2020
Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction
Zhang S, Zhornitsky S, Wang W, Le TM, Dhingra I, Chen Y, Li C. Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction. Addiction Biology 2020, 26: e12989. PMID: 33300238, PMCID: PMC8614224, DOI: 10.1111/adb.12989.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsDrug useCocaine addictionFunctional connectivityPrefrontal cortical connectivityState functional connectivityReward circuit dysfunctionRecent cocaine useHealthy control participantsInferior parietal cortexCompulsive drug useHabitual drug useCircuit dysfunctionCocaine withdrawalCocaine-dependent individualsCocaine cravingCortical connectivitySignificant anxietyDorsomedial prefrontalParietal cortexCocaine useIntrinsic connectivitySubcortical hubsDrug seekingCue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving
Zhang S, Zhornitsky S, Wang W, Dhingra I, Le TM, Li CR. Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving. Drug And Alcohol Dependence 2020, 216: 108240. PMID: 32853997, PMCID: PMC7606798, DOI: 10.1016/j.drugalcdep.2020.108240.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsHabitual drug useCocaine withdrawalCocaine cravingDrug useCue exposureNeutral cue exposureReward circuit dysfunctionCocaine Craving QuestionnaireCocaine cue exposureChronic cocaine useSex differencesCocaine-dependent participantsCircuit dysfunctionFemale CDVentromedial prefrontal cortexCocaine useCocaine addictionFunctional connectivityPrefrontal cortexDependent participantsWithdrawalHigher activationCocaine
2017
Classification of Cocaine Dependents from fMRI Data Using Cluster-Based Stratification and Deep Learning
Santos J, Savii R, Ide J, Li C, Quiles M, Basgalupp M. Classification of Cocaine Dependents from fMRI Data Using Cluster-Based Stratification and Deep Learning. Lecture Notes In Computer Science 2017, 10404: 298-313. DOI: 10.1007/978-3-319-62392-4_22.Peer-Reviewed Original ResearchDeep learningDeep learning methodsDeep neural networksDeep belief networkSmall data setsComputational visionClassification of pathologiesBelief networkFMRI classificationVoice recognitionNeural networkLearning methodsRobust trainingBrain decodingSmall dataData setsLearningCocaine dependenceNovel stratification methodTraditional techniquesNetworkClassificationCocaine dependentsNon-addicted individualsDrug use
2014
Error-related functional connectivity of the thalamus in cocaine dependence
Zhang S, Hu S, Bednarski SR, Erdman E, Li CS. Error-related functional connectivity of the thalamus in cocaine dependence. NeuroImage Clinical 2014, 4: 585-592. PMID: 24936409, PMCID: PMC4053644, DOI: 10.1016/j.nicl.2014.01.015.Peer-Reviewed Original ResearchConceptsVentral medial prefrontal cortexFunctional connectivityCognitive controlGeneralized psychophysiological interaction analysisTask-related processesPsychophysiological interaction analysisSubgenual anterior cingulate cortexCocaine dependenceMedial prefrontal cortexAnterior cingulate cortexError processingExecutive functionCocaine-dependent patientsPrefrontal cortexCingulate cortexRelated activationSubstance misuseCocaine useDrug useThalamic connectivity
2013
Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence
Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM, Hong KI, Sinha R, Mazure CM, Li CS. Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 2013, 136: 1231-1244. PMID: 23485852, PMCID: PMC3613717, DOI: 10.1093/brain/awt040.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexFunctional magnetic resonance imagingCognitive controlError-related activationError processingCocaine-dependent individualsAnterior cingulate cortexSignal taskCingulate cortexCocaine dependenceFunctional magnetic resonance imaging (fMRI) dataStop-signal taskTreatment-seeking individualsCross-sectional findingsModerate-sized cohortsBrain activationBehavioral treatmentNeural predictorsDrug useMagnetic resonance imaging dataStatistical Parametric Mapping 8Regional activationPsychosocial factorsSuccess trialsMagnetic resonance imaging