2015
Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice
Kolodin D, van Panhuys N, Li C, Magnuson A, Cipolletta D, Miller C, Wagers A, Germain R, Benoist C, Mathis D. Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice. Cell Metabolism 2015, 21: 543-557. PMID: 25863247, PMCID: PMC4747251, DOI: 10.1016/j.cmet.2015.03.005.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueTreg compartmentT cellsAccumulation of regulatory T cellsConventional CD4(+) T cellsCD4(+) T cellsRegulatory T cellsAdipose tissueMHC class II moleculesEpidemic of obesityClass II moleculesAntigen receptor repertoireWeeks of lifeConsequent metabolic abnormalitiesIndolent proliferationsVAT-TregRegulatory TLean miceMetabolic abnormalitiesLocal inflammationLymphoid organsSoluble mediatorsLean individualsMetabolic indicesPhenotypic conversion
2011
Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells
Hettmer S, Liu J, Miller C, Lindsay M, Sparks C, Guertin D, Bronson R, Langenau D, Wagers A. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 20002-20007. PMID: 22135462, PMCID: PMC3250188, DOI: 10.1073/pnas.1111733108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCell LineageCell ProliferationCell SeparationCell Transformation, NeoplasticGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmunohistochemistryMiceMice, Inbred C57BLMuscle CellsMuscle DevelopmentMuscle Fibers, SkeletalMuscle NeoplasmsMuscle, SkeletalRas ProteinsRatsSarcomaSignal TransductionTOR Serine-Threonine KinasesTranscriptomeConceptsMechanistic target of rapamycinRhabdomyosarcoma cells in vitroHuman rhabdomyosarcomaTumor cell of originKirsten rat sarcoma viral oncogeneCyclin-dependent kinase inhibitor 2AIsolated skeletal muscle cellsRat sarcoma viral oncogeneChimeric mouse modelSoft tissue sarcomasIsolated satellite cellsCell of originMechanistic target of rapamycin signalingCells in vitroGene expression signaturesMesenchymal cell lineagesConsistent with activationSkeletal muscle cellsMyogenic featuresTissue-specific differentiation markersPleomorphic rhabdomyosarcomaCluster of genesInhibition of RasTarget of rapamycinHeterogeneous cancer