2022
Serum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness
Lin C, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong L, Tan Y. Serum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness. Neuroscience Letters 2022, 788: 136826. PMID: 35944595, DOI: 10.1016/j.neulet.2022.136826.Peer-Reviewed Original ResearchMeSH KeywordsBrain Cortical ThicknessCognitionCognition DisordersCognitive DysfunctionHumansSchizophreniaConceptsBrain cortical thicknessCognitive impairmentCognitive deficitsGray matter thicknessSchizophrenia (MATRICS) Consensus Cognitive BatteryAttention/vigilanceConsensus Cognitive BatteryCortical thicknessSerum Hcy levelsFirst-episode patientsHealthy controlsHigh homocysteineWorking memoryHcy levelsCognitive batteryNegative Symptom ScaleCognitive functionTreatment researchHigh-resolution magnetic resonance imagingSymptom ScaleSandwich enzyme-linked immunosorbentSchizophreniaHigher cortical thicknessImpairmentEnzyme-linked immunosorbentAcute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis
Zhornitsky S, Tourjman V, Pelletier J, Assaf R, Li CR, Potvin S. Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2022, 118: 110575. PMID: 35568275, DOI: 10.1016/j.pnpbp.2022.110575.Peer-Reviewed Original ResearchMeSH KeywordsCognitionCognition DisordersHealthy VolunteersHumansKetamineMemory, Short-TermNeuropsychological TestsConceptsVerbal learningCognitive domainsResponse inhibitionAcute ketamine administrationVerbal learning/memorySpeed of processingLearning/memorySocial cognitionVerbal memoryExecutive functionVisual learningVisuospatial abilitiesMemory figuresCognitionMemoryCognitive impairmentAcute ketamineKetamine administrationEffect sizeLearningImpairmentModerate impairmentDeficitsNegative effectsHealthy individualsEmotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. American Journal Of Alzheimer's Disease & Other Dementias® 2022, 37: 15333175221082834. PMID: 35357236, PMCID: PMC9212074, DOI: 10.1177/15333175221082834.Peer-Reviewed Original ResearchConceptsEmotional processing deficitsProcessing dysfunctionProcessing deficitsMultiple behavioral paradigmsEmotional memoryEmotional stimuliPositive emotionsAltered emotionsNegative emotionsNeural correlatesEmotional processing dysfunctionAmygdala reactivityBehavioral findingsEmotional disordersCognitive deficitsBehavioral paradigmsProminent deficitsEmotionsAlzheimer's diseaseBehavioral studiesLongitudinal studyNoradrenergic signalingDeficitsCircuit dysfunctionMemory
2019
Elevated serum anti-NMDA receptor antibody levels in first-episode patients with schizophrenia
Tong J, Huang J, Luo X, Chen S, Cui Y, An H, Xiu M, Tan S, Wang Z, Yuan Y, Zhang J, Yang F, Li CR, Hong L, Tan Y. Elevated serum anti-NMDA receptor antibody levels in first-episode patients with schizophrenia. Brain Behavior And Immunity 2019, 81: 213-219. PMID: 31201848, PMCID: PMC6754783, DOI: 10.1016/j.bbi.2019.06.017.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) glutamate receptorsFirst-episode patientsNMDAR antibodiesAntibody levelsHealthy controlsSerum anti-NMDAR antibodyTotal scoreAnti-NMDAR antibodiesNMDAR antibody levelsNMDAR-antibody encephalitisElevated levelsReceptor antibody levelsSerum antibody levelsTreatment of schizophreniaPathogenesis of schizophreniaNegative Syndrome ScaleSymptoms of psychosisEnzyme-linked immunosorbentEtiology of schizophreniaMCCB total scoreAntibody encephalitisPatient groupNMDAR dysfunctionSchizophrenia (MATRICS) Consensus Cognitive BatteryGlutamate receptors
2018
Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients
Li X, Chen H, Lv Y, Chao HH, Gong L, Li CR, Cheng H. Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients. Scientific Reports 2018, 8: 13801. PMID: 30218006, PMCID: PMC6138678, DOI: 10.1038/s41598-018-32257-w.Peer-Reviewed Original ResearchConceptsBreast cancer patientsGray matter densityRight middle frontal gyrusBC patientsCancer patientsCognitive impairmentMiddle frontal gyrusChemotherapy cyclesFrontal gyrusWhole brainGray matterMorphometry analysisHealthy control subjectsStructural magnetic resonance imagingDose-response relationshipMagnetic resonance imagingRight fusiform areaFrontal cortical structuresControl subjectsBilateral cerebellumInferior frontal gyrusPatientsLeft inferior frontal gyrusResonance imagingBrain structures
2016
Power spectrum scale invariance as a neural marker of cocaine misuse and altered cognitive control
Ide JS, Hu S, Zhang S, Mujica-Parodi LR, Li CS. Power spectrum scale invariance as a neural marker of cocaine misuse and altered cognitive control. NeuroImage Clinical 2016, 11: 349-356. PMID: 27294029, PMCID: PMC4888196, DOI: 10.1016/j.nicl.2016.03.004.Peer-Reviewed Original ResearchConceptsPower spectrum scale invarianceCognitive controlInferior frontal gyrusNeural markersBehavioral adjustmentSupramarginal gyrusLeft inferior frontal gyrusFunctional magnetic resonance imagingFronto-parietal areasBlood oxygenation level-dependent (BOLD) signalCocaine misuseLevel-dependent signalCocaine-dependent adultsSignal taskFrontal gyrusFrontoparietal regionsPrefrontal cortexMagnetic resonance imagingConnectivity dynamicsBehavioral variablesCerebral activityCocaine addictionCocaine exposureCocaine dependenceDependent adults
2015
Resting‐state functional connectivity of the striatum in early‐stage Parkinson's disease: Cognitive decline and motor symptomatology
Manza P, Zhang S, Li C, Leung H. Resting‐state functional connectivity of the striatum in early‐stage Parkinson's disease: Cognitive decline and motor symptomatology. Human Brain Mapping 2015, 37: 648-662. PMID: 26566885, PMCID: PMC4843498, DOI: 10.1002/hbm.23056.Peer-Reviewed Original ResearchConceptsParkinson's diseaseFunctional connectivity patternsMotor deficitsFunctional connectivityRostral anterior cingulate cortexState functional connectivity patternsAnterior cingulate cortexConnectivity patternsAnterior putamenMotor symptomsSubstantia nigraDopaminergic functionHealthy controlsMotor functionDorsal caudateStriatal connectivityStriatal subregionsSymptomatic individualsMotor impairmentCingulate cortexCognitive declineNeurodegenerative disordersCognitive functionDiseaseEarly stage individuals
2013
Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCerebral CortexCocaine-Related DisordersCognition DisordersFemaleHumansImage Processing, Computer-AssistedInhibition, PsychologicalMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedModels, NeurologicalNeural PathwaysNeuropsychological TestsOxygenPhotic StimulationReaction TimeConceptsFunctional magnetic resonance imagingStop-signal taskCD individualsCerebral activationPrecuneus/posterior cingulate cortexSystolic blood pressureInfluence of methylphenidateEffects of methylphenidateMagnetic resonance imagingPosterior cingulate cortexBrain imaging studiesCocaine-addicted individualsDefault mode networkAgonist therapyBlood pressureIntravenous methylphenidateCortico-striatoHealthy controlsCocaine-dependent individualsThalamic activationCingulate cortexResonance imagingBrain regionsMethylphenidateCocaine dependence
2006
Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence
Li CS, Milivojevic V, Kemp K, Hong K, Sinha R. Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. Drug And Alcohol Dependence 2006, 85: 205-212. PMID: 16725282, DOI: 10.1016/j.drugalcdep.2006.04.008.Peer-Reviewed Original ResearchConceptsImpaired response inhibitionStop-signal taskResponse inhibitionCognitive processesCocaine-dependent patientsSignal taskResponse readinessTask-related cognitive processesCritical cognitive mechanismsPerformance monitoringMeasures of impulsivityEducation-matched healthy controlsSignal reaction timeAbstinent cocaine-dependent patientsHorse-race modelCognitive mechanismsPSS effectCocaine subjectsRace modelHealthy controlsSubstance abusersAbstinent patientsSSRTStop signalCocaine dependence
2005
Recent cannabis abuse decreased stress-induced BOLD signals in the frontal and cingulate cortices of cocaine dependent individuals
Li CS, Milivojevic V, Constable RT, Sinha R. Recent cannabis abuse decreased stress-induced BOLD signals in the frontal and cingulate cortices of cocaine dependent individuals. Psychiatry Research 2005, 140: 271-280. PMID: 16290108, DOI: 10.1016/j.pscychresns.2005.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultCocaine-Related DisordersCognition DisordersFemaleFrontal LobeGyrus CinguliHumansMaleMarijuana AbuseOxygenStress, PsychologicalTime FactorsConceptsPerigenual anterior cingulateAbstinent cocaine-dependent subjectsCocaine-dependent subjectsCannabis abuseCannabis abusersCocaine-dependent individualsAnterior cingulateEmotional stressBOLD signalUrine drug screeningSame statistical thresholdDrug use historyFrontal cortical areasHeavy cannabis useLevel-dependent contrastPrevious neuroimaging studiesFunctional magnetic resonanceFrontal cortexCortical areasAlcohol consumptionCortical activationEmotional stress taskUse of marijuanaBrain regionsDecreased activation
2004
Do schizophrenia patients make more perseverative than non-perseverative errors on the Wisconsin Card Sorting Test? A meta-analytic study
Li CS. Do schizophrenia patients make more perseverative than non-perseverative errors on the Wisconsin Card Sorting Test? A meta-analytic study. Psychiatry Research 2004, 129: 179-190. PMID: 15590045, DOI: 10.1016/j.psychres.2004.06.016.Peer-Reviewed Original ResearchMeSH KeywordsCognition DisordersHumansInhibition, PsychologicalNeuropsychological TestsSchizophreniaSeverity of Illness IndexTime FactorsConceptsSchizophrenia patientsWisconsin Card Sorting TestNon-perseverative errorsCard Sorting TestStudy of patientsInhibitory functionSorting TestHealthy controlsPatientsPerseverative errorsHealthy participantsSchizophreniaExecutive functionMeta-analytic studyMarginal levelsComparable numberHigher number
2002
Impairment of temporal attention in patients with schizophrenia
Li CS, Lin WH, Yang YY, Huang CC, Chen TW, Chen YC. Impairment of temporal attention in patients with schizophrenia. Neuroreport 2002, 13: 1427-1430. PMID: 12167767, DOI: 10.1097/00001756-200208070-00016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAttentionCognition DisordersFemaleHumansMalePhotic StimulationSchizophreniaConceptsRapid serial visual presentation taskCore cognitive deficitVisual presentation taskEducation-matched control subjectsNumber of distractorsSignal detection theoryAttentional blinkT2 detectionTemporal attentionPresentation taskAttention impairmentVisual stimuliTemporal deploymentCognitive deficitsDetection theorySchizophrenia patientsSchizophrenia subjectsRapid successionSchizophreniaImpairmentTemporal gatingAttentionDistractorsBlinkStimuli