2020
Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation
Zerra PE, Arthur CM, Chonat S, Maier CL, Mener A, Shin S, Allen JWL, Baldwin WH, Cox C, Verkerke H, Jajosky RP, Tormey CA, Meeks SL, Stowell SR. Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation. Frontiers In Immunology 2020, 11: 905. PMID: 32582142, PMCID: PMC7295897, DOI: 10.3389/fimmu.2020.00905.Peer-Reviewed Original ResearchConceptsAnti-FVIII antibody formationAnti-FVIII antibodiesKnockout recipientsAntibody formationWT recipientsFc gamma receptorsAnti-FVIII antibody developmentGamma receptorsRole of FcγRsFVIII exposureAntibody levelsWT miceTherapeutic optionsAntibody responseC3 knockoutTarget antigenHemophilia AImmune systemFcγRAntibody developmentInfusionRecipientsAntibodiesPotential mechanismsPatients
2009
Clinical trials for pathogen reduction in transfusion medicine: A review
McClaskey J, Xu M, Snyder EL, Tormey CA. Clinical trials for pathogen reduction in transfusion medicine: A review. Transfusion And Apheresis Science 2009, 41: 217-225. PMID: 19793679, DOI: 10.1016/j.transci.2009.09.008.Peer-Reviewed Original ResearchConceptsClinical trialsBlood productsDonor screening programsDonor blood productsRisk of transmissionInfective donorsTransfusion recipientsScreening programClinical settingInfectious diseasesTransfusion medicineTesting regimensPI treatmentTrialsScreening assaysRiskPathogensPotential toxicityPromising strategyDetection of pathogensRegimensPathogen reductionSensitive methodDiseaseRecipients