2024
Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes
Chaudhary S, Wong H, Chen Y, Zhang S, Li C. Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes. Biology Of Sex Differences 2024, 15: 15. PMID: 38351045, PMCID: PMC10863151, DOI: 10.1186/s13293-024-00591-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyAnxiety DisordersEmotionsFemaleHumansMagnetic Resonance ImagingMalePrefrontal CortexSex CharacteristicsConceptsMedial prefrontal cortexState-Trait Anxiety InventoryFunctional magnetic resonance imagingState-Trait Anxiety Inventory scoresSuperior frontal gyrusGeneralized psychophysiological interactionEmotional processingFrontal gyrusLingual gyrusMedial prefrontal cortex connectivityMedial prefrontal cortex activationSex differencesRight inferior frontal gyrusResponse to negative emotionsRight superior frontal gyrusFunctional magnetic resonance imaging dataReaction timeImpact emotional processingNegative emotion processingInferior frontal gyrusLeft parahippocampal gyrusNegative emotional scenesMarkers of anxietyRepeated-measures analysis of covarianceLevels of anxiety
2023
Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss
Li G, Li Y, Zhang Z, Chen Y, Li B, Hao D, Yang L, Yang Y, Li X, Li C. Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss. Journal Of Psychiatric Research 2023, 162: 11-20. PMID: 37062201, PMCID: PMC10225357, DOI: 10.1016/j.jpsychires.2023.04.013.Peer-Reviewed Original Research
2022
Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariatesGray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability
Chen Y, Ide JS, Li CS, Chaudhary S, Le TM, Wang W, Zhornitsky S, Zhang S, Li C. Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability. Human Brain Mapping 2022, 43: 2634-2652. PMID: 35212098, PMCID: PMC9057091, DOI: 10.1002/hbm.25810.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildFemaleGray MatterHumansImpulsive BehaviorMagnetic Resonance ImagingMaleSex CharacteristicsConceptsGray matter volumeImpulsivity traitsPositive urgencyVolumetric correlatesSensation seekingHigher positive urgencyMid-cingulate cortexSex differencesVoxel-based morphometry analysisSmaller gray matter volumeImpulsivity dimensionsSubsample of twinsDistinct correlatesCingulate cortexPrecentral gyrusSubcortical gray matter volumesMatter volumeTotal intracranial volumeSeekingImpulsivityMorphometry analysisPrevious researchInsulaCorrelatesGirls
2021
Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace S, Rossetti MG, Allen N, Batalla A, Bellani M, Brambilla P, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Labuschagne I, Momenan R, Martin-Santos R, Rendell P, Solowij N, Sinha R, Li CR, Schmaal L, Sjoerds Z, Suo C, Terrett G, van Holst RJ, Veltman DJ, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Lorenzetti V. Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry 2021, 11: 156. PMID: 33664226, PMCID: PMC7933136, DOI: 10.1038/s41398-021-01204-1.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAmygdalaFemaleHippocampusHumansMagnetic Resonance ImagingMaleNeuroanatomySex CharacteristicsConceptsENIGMA Addiction Working GroupAlcohol dependenceAmygdala subregionsAlcohol-dependent malesUnderlying neurobiological mechanismsSex differencesSubfield volumesTotal amygdalaAlcohol doseBasolateral nucleusAnimal modelsMale controlsWorking GroupAmygdalar subregionsMental healthNeurobiological mechanismsComparison groupCognitive problemsHippocampusMalesFemalesDistinct mechanismsLittle evidenceGroupAmygdalaSex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
Dhingra I, Zhang S, Zhornitsky S, Wang W, Le TM, Li CR. Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neuroscience 2021, 22: 12. PMID: 33639845, PMCID: PMC7913329, DOI: 10.1186/s12868-021-00618-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticipation, PsychologicalBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPunishmentRewardSex CharacteristicsConceptsMonetary incentive delay taskFunctional magnetic resonance imagingNeural responsesSex differencesReward-related brain activationBilateral orbitofrontal cortexMagnetic resonance imagingIncentive delay taskWhole-brain regressionVisual cortexResonance imagingOrbitofrontal cortexBrain activationWomenSuccess rateFMRI studyMenDelay taskImaging literatureNeural sensitivityCortexNeural basisAffective functionsHigher SR scoresLarge wins
2020
Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group
Rabin RA, Mackey S, Parvaz MA, Cousijn J, Li C, Pearlson G, Schmaal L, Sinha R, Stein E, Veltman D, Thompson PM, Conrod P, Garavan H, Alia‐Klein N, Goldstein RZ. Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group. Human Brain Mapping 2020, 43: 543-554. PMID: 32857473, PMCID: PMC8675419, DOI: 10.1002/hbm.25141.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral CortexCocaine-Related DisordersFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingSex CharacteristicsConceptsGray matter volumeCocaine useCocaine-dependent individualsMatter volumeCD individualsWhole-brain linear regressionAnterior insulaHippocampal gray matter volumeSelect brain areasT1-weighted MRI scansGender-specific associationsTotal intracranial volumeENIGMA Addiction Working GroupCue-induced cravingLeft anterior insulaGender-specific mechanismsAge-matched participantsCD menCD womenVoxel-based morphometry dataControl menLimbic regionsClinical dataMRI scansBrain areasNeural responses to negative facial emotions: Sex differences in the correlates of individual anger and fear traits
Li G, Zhang S, Le TM, Tang X, Li CR. Neural responses to negative facial emotions: Sex differences in the correlates of individual anger and fear traits. NeuroImage 2020, 221: 117171. PMID: 32682098, PMCID: PMC7789231, DOI: 10.1016/j.neuroimage.2020.117171.Peer-Reviewed Original ResearchConceptsNegative facial emotionsFacial emotionsMiddle frontal cortexShape targetRetrosplenial cortexEmotion processingIndividual differencesProlonged RTHigher activationRight middle frontal cortexLeft retrosplenial cortexBilateral middle frontal cortexFrontal cortexSex-specific behavioralShape identificationHuman Connectome ProjectRegional brain responsesEmotion measuresAffective traitsNeural processesBrain responsesFear traitsNeural responsesEmotional disordersIndividuals' anger
2018
Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers
Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestResting-state functional connectivityThalamic connectivityCaudate connectivityFrontal associationThalamic dysfunctionCaudate headProblem drinkingWhole-brain linear regressionAE scoreSubcortical structuresFunctional connectivityBilateral caudate headRight caudate headDisorders Identification TestSex differencesThalamic subdivisionsThalamic subregionsParietal associationAlcohol misuseThalamusWhite matter tractographyAUDIT scoresNondependent drinkersAlcohol expectanciesThalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use
Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR. Thalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 868-877. PMID: 29859929, PMCID: PMC6177312, DOI: 10.1016/j.bpsc.2018.04.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAlcoholismBrainBrain MappingFemaleHumansLactationMagnetic Resonance ImagingMaleSex CharacteristicsYoung AdultConceptsWhole-brain linear regressionError-related activationSex differencesBilateral dorsal anterior cingulate cortexAlcohol Use Disorders Identification Test (AUDIT) scoresSocial drinkersDorsal anterior cingulate cortexSubstance use disordersAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingSuperior temporal cortexStatistical parametric mappingProblem alcohol useBilateral thalamusAlcohol drinkersAdult social drinkersStop-signal taskMale social drinkersTemporal cortexUse disordersCerebral activationIndependent sample t-testCingulate cortexSubcortical regionsResting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers
Hu S, Ide JS, Chao HH, Zhornitsky S, Fischer KA, Wang W, Zhang S, Li CR. Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers. Drug And Alcohol Dependence 2018, 185: 173-180. PMID: 29454928, PMCID: PMC5889735, DOI: 10.1016/j.drugalcdep.2017.11.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcoholismAmygdalaBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetPrefrontal CortexSex CharacteristicsConceptsState functional connectivityDorsal anterior cingulate cortexAlcohol misuseAlcohol drinkersFunctional connectivityInvolvement scoreProblem drinkingSubstance useWhole-brain rsFCComorbid substance useAmygdala-prefrontal cortical circuitAnterior cingulate cortexStatistical parametric mappingPotential sex differencesPrefrontal cortical structuresAmygdala connectivityCortical functionCortical circuitsCingulate cortexAmygdalaCortical structuresParametric mappingSex differencesDrinkingDrinkers
2017
Depression in chronic ketamine users: Sex differences and neural bases
Li CR, Zhang S, Hung CC, Chen CM, Duann JR, Lin CP, Lee TS. Depression in chronic ketamine users: Sex differences and neural bases. Psychiatry Research Neuroimaging 2017, 269: 1-8. PMID: 28892733, PMCID: PMC5634929, DOI: 10.1016/j.pscychresns.2017.09.001.Peer-Reviewed Original ResearchConceptsHealthy controlsSgACC connectivityChronic ketamine usersKetamine usersOrbitofrontal cortexEpidemiological Studies Depression ScaleSubgenual anterior cingulate cortexSex differencesPathogenesis of depressionCES-D scoresState functional connectivityBilateral superior temporal gyrusChronic ketamine useAnterior cingulate cortexSuperior temporal gyrusNeural basisDepression ScaleDorsomedial prefrontal cortexDepression scoresDepression severityKetamine useCingulate cortexTemporal gyrusFunctional connectivityPrefrontal cortexSex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study
Ide JS, Zhornitsky S, Hu S, Zhang S, Krystal JH, Li CR. Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study. NeuroImage Clinical 2017, 14: 750-759. PMID: 28413777, PMCID: PMC5385596, DOI: 10.1016/j.nicl.2017.03.015.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesGray matter volumeAlcohol expectanciesAlcohol Use Disorders Identification TestSocial drinkersNon-dependent social drinkersProblem drinkingRole of impulsivityBrain imaging studiesRight posterior insulaSex differencesStructural brain imagingStructural brain imaging studiesNeural basisDisorders Identification TestBarratt impulsivityPsychological factorsImpulsivityMediation analysisPosterior insulaDependent individualsRisk factorsAlcohol misuseLinear modelingGeneral linear modeling
2015
Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age
Zhang S, Hu S, Chao HH, Li CR. Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age. Cerebral Cortex 2015, 26: 3413-3427. PMID: 26223261, PMCID: PMC4961017, DOI: 10.1093/cercor/bhv172.Peer-Reviewed Original ResearchConceptsVentral tegmental area/substantia nigra pars compactaSubstantia nigra pars compactaLocus coeruleusPars compactaFunctional connectivityResting-state functional connectivityCerebral functional connectivityNumerous animal studiesFronto-parietal cortexRight anterior insulaResting-state fMRI dataEffect of ageCerebral cortexNoradrenergic inputCognitive motor controlAnimal studiesCortex decreasesHealthy adultsCerebellum increasesMidbrain nucleiBilateral amygdalaMidbrain structuresAnterior insulaCognitive manifestationsMotor control
2014
Resting state functional connectivity of the basal nucleus of Meynert in humans: In comparison to the ventral striatum and the effects of age
Li CS, Ide JS, Zhang S, Hu S, Chao HH, Zaborszky L. Resting state functional connectivity of the basal nucleus of Meynert in humans: In comparison to the ventral striatum and the effects of age. NeuroImage 2014, 97: 321-332. PMID: 24736176, PMCID: PMC4065805, DOI: 10.1016/j.neuroimage.2014.04.019.Peer-Reviewed Original ResearchConceptsCerebral functional connectivityFunctional connectivityStronger positive connectivityEffect of ageMotor areaBasal nucleusCognitive declineState functional magnetic resonanceResting-state functional magnetic resonancePositive connectivityPrimary cholinergic inputLoss of neuronsPost-mortem human brainState functional connectivitySupplementary motor areaNumerous animal studiesPre-supplementary motor areaReward-Related BehaviorAnterior cingulate cortexMedial orbitofrontal cortexAge-related cognitive declineAge-related changesFunctional magnetic resonanceVS connectivityCerebral cortexError-related functional connectivity of the thalamus in cocaine dependence
Zhang S, Hu S, Bednarski SR, Erdman E, Li CS. Error-related functional connectivity of the thalamus in cocaine dependence. NeuroImage Clinical 2014, 4: 585-592. PMID: 24936409, PMCID: PMC4053644, DOI: 10.1016/j.nicl.2014.01.015.Peer-Reviewed Original ResearchConceptsVentral medial prefrontal cortexFunctional connectivityCognitive controlGeneralized psychophysiological interaction analysisTask-related processesPsychophysiological interaction analysisSubgenual anterior cingulate cortexCocaine dependenceMedial prefrontal cortexAnterior cingulate cortexError processingExecutive functionCocaine-dependent patientsPrefrontal cortexCingulate cortexRelated activationSubstance misuseCocaine useDrug useThalamic connectivity
2013
Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: Duration of use and gender difference
Ide JS, Zhang S, Hu S, Sinha R, Mazure CM, Li CS. Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: Duration of use and gender difference. Drug And Alcohol Dependence 2013, 134: 51-62. PMID: 24090712, PMCID: PMC3865077, DOI: 10.1016/j.drugalcdep.2013.09.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCerebral CortexCocaine-Related DisordersEcho-Planar ImagingFemaleHumansMaleMiddle AgedSex CharacteristicsTime FactorsYoung AdultConceptsGray matter volumeSuperior frontal gyrusDuration of useGM volumeMatter volumeLow-frequency fluctuationsBOLD signalCingulate cortexCD individualsCocaine useCerebral gray matter volumeAlcohol useMiddle/posterior cingulate cortexRight superior frontal gyrusGM volume lossBilateral superior frontal gyrusHealthy control subjectsRight ventral putamenMagnetic resonance imagingChronic cocaine usePosterior cingulate cortexInfluence of ageEffect of ageControl subjectsVentral putamenError processing and gender-shared and -specific neural predictors of relapse in cocaine dependence
Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM, Hong KI, Sinha R, Mazure CM, Li CS. Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 2013, 136: 1231-1244. PMID: 23485852, PMCID: PMC3613717, DOI: 10.1093/brain/awt040.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexFunctional magnetic resonance imagingCognitive controlError-related activationError processingCocaine-dependent individualsAnterior cingulate cortexSignal taskCingulate cortexCocaine dependenceFunctional magnetic resonance imaging (fMRI) dataStop-signal taskTreatment-seeking individualsCross-sectional findingsModerate-sized cohortsBrain activationBehavioral treatmentNeural predictorsDrug useMagnetic resonance imaging dataStatistical Parametric Mapping 8Regional activationPsychosocial factorsSuccess trialsMagnetic resonance imagingGray matter volume correlates of global positive alcohol expectancy in non‐dependent adult drinkers
Ide JS, Zhang S, Hu S, Matuskey D, Bednarski SR, Erdman E, Farr OM, Li C. Gray matter volume correlates of global positive alcohol expectancy in non‐dependent adult drinkers. Addiction Biology 2013, 19: 895-906. PMID: 23461484, PMCID: PMC3681829, DOI: 10.1111/adb.12046.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAnticipation, PsychologicalFemaleFrontal LobeGray MatterHumansMagnetic Resonance ImagingMaleSex CharacteristicsConceptsGM volumeVoxel-based morphometrySuperior frontal gyrusPrecentral gyrusBilateral superior frontal gyrusBilateral dorsolateral prefrontal cortexStructural brain changesNumerous imaging studiesLeft precentral gyrusGray matter volumeDrinking behaviorRight ventral putamenDorsolateral prefrontal cortexNon-dependent drinkersStructural brain correlatesVentral putamenBrain changesFrontal cortexGray matter correlatesMatter volumeNon-dependent drinkingRecent drinkingImaging studiesInfluence drinking behaviorPrefrontal cortex
2006
Gender differences in the neural correlates of response inhibition during a stop signal task
Li CS, Huang C, Constable RT, Sinha R. Gender differences in the neural correlates of response inhibition during a stop signal task. NeuroImage 2006, 32: 1918-1929. PMID: 16806976, DOI: 10.1016/j.neuroimage.2006.05.017.Peer-Reviewed Original ResearchConceptsStop-signal taskBrain activationResponse inhibitionGreater activationSignal taskAnterior cingulate cortexRegional brain activationNeural correlatesCognitive-motor tasksGender differencesFunctional magnetic resonanceStop-signal inhibitionMotor thalamusGlobus pallidusSubcortical areasYears of educationMotor circuitryCingulate cortexBrain regionsCaudate tailMotor tasksWomenSuccess rateLower statistical thresholdMen