2011
Therapeutic and prognostic importance of epithelial–mesenchymal transition in liver cancers: Insights from experimental models
Ogunwobi O, Liu C. Therapeutic and prognostic importance of epithelial–mesenchymal transition in liver cancers: Insights from experimental models. Critical Reviews In Oncology/Hematology 2011, 83: 319-328. PMID: 22178416, DOI: 10.1016/j.critrevonc.2011.11.007.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionHepatocellular carcinomaHepatic metastasesPrognostic importanceExperimental modelColon cancerTreatment of patientsRole of EMTHuman cancer patientsPotential therapeutic targetHuman malignant diseaseSignificant morbidityCancer patientsMalignant diseaseMalignant conditionsLiver cancerTherapeutic targetBasic scientistsCancerFurther studiesPatientsCarcinomaMetastasisLiverHuman tissues
2009
DNMT1 and DNMT3B Modulate Distinct Polycomb-Mediated Histone Modifications in Colon Cancer
Jin B, Yao B, Li J, Fields C, Delmas A, Liu C, Robertson K. DNMT1 and DNMT3B Modulate Distinct Polycomb-Mediated Histone Modifications in Colon Cancer. Cancer Research 2009, 69: 7412-7421. PMID: 19723660, PMCID: PMC2745494, DOI: 10.1158/0008-5472.can-09-0116.Peer-Reviewed Original ResearchConceptsDNA methyltransferasesMethylation patternsPolycomb group targetsPRC1/PRC2DNA methylation patternsBisulfite genomic sequencingPRC1 functionRepression complexHistone codeHistone modificationsChromatin immunoprecipitationEpigenetic silencingPanel of genesEpigenetic modifiersReverse transcription-PCRPRC2DNMT3BNovel linkGenomic sequencingGenesDNMT1Colorectal cancer cell linesCell growthCancer cell linesPRC1