2024
Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampus
2022
Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking
Le TM, Malone T, Li CR. Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking. Drug And Alcohol Dependence 2022, 231: 109248. PMID: 34998254, PMCID: PMC8881788, DOI: 10.1016/j.drugalcdep.2021.109248.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPositive alcohol expectanciesAlcohol expectanciesInsular connectivityFunctional connectivityWhole-brain multiple regressionPath analysisNegative emotion processingVentromedial prefrontal cortexSuperior parietal lobuleSuperior frontal gyrusCognitive controlAlcohol stimuliEmotion processingPrefrontal structuresStimulus saliencyFrontal gyrusDrinking motivationsMotivational circuitsInsula connectivityParietal lobuleAdult drinkersPrefrontal cortexInsulaDrinking behavior
2021
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans
Angarita GA, Worhunsky PD, Naganawa M, Toyonaga T, Nabulsi NB, Li C, Esterlis I, Skosnik PD, Radhakrishnan R, Pittman B, Gueorguieva R, Potenza MN, Finnema SJ, Huang Y, Carson RE, Malison RT. Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans. Addiction Biology 2021, 27: e13123. PMID: 34852401, PMCID: PMC8891080, DOI: 10.1111/adb.13123.Peer-Reviewed Original ResearchConceptsCocaine use disorderAnterior cingulate cortexRecent cocaine useSynaptic densityMedial orbitofrontal cortexPrefrontal cortexCocaine useOrbitofrontal cortexUse disordersVentromedial prefrontal cortexPositron emission tomography scanPositron emission tomography studyEmission tomography scanSynaptic vesicle glycoprotein 2AHealthy control subjectsVolume of distributionEmission tomography studiesAcute cocaineControl subjectsTomography scanCocaine exposurePreclinical studiesHC subjectsDendritic spinesLifetime cocaine use
2020
Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving
Zhang S, Zhornitsky S, Wang W, Dhingra I, Le TM, Li CR. Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving. Drug And Alcohol Dependence 2020, 216: 108240. PMID: 32853997, PMCID: PMC7606798, DOI: 10.1016/j.drugalcdep.2020.108240.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsHabitual drug useCocaine withdrawalCocaine cravingDrug useCue exposureNeutral cue exposureReward circuit dysfunctionCocaine Craving QuestionnaireCocaine cue exposureChronic cocaine useSex differencesCocaine-dependent participantsCircuit dysfunctionFemale CDVentromedial prefrontal cortexCocaine useCocaine addictionFunctional connectivityPrefrontal cortexDependent participantsWithdrawalHigher activationCocainePerceived burdensomeness and neural responses to ostracism in the Cyberball task
Le TM, Zhornitsky S, Wang W, Li CR. Perceived burdensomeness and neural responses to ostracism in the Cyberball task. Journal Of Psychiatric Research 2020, 130: 1-8. PMID: 32763557, PMCID: PMC7554229, DOI: 10.1016/j.jpsychires.2020.06.015.Peer-Reviewed Original ResearchConceptsCyberball taskInterpersonal needsIndividual differencesProsocial behaviorNeural responsesSocial interactionStronger neural responsesGreater brain activationDorsomedial prefrontal cortexMiddle frontal gyrusSocial exclusionResponse timeBrain activationBrain correlatesBehavioral performanceFMRI studyAnterior insulaFrontal gyrusSocial painBehavioral avoidanceAffective responsesBehavioral measuresNeural activationPrefrontal cortexEmotional distressNeural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity
Li G, Zhang S, Le TM, Tang X, Li CR. Neural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity. Cerebral Cortex Communications 2020, 1: tgaa025. PMID: 32864617, PMCID: PMC7446303, DOI: 10.1093/texcom/tgaa025.Peer-Reviewed Original ResearchGambling TaskNeural processesImpulse controlRegional activationSex differencesDorsal anterior cingulate cortexPrefrontal cortical activationAnterior cingulate cortexReaction timeHuman Connectome ProjectCautious respondingReward sensitivityIndividual variationNeural responsesBehavioral measuresAngular gyrusLonger reaction timesPrefrontal cortexImpulsivityCingulate cortexCortical activationConnectome ProjectHigher activationTaskReward
2019
Concurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation
Yang M, Tsai SJ, Li CR. Concurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation. Brain Structure And Function 2019, 225: 345-363. PMID: 31863185, PMCID: PMC6960357, DOI: 10.1007/s00429-019-02007-3.Peer-Reviewed Original ResearchConceptsActivation likelihood estimationPassive exposureAmygdala activityNegative emotionsRight amygdala activityEmotion processingPosterior cingulate cortexWhole-brain analysisPrefrontal cortical responsesCortical responsesLeft amygdalaCingulate cortexVentromedial prefrontal cortexBilateral amygdalaVentral striatumPrefrontal cortexConvergent activityAmygdalaVentral precuneusEffects of valenceCortexExposureVmPFCPositive emotionsVmPFC responsesTranscriptome-wide piRNA profiling in human brains for aging genetic factors.
Mao Q, Fan L, Wang X, Lin X, Cao Y, Zheng C, Zhang Y, Zhang H, Garcia-Milian R, Kang L, Shi J, Yu T, Wang K, Zuo L, Li CR, Guo X, Luo X. Transcriptome-wide piRNA profiling in human brains for aging genetic factors. 2019, 4 PMID: 32149191, PMCID: PMC7059831.Peer-Reviewed Original ResearchPIWI-interacting RNAsTransposable elementsAge-associated genesCritical genetic determinantsGenomic integrityExpression regulationCancer stem cellsMicroarray technologyGenetic determinantsStem cellsExpression levelsRenewal capacityMolecular featuresBiological systemsPotential roleGenetic factorsYears of survivalUnderlying mechanismHuman prefrontal cortexGermlineGenesRNADisease statusMultiple testingPrefrontal cortexThe dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression.
Chen H, Ding K, Zhao J, Chao HH, Li CR, Cheng H. The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression. American Journal Of Cancer Research 2019, 9: 1776-1785. PMID: 31497358, PMCID: PMC6726991.Peer-Reviewed Original ResearchChemotherapy-related cognitive impairmentBreast cancer patientsHormone receptor expressionDorsolateral prefrontal cortexLeft dorsolateral prefrontal cortexCancer patientsSuperior frontal gyrusReceptor expressionFunctional connectivityPrefrontal cortexEstrogen receptorLeft precuneusCognitive impairmentFunctional magnetic resonance imaging (fMRI) examinationsMagnetic resonance imaging examinationsRight superior frontal gyrusNeuropsychological testsRight dorsolateral prefrontal cortexFunctional connectivity strengthResting-state fMRI dataER-/PRBC patientsDLPFC connectivityBreast cancerImaging examinationsImaging the effects of age on proactive control in healthy adults
Hu S, Job M, Jenks SK, Chao HH, Li CR. Imaging the effects of age on proactive control in healthy adults. Brain Imaging And Behavior 2019, 13: 1526-1537. PMID: 31011949, PMCID: PMC6812594, DOI: 10.1007/s11682-019-00103-w.Peer-Reviewed Original ResearchConceptsInferior occipital gyrusStop-signal reaction timePrefrontal cortexProactive controlProactive inhibitionOlder adultsReactive inhibitionSuperior parietal lobuleSequential effectsEffect of ageSignal reaction timeCaudate headDistinct neural processesParacentral lobuleTrial reaction timeVentromedial prefrontal cortexLateral prefrontal cortexHealthy adultsNeural changesNeural plasticityOccipital gyrusParietal lobuleReaction timeYoung adultsBelief Model
2018
Structural and functional cerebral bases of diminished inhibitory control during healthy aging
Hu S, Ide JS, Chao HH, Castagna B, Fischer KA, Zhang S, Li C. Structural and functional cerebral bases of diminished inhibitory control during healthy aging. Human Brain Mapping 2018, 39: 5085-5096. PMID: 30113124, PMCID: PMC6287913, DOI: 10.1002/hbm.24347.Peer-Reviewed Original ResearchConceptsProlonged stop signal reaction timeStop-signal reaction timeAge-related reductionInhibitory controlFunctional changesPrefrontal cortexAge-related diminutionSignal taskRight dorsolateral prefrontal cortexSame brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexInferior parietal cortexResponse inhibitionDorsolateral prefrontal cortexInferior frontal cortexDiminished inhibitory controlCerebral changesStructure-function associationsSignal reaction timeCaudate headAge-related differencesStop-signal taskFrontal cortexResting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study
Zhang S, Wang W, Zhornitsky S, Li CR. Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study. Frontiers In Psychiatry 2018, 9: 344. PMID: 30100886, PMCID: PMC6072838, DOI: 10.3389/fpsyt.2018.00344.Peer-Reviewed Original ResearchState functional connectivityMedial hypothalamusHealthy controlsCocaine dependenceDorsolateral prefrontal cortexFunctional connectivityHypothalamic connectivityPrefrontal cortexVentral striatumCocaine misuseConnectivity strengthCocaine Craving QuestionnaireRole of dopamineInferior parietal lobuleLateral hypothalamusTrend-level significanceMesocorticolimbic circuitPreclinical workHypothalamusVentromedial prefrontal cortexCocaine usePast monthParietal lobuleTemporal gyrusHypothalamus functionsExploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood
Xiao T, Zhang S, Lee LE, Chao HH, van Dyck C, Li CR. Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood. Frontiers In Aging Neuroscience 2018, 10: 209. PMID: 30061823, PMCID: PMC6055042, DOI: 10.3389/fnagi.2018.00209.Peer-Reviewed Original ResearchResting-state functional connectivityAmygdala resting-state functional connectivityDorsal medial prefrontal cortexAnterior cingulate cortexAge-related differencesFunctional connectivityEmotion regulationAge-related changesPrefrontal cortexPositive resting-state functional connectivityNegative rsFCCingulate cortexEmotion regulatory mechanismsMiddle adulthoodVentromedial prefrontal cortexLife-span developmentState functional connectivityPosterior cingulate cortexMedial prefrontal cortexCognitive processingMaladaptive developmentAmygdala interactionsEmotional disordersIntrinsic connectivityAmygdala circuitsVentral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity
Zhang S, Li CR. Ventral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity. Translational Psychiatry 2018, 8: 119. PMID: 29915214, PMCID: PMC6006289, DOI: 10.1038/s41398-018-0164-0.Peer-Reviewed Original ResearchConceptsState functional connectivityCocaine dependenceVentral striatumFunctional connectivityVentral striatal dysfunctionExtent of depressionCircuit deficitsDopaminergic deficitFunctional dysconnectivityStriatal dysfunctionRSFC differencesVmPFC connectivitySubregional changesRsFC changesParahippocampal gyrusCocaine cravingCortical connectivityHealthy populationVentromedial prefrontal cortexVisual cortexMental illnessCocaine useRSFCPrefrontal cortexFunctional subregionsThe Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms
Liu L, Yao YW, Li CR, Zhang JT, Xia CC, Lan J, Ma SS, Zhou N, Fang XY. The Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms. Frontiers In Psychiatry 2018, 9: 154. PMID: 29740358, PMCID: PMC5924965, DOI: 10.3389/fpsyt.2018.00154.Peer-Reviewed Original ResearchInternet gaming disorderDorsolateral prefrontal cortexNeural mechanismsLeft amygdalaGaming disorderRight dorsolateral prefrontal cortexDepression symptomsPrecentral gyrusAutoregressive cross-lagged modelingBrain imaging researchExecutive control networkResting-state functional connectivity studyCross-lagged modelingFunctional connectivity studiesLongitudinal survey studyNeural levelBrain mechanismsEmotional deficitsPrefrontal cortexCognitive deficitsPsychotherapy interventionsControl participantsIGD severityCollege studentsConnectivity studies
2017
Depression in chronic ketamine users: Sex differences and neural bases
Li CR, Zhang S, Hung CC, Chen CM, Duann JR, Lin CP, Lee TS. Depression in chronic ketamine users: Sex differences and neural bases. Psychiatry Research Neuroimaging 2017, 269: 1-8. PMID: 28892733, PMCID: PMC5634929, DOI: 10.1016/j.pscychresns.2017.09.001.Peer-Reviewed Original ResearchConceptsHealthy controlsSgACC connectivityChronic ketamine usersKetamine usersOrbitofrontal cortexEpidemiological Studies Depression ScaleSubgenual anterior cingulate cortexSex differencesPathogenesis of depressionCES-D scoresState functional connectivityBilateral superior temporal gyrusChronic ketamine useAnterior cingulate cortexSuperior temporal gyrusNeural basisDepression ScaleDorsomedial prefrontal cortexDepression scoresDepression severityKetamine useCingulate cortexTemporal gyrusFunctional connectivityPrefrontal cortexHemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study
Zhang S, Hu S, Chao HH, Li CR. Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study. Brain Structure And Function 2017, 222: 2573-2583. PMID: 28110447, PMCID: PMC5540792, DOI: 10.1007/s00429-016-1358-y.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPosterior cingulate cortexIntraparietal sulcusVentral striatumSupramarginal gyrusVS connectivityFunctional connectivityDorsomedial prefrontal cortexAutomated Anatomic Labeling (AAL) atlasFunctional hemispheric asymmetriesCerebral functional organizationGender differencesHuman Connectome ProjectRight lateralizationSelf-ControlHemispheric lateralizationPrefrontal cortexSaliency responsesBehavioral contingenciesFunctional lateralizationMotivated behaviorHemispheric asymmetryCingulate cortexConnectome ProjectLaterality index
2016
Power spectrum scale invariance as a neural marker of cocaine misuse and altered cognitive control
Ide JS, Hu S, Zhang S, Mujica-Parodi LR, Li CS. Power spectrum scale invariance as a neural marker of cocaine misuse and altered cognitive control. NeuroImage Clinical 2016, 11: 349-356. PMID: 27294029, PMCID: PMC4888196, DOI: 10.1016/j.nicl.2016.03.004.Peer-Reviewed Original ResearchConceptsPower spectrum scale invarianceCognitive controlInferior frontal gyrusNeural markersBehavioral adjustmentSupramarginal gyrusLeft inferior frontal gyrusFunctional magnetic resonance imagingFronto-parietal areasBlood oxygenation level-dependent (BOLD) signalCocaine misuseLevel-dependent signalCocaine-dependent adultsSignal taskFrontal gyrusFrontoparietal regionsPrefrontal cortexMagnetic resonance imagingConnectivity dynamicsBehavioral variablesCerebral activityCocaine addictionCocaine exposureCocaine dependenceDependent adultsThe effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task
Manza P, Hu S, Ide JS, Farr OM, Zhang S, Leung HC, Li CR. The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task. Journal Of Psychopharmacology 2016, 30: 283-293. PMID: 26755547, PMCID: PMC4837899, DOI: 10.1177/0269881115625102.Peer-Reviewed Original ResearchConceptsUnsigned prediction errorsStop-signal taskConflict anticipationVentromedial prefrontal cortexEffects of methylphenidateDorsal anterior cingulateInferior parietal lobulePresupplementary motor areaCognitive controlHealthy young adultsNeural processesUpcoming conflictTask performanceNeural mechanismsBilateral caudate headParietal lobulePrediction errorPrefrontal cortexAnterior cingulateAdaptive behaviorParahippocampal gyrusMethylphenidateMotor areaAnticipation activityYoung adults
2015
Anticipating conflict: Neural correlates of a Bayesian belief and its motor consequence
Hu S, Ide JS, Zhang S, Li CS. Anticipating conflict: Neural correlates of a Bayesian belief and its motor consequence. NeuroImage 2015, 119: 286-295. PMID: 26095091, PMCID: PMC4564311, DOI: 10.1016/j.neuroimage.2015.06.032.Peer-Reviewed Original ResearchConceptsProactive controlMedial prefrontal cortexNeural correlatesPrefrontal cortexPre-supplementary motor areaTrial reaction timeStop-signal taskBilateral anterior insulaProlonged response timeReaction timeMotor consequencesCognitive controlConflict anticipationRT slowingSignal taskAnterior insulaTarget onsetLarge fMRI data setsPrediction errorBehavioral paradigmsBehavioral consequencesGranger causality analysisFMRI data setsBayesian beliefFMRI signals