Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsChristopher T Rentsch, PhD, FISPE
Associate Professor AdjunctDownloadHi-Res Photo
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Titles
Associate Professor Adjunct
Positions outside Yale
Associate Professor, London School of Hygiene & Tropical Medicine, London School of Hygiene & Tropical Medicine
Biography
Dr Rentsch is an epidemiologist specialising in the use of electronic health records, with a focus on establishing real-world evidence for the safety and effectiveness of medications.
In his roles within the Veterans Aging Cohort Study (VACS) at Yale and the Electronic Health Records (EHR) Research Group at London School of Hygiene & Tropical Medicine, he performs research using some of the largest clinical and genetic cohorts in the world today.
Dr Rentsch has received two prestigious awards from the International Society for Pharmacoepidemiology (ISPE) in 2021 (Emerging Leader Award) and 2022 (Special ISPE Award for his "demonstrable impact on public health related to the COVID-19 pandemic"). In 2024, he was named a Fellow of the International Society of Pharmacoepidemiology and elected to the ISPE Board of Directors.
Dr Rentsch is Co-Chair of the VACS Pharmacoepidemiology Core and Program Director for pharmacoepidemiology and pharmacovigilance training at LSHTM, including:
- Professional Certificate in Pharmacoepidemiology & Pharmacovigilance
- Real-World Evidence in Pharmacoepidemiology
Dr Rentsch was co-Editor of a free, online textbook, "COVID-19 Real-World Evidence Primer," which aims to promote careful design and methodological approaches supporting causal inferences on drug safety and effectiveness that guide clinical and regulatory decisions.
In his spare time, he can be found performing around the UK in the London City Brass band.
Last Updated on November 27, 2024.
Appointments
General Internal Medicine
Associate Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- London School of Hygiene & Tropical Medicine (2018)
- MPH
- Emory University (2011)
- BA
- The Ohio State University (2008)
Research
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Research Projects
Prescription Stimulants for Attention-Deficit/Hyperactivity Disorder (ADHD): Prescribing Patterns and Associated Consequences in the Veterans Health Administration
Internal Medicine / , parent organization of General Internal Medicine
ORCID
0000-0002-1408-7907
Publications
2026
Beyond data and technology: the need for new thinking to enable the era of precision prevention
Tsakiroglou M, Harish P, Hemingway H, Blagden S, Gardner S, O’Connor D, Rentsch C, Ford G, Saoulidis A, Maclean R, Denniston A, Pirmohamed M. Beyond data and technology: the need for new thinking to enable the era of precision prevention. BMC Medicine 2026 PMID: 42135719, DOI: 10.1186/s12916-026-04938-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsRisk of type 2 diabetes mellitus after treatment with direct-acting antivirals for hepatitis C virus in people with HIV
Chalouni M, Torgersen J, Rentsch C, Van Santen D, Jarrin I, Klein M, Young J, Gill M, Epstein R, Linas B, Zangerle R, Surial B, Nemeth J, Touloumi G, Papadopoulos A, Wittkop L, Van Der Valk M, Boyd A, Monforte A, Puoti M, Logan R, Rein S, Miro J, Berenguer J, Hernán M, Lodi S. Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for hepatitis C virus in people with HIV. AIDS 2026, 40: 1073-1081. PMID: 41879095, PMCID: PMC13111791, DOI: 10.1097/qad.0000000000004499.Peer-Reviewed Original ResearchAltmetricBridging genomics and pharmacoepidemiology to expand treatment options for alcohol use disorder
Rentsch C, Malone S, Shi M, Setzer M, Piserchia Z, Winterlind E, Farokhnia M, Tazare J, Justice A, Fiellin D, Leggio L, Kranzler H, Gray J. Bridging genomics and pharmacoepidemiology to expand treatment options for alcohol use disorder. Alcohol Clinical And Experimental Research 2026, 50: e70247. PMID: 41811207, DOI: 10.1111/acer.70247.Peer-Reviewed Original ResearchCitationsAltmetricQuantifying selection bias due to unobserved patients in pharmacoepidemiologic studies of severe COVID-19 cohorts
Bokern M, Rentsch C, Quint J, Schultze A, Douglas I. Quantifying selection bias due to unobserved patients in pharmacoepidemiologic studies of severe COVID-19 cohorts. BMC Medical Research Methodology 2026, 26: 34. PMID: 41540342, PMCID: PMC12896000, DOI: 10.1186/s12874-025-02732-w.Peer-Reviewed Original Research
2025
Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study
Mason A, Fatih N, Sofat R, Rentsch C, Smeeth L, Bhaskaran K, Chaturvedi N, Garfield V. Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study. Diabetes Obesity And Metabolism 2025, 28: 1741-1749. PMID: 41388643, PMCID: PMC12890726, DOI: 10.1111/dom.70353.Peer-Reviewed Original ResearchCitationsAltmetricAssociations Between Prior and Current Unhealthy Alcohol Use and Liver Morbidity Risk and Mortality Among Veterans With a History of Hepatitis C Who Have Achieved Sustained Virological Response
Feelemyer J, Ban F, Braithwaite R, Bhattacharya D, Caniglia E, Justice A, Lim J, Re V, Scheidell J, Rentsch C, Khan M. Associations Between Prior and Current Unhealthy Alcohol Use and Liver Morbidity Risk and Mortality Among Veterans With a History of Hepatitis C Who Have Achieved Sustained Virological Response. Journal Of Viral Hepatitis 2025, 33: e70116. PMID: 41376520, DOI: 10.1111/jvh.70116.Peer-Reviewed Original ResearchAltmetricHigh‐Throughput Screening Using the Self‐Controlled Tree‐Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury
Re V, Newcomb C, Carbonari D, Leonard C, Rentsch C, Maro J. High‐Throughput Screening Using the Self‐Controlled Tree‐Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. Pharmacoepidemiology And Drug Safety 2025, 34: e70275. PMID: 41345999, PMCID: PMC12678845, DOI: 10.1002/pds.70275.Peer-Reviewed Original ResearchConcurrent Alcohol Use and the Relative Risk of Community‐Acquired Pneumonia Associated With Anticholinergic and Non‐Anticholinergic Neurocognitively Active Medication Receipt: A National Nested Case–Control Study Among US Veterans
Wang W, Crothers K, Akgün K, Gordon K, Rodriguez‐Barradas M, Womack J, Thompson J, Justice A, Rentsch C. Concurrent Alcohol Use and the Relative Risk of Community‐Acquired Pneumonia Associated With Anticholinergic and Non‐Anticholinergic Neurocognitively Active Medication Receipt: A National Nested Case–Control Study Among US Veterans. Pharmacoepidemiology And Drug Safety 2025, 34: e70279. PMID: 41340437, PMCID: PMC12676203, DOI: 10.1002/pds.70279.Peer-Reviewed Original ResearchCitationsApplying High‐Dimensional Propensity Scores in a Study of Inhaled Corticosteroids and COVID‐19 Outcomes
Bokern M, Tazare J, Rentsch C, Quint J, Douglas I, Schultze A. Applying High‐Dimensional Propensity Scores in a Study of Inhaled Corticosteroids and COVID‐19 Outcomes. Pharmacoepidemiology And Drug Safety 2025, 34: e70248. PMID: 41287049, PMCID: PMC12644305, DOI: 10.1002/pds.70248.Peer-Reviewed Original ResearchRisk of Hepatocellular Carcinoma After Direct-Acting Antiviral Treatment for Hepatitis C Virus Infection in People With HIV
van Santen D, Chalouni M, Berenguer J, Jarrin I, Miró J, Klein M, Young J, Torgersen J, Rentsch C, Gill M, Epstein R, Nunes D, Surial B, Rauch A, Touloumi G, Papadopoulos A, Wittkop L, Gilbert C, Leleux O, van der Valk M, Boyd A, Monforte A, Puoti M, Zangerle R, Gisinger M, Logan R, Rein S, Hernán M, Lodi S. Risk of Hepatocellular Carcinoma After Direct-Acting Antiviral Treatment for Hepatitis C Virus Infection in People With HIV. Clinical Infectious Diseases 2025, 82: e942-e950. PMID: 41253696, PMCID: PMC13075511, DOI: 10.1093/cid/ciaf635.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Activities
activity COVID-19 Core
2021 - PresentAdvisory BoardsCo-ChairDetailsVeterans Aging Cohort Study (VACS), US Dept of Veterans Affairsactivity Pharmacoepidemiology (PEPI) Core
2022 - PresentAdvisory BoardsCo-ChairDetailsVeterans Aging Cohort Study (VACS), US Dept of Veterans Affairsactivity ISPE Board of Directors
2024 - PresentAdvisory BoardsBoard of DirectorsDetailsInternational Society for Pharmacoepidemiology (ISPE)activity Anti(retro)viral Therapy Workgroup
2015 - 2022Advisory BoardsCo-ChairDetailsVeterans Aging Cohort Study (VACS), US Dept of Veterans Affairsactivity Polypharmacy Workgroup
2019 - 2022Advisory BoardsCo-ChairDetailsVeterans Aging Cohort Study (VACS), US Dept of Veterans Affairs
Honors
honor FISPE (Fellow of the International Society of Pharmacoepidemiology)
04/22/2024International AwardInternational Society of Pharmacoepidemiologyhonor Special ISPE Award for Contributions to Public Health Associated with the COVID-19 Pandemic
08/27/2022International AwardInternational Society for PharmacoepidemiologyDetailsUnited Kingdomhonor Emerging Leader Award
08/25/2021International AwardInternational Society for PharmacoepidemiologyDetailsUnited Kingdomhonor Best Reviewer Award
07/01/2017International AwardPharmacoepidemiology & Drug SafetyDetailsUnited Kingdom
News
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News
- January 02, 2025
Yale Department of Internal Medicine Faculty Promotions and Appointments (January 2025)
- March 11, 2024
Excess Deaths During the COVID-19 Pandemic
- February 02, 2023Source: NIH National Institute on Drug Abuse Intramural Research Program
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies