2024
Age-related reduction in anxiety and neural encoding of negative emotional memory
Chaudhary S, Zhang S, Chen Y, Dominguez J, Chao H, Li C. Age-related reduction in anxiety and neural encoding of negative emotional memory. Frontiers In Aging Neuroscience 2024, 16: 1375435. PMID: 39021704, PMCID: PMC11252031, DOI: 10.3389/fnagi.2024.1375435.Peer-Reviewed Original ResearchNegative emotional memoriesSpielberger State-Trait Anxiety InventoryEmotional memoryAge-related reductionSpielberger State-Trait Anxiety Inventory scoresWhole-brain regressionNegative emotional imagesState-Trait Anxiety InventoryTrait Anxiety InventoryAge-related differencesSignal detection theoryMemory taskNeutral imagesAge-related changesEmotional imagesAnxiety InventoryMediation analysisAnxietyPost-scanCortical activityNeural encodingState scoresMemoryOlder adultsDetection theory
2022
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Chaudhary S, Zhornitsky S, Chao H, van Dyck C, Li C. Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls. Journal Of Alzheimer's Disease 2022, 90: 1615-1628. PMID: 36314209, PMCID: PMC10064487, DOI: 10.3233/jad-220708.Peer-Reviewed Original ResearchConceptsMiddle temporal gyrusMild cognitive impairmentMotivation circuitsFunctional connectivityPath analysisWhole-brain regressionPCu/PCCState functional connectivityTotal scoreTemporal gyrusNeural markersCingulate cortexMemory dysfunctionRSFCHealthy controlsCognitive statusCognitive impairmentAlzheimer's diseaseApathyPrecuneusMemoryRsFCsDepressionScale total scoreCognitive subscoresAcute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis
Zhornitsky S, Tourjman V, Pelletier J, Assaf R, Li CR, Potvin S. Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2022, 118: 110575. PMID: 35568275, DOI: 10.1016/j.pnpbp.2022.110575.Peer-Reviewed Original ResearchConceptsVerbal learningCognitive domainsResponse inhibitionAcute ketamine administrationVerbal learning/memorySpeed of processingLearning/memorySocial cognitionVerbal memoryExecutive functionVisual learningVisuospatial abilitiesMemory figuresCognitionMemoryCognitive impairmentAcute ketamineKetamine administrationEffect sizeLearningImpairmentModerate impairmentDeficitsNegative effectsHealthy individualsEmotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. American Journal Of Alzheimer's Disease & Other Dementias® 2022, 37: 15333175221082834. PMID: 35357236, PMCID: PMC9212074, DOI: 10.1177/15333175221082834.Peer-Reviewed Original ResearchConceptsEmotional processing deficitsProcessing dysfunctionProcessing deficitsMultiple behavioral paradigmsEmotional memoryEmotional stimuliPositive emotionsAltered emotionsNegative emotionsNeural correlatesEmotional processing dysfunctionAmygdala reactivityBehavioral findingsEmotional disordersCognitive deficitsBehavioral paradigmsProminent deficitsEmotionsAlzheimer's diseaseBehavioral studiesLongitudinal studyNoradrenergic signalingDeficitsCircuit dysfunctionMemoryClinical and behavior characteristics of individuals who used ketamine
Lee TS, Liu YH, Huang YJ, Tang WK, Wang Y, Hu S, Lin CP, Li CR, Hung CC. Clinical and behavior characteristics of individuals who used ketamine. Scientific Reports 2022, 12: 801. PMID: 35039593, PMCID: PMC8764021, DOI: 10.1038/s41598-022-04832-9.Peer-Reviewed Original ResearchConceptsMemory testLower urinary tract symptomsN-back memory testShort-term recallShort-term memoryDrug-using participantsCigarette smokersImpulsivity measuresTerm recallBehavioral dispositionsPolydrug usersKetamine usersGroup of individualsSex-related behaviorsUrinary tract symptomsPolydrug useDrug-related problemsCross-sectional interviewMemoryRisk behaviorsKetamine useTract symptomsClinical characteristicsParticipantsHIV serostatus
2020
Acute effects of partial CB1 receptor agonists on cognition – A meta-analysis of human studies
Zhornitsky S, Pelletier J, Assaf R, Giroux S, Li CR, Potvin S. Acute effects of partial CB1 receptor agonists on cognition – A meta-analysis of human studies. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2020, 104: 110063. PMID: 32791166, DOI: 10.1016/j.pnpbp.2020.110063.Peer-Reviewed Original ResearchConceptsVerbal learning/memorySpeed of processingLearning/memoryCognitive domainsResidual cognitive effectsChronic cannabis usersAcute cannabis consumptionExecutive functionCognitive effectsCannabis usersImpulsivityEffect size estimatesMemoryCognitive dysfunctionCannabis consumptionCognitionCB1 receptor agonistDeficitsModerate impairmentProcessingAnalysis of routesImpairmentIntravenous administration studyComprehensive Meta-AnalysisNegative effects