2021
Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics
Le TM, Potvin S, Zhornitsky S, Li CR. Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. Neuroscience & Biobehavioral Reviews 2021, 127: 255-269. PMID: 33933507, PMCID: PMC8411123, DOI: 10.1016/j.neubiorev.2021.04.028.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexMiddle frontal gyrusHealthy controlsLeft dorsal anterior cingulate cortexMFG activationSubstance use statusPrefrontal cortical dysfunctionAnterior cingulate cortexPrefrontal cortical regionsResponse inhibitionPopulation characteristicsImpaired task performanceInhibitory control deficitsCortical dysfunctionCerebral functionBenefits of abstinenceNicotine usersCortical activationCingulate cortexCortical regionsFrontal gyrusBrain activationDrug addictionUse statusControl deficitsMidcingulate Cortical Activations Interrelate Chronic Craving and Physiological Responses to Negative Emotions in Cocaine Addiction
Zhornitsky S, Le TM, Wang W, Dhingra I, Chen Y, Li CR, Zhang S. Midcingulate Cortical Activations Interrelate Chronic Craving and Physiological Responses to Negative Emotions in Cocaine Addiction. Biological Psychiatry Global Open Science 2021, 1: 37-47. PMID: 35664438, PMCID: PMC9164547, DOI: 10.1016/j.bpsgos.2021.03.003.Peer-Reviewed Original ResearchCD subjectsCocaine cravingMidcingulate cortexControl subjectsSkin conductance responsesBrain activationHealthy control subjectsCocaine Craving QuestionnaireCocaine-dependent subjectsInferior parietal gyrusRegional brain activationChronic cocaineParietal gyrusMotor circuitsPhysiological responsesCocaine addictionDrug cravingCravingNeutral imagesSex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
Dhingra I, Zhang S, Zhornitsky S, Wang W, Le TM, Li CR. Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neuroscience 2021, 22: 12. PMID: 33639845, PMCID: PMC7913329, DOI: 10.1186/s12868-021-00618-3.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskFunctional magnetic resonance imagingNeural responsesSex differencesReward-related brain activationBilateral orbitofrontal cortexMagnetic resonance imagingIncentive delay taskWhole-brain regressionVisual cortexResonance imagingOrbitofrontal cortexBrain activationWomenSuccess rateFMRI studyMenDelay taskImaging literatureNeural sensitivityCortexNeural basisAffective functionsHigher SR scoresLarge wins
2020
Perceived burdensomeness and neural responses to ostracism in the Cyberball task
Le TM, Zhornitsky S, Wang W, Li CR. Perceived burdensomeness and neural responses to ostracism in the Cyberball task. Journal Of Psychiatric Research 2020, 130: 1-8. PMID: 32763557, PMCID: PMC7554229, DOI: 10.1016/j.jpsychires.2020.06.015.Peer-Reviewed Original ResearchConceptsCyberball taskInterpersonal needsIndividual differencesProsocial behaviorNeural responsesSocial interactionStronger neural responsesGreater brain activationDorsomedial prefrontal cortexMiddle frontal gyrusSocial exclusionResponse timeBrain activationBrain correlatesBehavioral performanceFMRI studyAnterior insulaFrontal gyrusSocial painBehavioral avoidanceAffective responsesBehavioral measuresNeural activationPrefrontal cortexEmotional distress
2019
The effects of age on reward magnitude processing in the monetary incentive delay task
Dhingra I, Zhang S, Zhornitsky S, Le T, Wang W, Chao HH, Levy I, Li CR. The effects of age on reward magnitude processing in the monetary incentive delay task. NeuroImage 2019, 207: 116368. PMID: 31743790, PMCID: PMC7463276, DOI: 10.1016/j.neuroimage.2019.116368.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskSupplementary motor areaMagnitude of rewardAge-related differencesDelay taskRT differencesRegional activationAge effectsEffect of ageReaction time differencesRight anterior insulaMiddle frontal gyrusReward-directed behaviorExplicit cuesMagnitude processingBrain activationRight caudate headAnterior insulaFrontal gyrusReward magnitudeLarge rewardPrimary motor cortexCerebral processesParahippocampal gyrusNeural correlates of reward-directed action and inhibition of action
Le TM, Zhang S, Zhornitsky S, Wang W, Li CR. Neural correlates of reward-directed action and inhibition of action. Cortex 2019, 123: 42-56. PMID: 31747630, DOI: 10.1016/j.cortex.2019.10.007.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexInhibition of actionGo trialsReward-directed actionGoal-directed actionsInferior parietal cortexMiddle frontal cortexAnterior cingulate cortexMain effectSignificant main effectVisual attentionNeural correlatesGo taskResponse executionReward valuationNeural processesBrain activationHealthy human adultsNeural responsesReward magnitudeConjunction analysisLarge rewardDorsal ACCCingulate cortexParietal cortexPosterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking
Le TM, Zhornitsky S, Wang W, Ide J, Zhang S, Li CR. Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. Journal Of Neuroscience 2019, 39: 6354-6364. PMID: 31189577, PMCID: PMC6687909, DOI: 10.1523/jneurosci.0508-19.2019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMaladaptive coping mechanismPunishment sensitivityNeural substratesBehavioral avoidanceResponse inhibitionNegative affectAlcohol usePosterior cingulate cortex activationCoping mechanismsProblem drinkingAlcohol misusePCC responseSensation-seeking traitsAvoidance strategiesAlcohol Use Disorders Identification TestHazardous alcohol useAvoidance tendenciesAlcohol Use Disorders Identification Test (AUDIT) scoresGo taskNeural processesReward QuestionnaireAction inhibitionBrain activationCerebral correlates
2018
Motor Preparation Disrupts Proactive Control in the Stop Signal Task
Wang W, Hu S, Ide JS, Zhornitsky S, Zhang S, Yu AJ, Li CR. Motor Preparation Disrupts Proactive Control in the Stop Signal Task. Frontiers In Human Neuroscience 2018, 12: 151. PMID: 29780308, PMCID: PMC5945807, DOI: 10.3389/fnhum.2018.00151.Peer-Reviewed Original ResearchStop-signal taskGranger causal connectivityMotor preparationSignal taskMotor preparatory activityFP activationCausal connectivityMotor responseTrial reaction timeDirect neural evidenceConflict anticipationBrain activationTrialsSequential effectsSuccess rateRegional activationResponse slowingActivationPreparatory activityCertain individualsDifferent patternsHigh levelsControlSlowingNeural evidence
2016
Novelty Seeking, Harm Avoidance, and Cerebral Responses to Conflict Anticipation: An Exploratory Study
Hu J, Hu S, Maisano JR, Chao HH, Zhang S, Li CR. Novelty Seeking, Harm Avoidance, and Cerebral Responses to Conflict Anticipation: An Exploratory Study. Frontiers In Human Neuroscience 2016, 10: 546. PMID: 27857686, PMCID: PMC5093128, DOI: 10.3389/fnhum.2016.00546.Peer-Reviewed Original ResearchInferior parietal lobuleConflict anticipationProactive controlLateral orbitofrontal cortexMiddle frontal gyrusHarm avoidancePre-supplementary motor areaBilateral inferior parietal lobuleRight inferior parietal lobuleCognitive control circuitsWhole-brain linear regressionTrial reaction timeStop-signal taskRegional brain activationRight lateral orbitofrontal cortexCerebral responsesIndividual differencesSignal taskBrain activationFMRI studyTridimensional Personality QuestionnaireFrontal gyrusGreater activationHA traitExploratory studyA dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action
Manza P, Hu S, Chao HH, Zhang S, Leung HC, Li CS. A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action. NeuroImage 2016, 134: 466-474. PMID: 27126003, PMCID: PMC4912860, DOI: 10.1016/j.neuroimage.2016.04.055.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexStop-signal reaction timeAnterior cingulate cortexSignal reaction timeCingulate cortexResponse inhibitionMotor inhibitionPre-supplementary motor areaRegional activationPre-SMA functionRegional brain activationMotor response inhibitionMotor areaStop trialsSalience processingBrain activationSalience detectionSuccess trialsSignal taskTrialsInhibitionSuccessful inhibitionInfrequent stimuliCortexActivation
2015
Individual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits
Hu J, Lee D, Hu S, Zhang S, Chao H, Li CS. Individual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits. Brain Structure And Function 2015, 221: 2607-2618. PMID: 25989852, PMCID: PMC4654717, DOI: 10.1007/s00429-015-1061-4.Peer-Reviewed Original ResearchConceptsStop-signal taskHarm avoidanceNeural processesSignal taskPersonality traitsStudy of cognitionWhole-brain regressionRegional brain activationRisk-taking processesCognitive controlExecutive controlStop errorBrain activationFMRI studyBehavioral tasksMotor decisionsFrontopolar cortexMonetary rewardsNovelty seekingRisk-taking responsesBilateral orbitofrontalExplicit manipulationDorsomedial prefrontalRegional activationParahippocampal gyrus
2014
The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults
Farr OM, Zhang S, Hu S, Matuskey D, Abdelghany O, Malison RT, Li CS. The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults. The International Journal Of Neuropsychopharmacology 2014, 17: 1177-1191. PMID: 24825078, PMCID: PMC4506752, DOI: 10.1017/s1461145714000674.Peer-Reviewed Original ResearchConceptsEffects of methylphenidateResting-state connectivityFunctional connectivityResting-state functional connectivityFrontal executive areasRegional brain activationAmygdala/hippocampusPrefrontal cortical connectivityDorsal striatumHealthy adultsCognitive performanceBrain activationExecutive areasGlobal functional connectivityCatecholaminergic signalingMotor cortexBrain regionsBrain functionPrimary motor cortexCortical connectivityCerebral connectivityMemory circuitsCatecholaminergic dysfunctionMethylphenidatePsychiatric disorders
2013
Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence
Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM, Hong KI, Sinha R, Mazure CM, Li CS. Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 2013, 136: 1231-1244. PMID: 23485852, PMCID: PMC3613717, DOI: 10.1093/brain/awt040.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexFunctional magnetic resonance imagingCognitive controlError-related activationError processingCocaine-dependent individualsAnterior cingulate cortexSignal taskCingulate cortexCocaine dependenceFunctional magnetic resonance imaging (fMRI) dataStop-signal taskTreatment-seeking individualsCross-sectional findingsModerate-sized cohortsBrain activationBehavioral treatmentNeural predictorsDrug useMagnetic resonance imaging dataStatistical Parametric Mapping 8Regional activationPsychosocial factorsSuccess trialsMagnetic resonance imaging
2012
Saliency Processing and Obesity: A Preliminary Imaging Study of the Stop Signal Task
Hendrick OM, Luo X, Zhang S, Li C. Saliency Processing and Obesity: A Preliminary Imaging Study of the Stop Signal Task. Obesity 2012, 20: 1796-1802. PMID: 21720427, PMCID: PMC3653271, DOI: 10.1038/oby.2011.180.Peer-Reviewed Original ResearchConceptsStop-signal taskObese femalesBrain activationCognitive controlAltered cerebral functionSupplementary motor areaSignal taskRegional brain activationInferior parietal cortexSaliency processingCerebral functionLean femalesMotor areaFunctional magnetic resonance imagesParietal cortexSimilar behavioral performanceImaging studiesStop trialsPreliminary imaging studyObesityMagnetic resonance imagesTrialsGreater activationResonance imagesResponse inhibitionEffects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis
Chao HH, Uchio E, Zhang S, Hu S, Bednarski SR, Luo X, Rose M, Concato J, Li CS. Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis. BMC Cancer 2012, 12: 371. PMID: 22925152, PMCID: PMC3502584, DOI: 10.1186/1471-2407-12-371.Peer-Reviewed Original ResearchMeSH KeywordsAgedAndrogen AntagonistsAnilidesAntineoplastic Agents, HormonalBrainCognitionCohort StudiesGoserelinHumansMagnetic Resonance ImagingMaleMemoryMiddle AgedNeuropsychological TestsNitrilesProspective StudiesProstatic NeoplasmsPsychomotor PerformanceQuality of LifeSurveys and QuestionnairesTosyl CompoundsTreatment OutcomeConceptsAndrogen deprivation therapyFunctional magnetic resonance imagingProspective observational cohort analysisObservational cohort analysisN-back taskStop-signal taskCognitive controlProstate cancerBrain activationCohort analysisLow-risk prostate cancerNon-metastatic prostate cancerVeterans Affairs Medical CenterLong-term clinical implicationsBrain connectivityProstate cancer patientsPrefrontal cortical activationQuality of lifeFunctional brain connectivityMagnetic resonance imagingMedial prefrontal cortexParticular clinical concernDeprivation therapyADT useAndrogen deprivationDecreased saliency processing as a neural measure of Barratt impulsivity in healthy adults
Farr OM, Hu S, Zhang S, Li CS. Decreased saliency processing as a neural measure of Barratt impulsivity in healthy adults. NeuroImage 2012, 63: 1070-1077. PMID: 22885245, PMCID: PMC3472158, DOI: 10.1016/j.neuroimage.2012.07.049.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskMiddle frontal cortexCognitive controlTrait impulsivityResponse inhibitionComponent processesSaliency processingBarratt impulsivityCognitive control functionsLeft dorsolateral prefrontal cortexPost-error slowingRegional brain activationDorsolateral prefrontal cortexSignal reaction timeYoung adult participantsBarratt Impulsivity ScaleNeural measuresError processingSignal taskBrain activationPsychophysiological interactionImpulsivity scoresBIS-11Impulsivity ScaleThe effects of age on cerebral activations: internally versus externally driven processes
Hu S, Chao H, Winkler AD, Li CS. The effects of age on cerebral activations: internally versus externally driven processes. Frontiers In Aging Neuroscience 2012, 4: 4. PMID: 22536185, PMCID: PMC3334814, DOI: 10.3389/fnagi.2012.00004.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingCerebral activationRegional brain activationAge-related decreaseCognitive processesPrepotent responsesPsychological constructsCognitive functioningSignal taskBrain activationGo trialsFMRI dataGo signalSE trialsEffect of ageImaging literatureYoung adultsStop signalHealthy adultsInfluence of ageSeeming inconsistencyAdultsMagnetic resonance imagingYears of ageFunctioning
2009
A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus
Zhang S, Li CS. A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus. NeuroImage 2009, 49: 1911-1918. PMID: 19761851, PMCID: PMC2791356, DOI: 10.1016/j.neuroimage.2009.09.004.Peer-Reviewed Original ResearchConceptsBlood oxygenation level-dependent activityRegional brain activationLevel-dependent activityTask engagementNeural measuresNeural processesBrain activationPosterior cingulate cortexAttentional monitoringResponse inhibitionHuman cognitionPrefrontal activationSignal taskGreater activationBOLD activityBehavioral engagementCingulate cortexPrecuneusBrain regionsLow-frequency fluctuationsFractional amplitudeBrain imagingSeed regionIndependent component analysisEngagementActivation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time – an intra-subject analysis
Chao H, Luo X, Chang J, Li CS. Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time – an intra-subject analysis. BMC Neuroscience 2009, 10: 75. PMID: 19602259, PMCID: PMC2719646, DOI: 10.1186/1471-2202-10-75.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight inferior prefrontal cortexStop-signal taskPre-supplementary motor areaShorter stop-signal reaction timesInferior prefrontal cortexSignal reaction timePrefrontal cortexResponse inhibitionMotor areaMiddle/posterior cingulate cortexMotor response inhibitionInferior frontal cortexRegional brain activationStop-signal inhibitionLonger stop-signal reaction timesInhibitory motor controlPosterior cingulate cortexMedial prefrontal cortexReaction timeGreater activityAttentional monitoringNeural processesSignal taskBrain activationGender Differences in Cognitive Control: an Extended Investigation of the Stop Signal Task
Li CS, Zhang S, Duann JR, Yan P, Sinha R, Mazure CM. Gender Differences in Cognitive Control: an Extended Investigation of the Stop Signal Task. Brain Imaging And Behavior 2009, 3: 262-276. PMID: 19701485, PMCID: PMC2728908, DOI: 10.1007/s11682-009-9068-1.Peer-Reviewed Original ResearchRegional brain activationTrial reaction timeStop-signal taskCognitive controlBrain activationGo-trial reaction timesRight inferior parietal lobuleGender differencesReaction timeSub-cortical areasInferior parietal lobuleFunctional magnetic resonancePost-SEClinical conditionsControl disordersCortical activationClinical implicationsParietal lobuleInitiate studiesResponse inhibitionNeural processesSignal taskGreater activationWomenMen