion of myoblastsNegative feedback loopGrowth factorEmbryonic developmentRegulatory regionsMuscle differentiationSkeletal muscle tissueC2C12 myoblastsRegulatory loopSiRNA approachNovel mediatorAutocrine growth factorJunBKnockdown miceMyoblastsTissue repairProgranulin: A promising therapeutic target for rheumatoid arthritis
Liu C. Progranulin: A promising therapeutic target for rheumatoid arthritis. FEBS Letters 2011, 585: 3675-3680. PMID: 21550343, PMCID: PMC3162080, DOI: 10.1016/j.febslet.2011.04.065.Peer-Reviewed Original ResearchConceptsTNF receptorRheumatoid arthritisAntagonist of TNFαInflammatory arthritis modelPathogenesis of arthritisPromising therapeutic targetAutocrine growth factorNew therapeutic interventionsInflammatory arthritisArthritis modelInflammatory cytokinesArthritisTherapeutic targetTherapeutic interventionsProgranulinCell surface receptorsGrowth factorExtracellular matrix proteinsSurface receptorsReceptorsAtsttrinProteolytic enzymesMatrix proteinsInflammationCytokines
2009
ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor
Bai X, Wang D, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg H, Yu X, Liu C. ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor. Molecular And Cellular Biology 2009, 29: 4201-4219. PMID: 19487464, PMCID: PMC2715794, DOI: 10.1128/mcb.00056-09.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAMTS7 ProteinAnimalsBlotting, WesternBone and BonesBone DevelopmentCell DifferentiationCell LineCell Line, TumorChondrocytesGene Expression ProfilingHumansImmunohistochemistryImmunoprecipitationIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutParathyroid Hormone-Related ProteinProgranulinsProtein BindingProtein PrecursorsReverse Transcriptase Polymerase Chain ReactionTissue Culture TechniquesTwo-Hybrid System TechniquesConceptsADAMTS-7Granulin-epithelin precursorEndochondral bone formationEndochondral bone growthGrowth factorBone formationChondrocyte differentiationBone growthDirect targetAutocrine growth factorGrowth plate chondrocytesProteolytic activityPTHrPChondrogenic growth factorsChondrocyte hypertrophyExtracellular matrix proteinsCartilage extracellular matrix proteinsImportant targetADAMTS familyInhibitionSkeletal developmentMatrix proteinsExpression patternsExtracellular matrixArthritis
2007
Cartilage Oligomeric Matrix Protein Associates with Granulin-Epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation*
Xu K, Zhang Y, Ilalov K, Carlson C, Feng J, Di Cesare P, Liu C. Cartilage Oligomeric Matrix Protein Associates with Granulin-Epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation*. Journal Of Biological Chemistry 2007, 282: 11347-11355. PMID: 17307734, DOI: 10.1074/jbc.m608744200.Peer-Reviewed Original ResearchConceptsGranulin-epithelin precursorCartilage oligomeric matrix proteinMutant cartilage oligomeric matrix proteinTwo-hybrid systemCo-immunoprecipitation assaysFunctional genetic screensChondrocyte proliferationHuman cartilage oligomeric matrix proteinGenetic screenRat chondrosarcoma cellsProtein associatesGrowth factorRepeat domainBiological functionsFunctional domainsMouse embryosMatrix proteinsAnti-COMP antibodiesChondrosarcoma cellsOligomeric matrix proteinAutocrine growth factorMultiple epiphyseal dysplasiaPericellular matrixPrimary human chondrocytesRepeat units