2023
Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus
Vasquez-Rios G, Katz R, Levitan E, Cushman M, Parikh C, Kimmel P, Bonventre J, Waikar S, Schrauben S, Greenberg J, Sarnak M, Ix J, Shlipak M, Gutierrez O. Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus. Kidney360 2023, 4: e1257-e1264. PMID: 37533144, PMCID: PMC10547219, DOI: 10.34067/kid.0000000000000226.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Monocyte chemoattractant protein-1Kidney tubule healthCause-specific mortalityUrine biomarkersYKL-40Risk factorsCardiovascular deathCause mortalityHigh riskChitinase-3-like protein 1Greater riskHigher MCP-1Higher urine levelsUrine KIM-1Injury molecule-1Cause-specific deathMortality risk factorsProportional hazards regressionRisk of deathAdditional risk factorsProtein 1Cancer-related deathChemoattractant protein-1Alpha-1-microglobulin
2016
YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation
Puthumana J, Hall IE, Reese PP, Schröppel B, Weng FL, Thiessen-Philbrook H, Doshi MD, Rao V, Lee CG, Elias JA, Cantley LG, Parikh CR. YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation. Journal Of The American Society Of Nephrology 2016, 28: 661-670. PMID: 27451287, PMCID: PMC5280016, DOI: 10.1681/asn.2016010091.Peer-Reviewed Original ResearchConceptsYKL-40 concentrationsDonor kidneysYKL-40Renal recoveryDeceased donor kidney transplantationRisk of DGFAcute tubular necrosisDeceased kidney donorsDonor kidney transplantationProspective cohort studyPoor transplant outcomesDeceased donor kidneysOrgan procurement organizationsDonor biomarkersGraft functionKidney transplantationCohort studyGraft failureTransplant outcomesTubular injuryTubular necrosisRecipient outcomesKidney donorsProcurement biopsiesPrognostic biomarker