Methylphenidate Modulates Functional Network Connectivity to Enhance Attention
Rosenberg MD, Zhang S, Hsu WT, Scheinost D, Finn ES, Shen X, Constable RT, Li CS, Chun MM. Methylphenidate Modulates Functional Network Connectivity to Enhance Attention. Journal Of Neuroscience 2016, 36: 9547-9557. PMID: 27629707, PMCID: PMC5039242, DOI: 10.1523/jneurosci.1746-16.2016.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderSustained attentionWhole-brain connectivity patternsFunctional brain networksHyperactivity disorderBrain networksConnectivity patternsConnectome-based predictive modeling approachWhole-brain functional connectivity patternsWhole-brain functional connectivity networksSustained attention taskStop-signal taskDose of methylphenidateFunctional network connectivityCausal roleFunctional connectivity patternsHealthy adultsAttention taskCognitive abilitiesPromising neuromarkerNetwork strengthBehavioral predictionsADHD treatmentConnectivity signaturesFunctional connectivity networksThe Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults
Kline RL, Zhang S, Farr OM, Hu S, Zaborszky L, Samanez-Larkin GR, Li CS. The Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults. Frontiers In Human Neuroscience 2016, 10: 149. PMID: 27148006, PMCID: PMC4834346, DOI: 10.3389/fnhum.2016.00149.Peer-Reviewed Original ResearchResting-state functional connectivityEffects of methylphenidateAttention deficit hyperactivity disorderLocus coeruleusPositive connectivityNegative connectivityFunctional connectivityBrain resting-state functional connectivityHealthy adultsDeficit hyperactivity disorderBasal nucleusDose of methylphenidateMiddle occipital gyrusSeed regionVTA/SNcVentral tegmental area/substantia nigraCognitive controlVentral tegmental areaHyperactivity disorderOccipital gyrusT-testCatecholaminergic signalingTwo-sample t-testMethylphenidatePrecentral gyrus