2024
Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce
Willis Z, Oliveira C, Abzug M, Anosike B, Ardura M, Bio L, Boguniewicz J, Chiotos K, Downes K, Grapentine S, Hersh A, Heston S, Hijano D, Huskins W, James S, Jones S, Lockowitz C, Lloyd E, MacBrayne C, Maron G, McDonough M, Miller C, Morton T, Olivero R, Orscheln R, Schwenk H, Singh P, Soma V, Sue P, Vora S, Nakamura M, Wolf J. Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce. Journal Of The Pediatric Infectious Diseases Society 2024, 13: 159-185. PMID: 38339996, PMCID: PMC11494238, DOI: 10.1093/jpids/piad116.Peer-Reviewed Original ResearchConceptsRisk factorsRisk stratificationPediatric intensive care medicineEffects of therapyNon-hospitalized childrenPediatric infectious diseasesSevere COVID-19Cases of infectionMeta-analysis of dataIntensive care medicineClinical characteristicsPreventive therapyPediatric populationManagement of COVID-19Fatal infectionConsensus statementSevere illnessTherapyMeta-analysisTherapeutic interventionsSARS-CoV-2Expert consensusCare medicineRe-convenedGuidance statements
2023
Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report
Miller C, Taylor-Salmon E, Emuren L, Landry M, Gershon A, Miller G. Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report. BMC Infectious Diseases 2023, 23: 854. PMID: 38057696, PMCID: PMC10698951, DOI: 10.1186/s12879-023-08809-5.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusVZV reactivationVaccine-strain varicella-zoster virusSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Latent varicella zoster virusSymptomatic COVID-19 infectionRespiratory syndrome coronavirus 2SARS-CoV2 infectionSyndrome coronavirus 2COVID-19 infectionVaccine-type strainsSARS-CoV-2Vesicular rashPediatric patientsSignificant morbidityClinical syndromeCoronavirus 2Single doseCase reportGeneral populationMechanical traumaDisease processHZ casesPhysiologic stress
2022
Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data
Fashina T, Miller C, Paintsil E, Niccolai L, Brandt C, Oliveira C. Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data. Journal Of The Pediatric Infectious Diseases Society 2022, 12: 113-116. PMID: 36548966, PMCID: PMC9969330, DOI: 10.1093/jpids/piac132.Peer-Reviewed Original Research
2013
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
Loffredo F, Steinhauser M, Jay S, Gannon J, Pancoast J, Yalamanchi P, Sinha M, Dall’Osso C, Khong D, Shadrach J, Miller C, Singer B, Stewart A, Psychogios N, Gerszten R, Hartigan A, Kim M, Serwold T, Wagers A, Lee R. Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy. Cell 2013, 153: 828-839. PMID: 23663781, PMCID: PMC3677132, DOI: 10.1016/j.cell.2013.04.015.Peer-Reviewed Original ResearchConceptsCardiac hypertrophyYoung miceOld miceCirculating factorsTreatment of old miceAge-related hypertrophyReduced cardiomyocyte sizeGrowth differentiation factor 11Aptamer-based proteomicsDifferentiation factor 11Blood-borne factorsReverse age-related cardiac hypertrophyCardiomyocyte sizeHeart failureSurgical techniqueHypertrophyCardiac agingHeterochronic parabiosisTherapeutic opportunitiesTGF-bFactor 11Influence of circulation factorsBehavioral effectsMiceMolecular remodeling
2012
Induction of Histiocytic Sarcoma in Mouse Skeletal Muscle
Liu J, Hettmer S, Milsom M, Hofmann I, Hua F, Miller C, Bronson R, Wagers A. Induction of Histiocytic Sarcoma in Mouse Skeletal Muscle. PLOS ONE 2012, 7: e44044. PMID: 22952867, PMCID: PMC3432091, DOI: 10.1371/journal.pone.0044044.Peer-Reviewed Original ResearchConceptsMyeloid sarcomaAcute myeloid leukemiaBone marrowHistiocytic sarcomaAccumulation of immature myeloid cellsDiagnosis of acute myeloid leukemiaEvidence of pathologic involvementEx vivo transductionImmature myeloid cellsLeukemia-initiating cellsNon-hematopoietic organsBone marrow cellsHematopoietic lineage markersSarcoma-bearing miceTumor-bearing animalsSkeletal muscleInduce tumor formationImmunocompromised NODSecondary transplantationMyeloid leukemiaPeripheral bloodMarrow cellsMyeloid cellsAbsent expressionIntravenous transplantation
2011
Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells
Hettmer S, Liu J, Miller C, Lindsay M, Sparks C, Guertin D, Bronson R, Langenau D, Wagers A. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 20002-20007. PMID: 22135462, PMCID: PMC3250188, DOI: 10.1073/pnas.1111733108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCell LineageCell ProliferationCell SeparationCell Transformation, NeoplasticGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmunohistochemistryMiceMice, Inbred C57BLMuscle CellsMuscle DevelopmentMuscle Fibers, SkeletalMuscle NeoplasmsMuscle, SkeletalRas ProteinsRatsSarcomaSignal TransductionTOR Serine-Threonine KinasesTranscriptomeConceptsMechanistic target of rapamycinRhabdomyosarcoma cells in vitroHuman rhabdomyosarcomaTumor cell of originKirsten rat sarcoma viral oncogeneCyclin-dependent kinase inhibitor 2AIsolated skeletal muscle cellsRat sarcoma viral oncogeneChimeric mouse modelSoft tissue sarcomasIsolated satellite cellsCell of originMechanistic target of rapamycin signalingCells in vitroGene expression signaturesMesenchymal cell lineagesConsistent with activationSkeletal muscle cellsMyogenic featuresTissue-specific differentiation markersPleomorphic rhabdomyosarcomaCluster of genesInhibition of RasTarget of rapamycinHeterogeneous cancer