2018
Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies
Abraham A, Brasov I, Thekkiniath J, Kilian N, Lawres L, Gao R, DeBus K, He L, Yu X, Zhu G, Graham MM, Liu X, Molestina R, Ben Mamoun C. Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies. Journal Of Biological Chemistry 2018, 293: 19974-19981. PMID: 30463941, PMCID: PMC6311517, DOI: 10.1074/jbc.ac118.005771.Peer-Reviewed Original ResearchMeSH KeywordsAntiparasitic AgentsAtovaquoneAzithromycinBabesiaBabesiosisCell Culture TechniquesClindamycinErythrocytesHumansParasitic Sensitivity TestsQuinineConceptsHuman babesiosisBetter therapeutic strategiesHigher parasite burdenTick-borne diseaseFulminant infectionRed blood cellsTherapeutic strategiesHuman erythrocytesParasite burdenClinical casesSevere pathologyHuman red blood cellsNew disease modelsBlood cellsDisease modelsInfectionDiseaseBabesiosisDeathRelevant model systemParasitesApicomplexan parasitesDaughter parasitesErythrocytesFurther research
2011
Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy
Bobenchik AM, Augagneur Y, Hao B, Hoch JC, Mamoun C. Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy. FEMS Microbiology Reviews 2011, 35: 609-619. PMID: 21303393, PMCID: PMC4107886, DOI: 10.1111/j.1574-6976.2011.00267.x.Peer-Reviewed Original ResearchConceptsStress-resistant plantsImportant biochemical stepHuman malaria parasiteMethyl donor SAMPhosphocholine biosynthesisN-methyltransferasesFlorida lanceletDependent methyltransferasesNuclear divisionBiochemical stepsDependent methylationBiological functionsGene expressionGenetic characterizationDevelopment of therapiesMalaria parasitesMajor phospholipidsDiverse groupEnzymeSmall moleculesPlantsAntiparasite therapyEukaryotesPhosphoethanolamineMethyltransferases