2020
Development and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia
Wu C, Luedtke A, Sadikova E, Tsai H, Liao S, Liu C, Gau S, VanderWeele T, Kessler R. Development and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia. JAMA Network Open 2020, 3: e1921660. PMID: 32083693, PMCID: PMC7043195, DOI: 10.1001/jamanetworkopen.2019.21660.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaAntipsychotic medicationPrescribed antipsychotic medicationTreatment success rateTreatment successSchizophrenic disordersFirst-episodeSuccess rateSchizophreniaProbability of treatment successTaiwan National Health Insurance Research DatabaseNational Health Insurance Research DatabaseHealth Insurance Research DatabaseEstimating treatment successValidation sampleIndividualized treatment rulesMedicationPrognostic studyPatientsInvestigated biomarkersClinical implementationDischarge diagnosisClinical observationsDemographic dataPragmatic trial
2019
Social cognition in schizophrenia: A network-based approach to a Taiwanese version of the Reading the Mind in the Eyes test
Li T, Liu C, Liu C, Hsieh M, Lin Y, Wang E, Hwang T, Chou T. Social cognition in schizophrenia: A network-based approach to a Taiwanese version of the Reading the Mind in the Eyes test. Journal Of The Formosan Medical Association 2019, 119: 439-448. PMID: 31558338, DOI: 10.1016/j.jfma.2019.08.008.Peer-Reviewed Original ResearchConceptsEyes TestNegative emotionsMental statesHealthy controlsSocial cognitive impairmentsChoice patternsStructure of mental statesTaiwanese versionBlunted affectEmotional withdrawalSocial cognitionSocial withdrawalAspect of theoryNegative wordsSchizophreniaEmotionsHigh centralityEmotional aspectsReaction timePoor performanceControl groupImpairmentWithdrawalPatient groupCognitionAJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN
Fan Z, Cheng H, Jin K, Gong Y, Huang Q, Xu J, Ni Q, Yu X, Liu C, Luo G. AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN. World Journal Of Surgical Oncology 2019, 17: 137. PMID: 31387646, PMCID: PMC6685146, DOI: 10.1186/s12957-019-1682-9.Peer-Reviewed Original ResearchConceptsInvasive IPMNInvasive intraductal papillary mucinous neoplasmStage IB diseaseStage IIA diseaseHazard ratioEdition classificationIIA diseaseIB diseaseStaging classificationStaging systemEnd Results cancer registryIntraductal papillary mucinous neoplasmEdition staging systemPredictors of survivalAmerican Joint CommitteeCancer (AJCC) staging systemPapillary mucinous neoplasmConclusionsThe AJCCResectable tumorsAJCC stagingStage IIACancer RegistryTumor sizeMucinous neoplasmsResultsIn total
2018
Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia
Huang J, Liu C, Hwang T, Chen Y, Hsu Y, Hwu H, Lin Y, Hsieh M, Liu C, Chien Y, Tseng W. Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia. Human Brain Mapping 2018, 39: 2007-2019. PMID: 29377322, PMCID: PMC6866389, DOI: 10.1002/hbm.23982.Peer-Reviewed Original ResearchConceptsGeneralized fractional anisotropyGeneralized fractional anisotropy valuesAdequate antipsychotic treatmentNegative symptom scoresNonremission groupWhite matter tract integrityWhite matter integrityHealthy controlsRemission stateWhite matter tract bundlesWhite matter tractsReduced integrationAntipsychotic treatmentNonremitted patientsSchizophrenia patientsSymptomatic remissionIllness durationAnalysis of covarianceSchizophreniaDiffusion spectrum imagingTract integrityPost hoc analysisFractional anisotropyMedication dosesEducation years
2017
Seroprevalence survey of selective anti-neuronal autoantibodies in patients with first-episode schizophrenia and chronic schizophrenia
Chen C, Cheng M, Liu C, Liu C, Lin K, Hwu H. Seroprevalence survey of selective anti-neuronal autoantibodies in patients with first-episode schizophrenia and chronic schizophrenia. Schizophrenia Research 2017, 190: 28-31. PMID: 28341002, DOI: 10.1016/j.schres.2017.03.012.Peer-Reviewed Original ResearchConceptsAnti-neuronal autoantibodiesLeucine-rich glioma-inactivated-1N-methyl-D-aspartateContactin-associated protein-like 2First-episode schizophreniaAnti-NMDA receptor autoantibodiesA-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidAssociated with psychiatric disordersGlioma-inactivated-1Blood samplesNeuronal cell surface proteinsArchived blood samplesNeuronal surface proteinsCerebral spinal fluidProtein-like 2Chronic schizophreniaReceptor autoantibodiesClinical presentationAutoimmune encephalopathyTreatment resistancePsychiatric disordersCorrect diagnosisSchizophreniaAutoantibodiesSpinal fluid
2016
Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits
Liu Y, Wang S, Hwu H, Fann C, Yang U, Yang W, Hsu P, Chang C, Wen C, Tsai-Wu J, Hwang T, Hsieh M, Liu C, Chien Y, Fang C, Faraone S, Tsuang M, Chen W, Liu C. Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits. PLOS ONE 2016, 11: e0150435. PMID: 26986737, PMCID: PMC4795637, DOI: 10.1371/journal.pone.0150435.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsAssociated with schizophreniaIntron 8Genomic regionsIntron 1Genetic variantsLarger patient samplesD-amino-acid oxidase geneNovel single‐nucleotide polymorphismsHaplotype association analysisSingle-locus analysisExecutive functionD-amino acid oxidaseFunctional genetic variantsSustained attentionNeurocognitive functionSchizophreniaEpstein-Barr virus-transformed lymphocytesMRNA expressionHaplotype blocksSingle-locusHaplotype distributionVirus-transformed lymphocytesHaplotype frequenciesAssociation analysisImpact of universal health coverage on urban–rural inequity in psychiatric service utilisation for patients with first admission for psychosis: a 10-year nationwide population-based study in Taiwan
Chiang C, Chen P, Huang L, Kuo P, Tung Y, Liu C, Chen W. Impact of universal health coverage on urban–rural inequity in psychiatric service utilisation for patients with first admission for psychosis: a 10-year nationwide population-based study in Taiwan. BMJ Open 2016, 6: e010802. PMID: 26940114, PMCID: PMC4785302, DOI: 10.1136/bmjopen-2015-010802.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmbulatory CareDatabases, FactualFemaleHealthcare DisparitiesHumansKaplan-Meier EstimateLogistic ModelsMaleMental Health ServicesMiddle AgedNational Health ProgramsPatient AdmissionPsychotic DisordersRetrospective StudiesRural PopulationTaiwanUniversal Health InsuranceUrban PopulationYoung AdultConceptsUniversal health coverageService utilisationUrban-rural residenceUrban-rural inequalitiesHealth coverageUrban patientsEmergency departmentImplementation of universal health coverageImpacts of universal health coverageNationwide population-based studyQuality of careTaiwan National Health Insurance Research DatabaseNational Health Insurance Research DatabaseRural-dwelling patientsHealth Insurance Research DatabasePopulation-based studyUrban-rural differencesPopulation coverage ratePsychiatric outpatient servicesMedical claims recordsNationwide cohort of patientsRisk of readmissionRural patientsUrban-rural gapPsychiatric readmissionAberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue
Lai C, Lee S, Scarr E, Yu Y, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Udawela M, Gibbons A, Everall I, Hwu H, Dean B, Chen W. Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue. Translational Psychiatry 2016, 6: e717-e717. PMID: 26784971, PMCID: PMC5068884, DOI: 10.1038/tp.2015.213.Peer-Reviewed Original ResearchConceptsPeripheral miRNAsState-dependent markersDiagnostic of schizophreniaHsa-miR-34aPostmortem brain tissueAberrant expression of microRNAsCaudate putamenSchizophreniaSubcortical regionsAcute stateExpression of microRNAsSeven-miRNARemission stateBrain samplesAberrant expressionClinically useful biomarkersExpression levelsBrainMonths of hospitalizationPartial remission stateAge-dependent increaseMiRNA dysregulationMiRNAsPartial remissionClinical symptoms
2015
Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis
Liu C, Hua M, Hwang T, Chiu C, Liu C, Hsieh M, Chien Y, Lin Y, Hwu H. Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis. Schizophrenia Research 2015, 164: 40-46. PMID: 25802138, DOI: 10.1016/j.schres.2015.03.006.Peer-Reviewed Original ResearchConceptsUltra-high riskPre-psychotic stateNeurocognitive functionWechsler Adult Intelligence Scale-Third EditionWechsler Memory Scale-Third EditionRisk of transition to psychosisWisconsin Card Sorting TestCard Sorting TestDomains of neurocognitionNeurocognitive function of patientsTransition to psychosisContinuous Performance TestVerbal fluency testTrail Making TestLevels of clinical severityFollow-up assessmentStability of changesSorting TestNeuropsychological batteryOnset of illnessNeurocognitive profileEpisode psychosisFluency testNeurocognitive deficitsFunction of subjects
2014
The combination of HTATIP2 expression and microvessel density predicts converse survival of hepatocellular carcinoma with or without sorafenib
Wang W, Liu L, Xu H, Sun H, Wu C, Zhu X, Zhang W, Xu J, Liu C, Long J, Ni Q, Tang Z, Yu X. The combination of HTATIP2 expression and microvessel density predicts converse survival of hepatocellular carcinoma with or without sorafenib. Oncotarget 2014, 5: 3895-3906. PMID: 25008315, PMCID: PMC4116529, DOI: 10.18632/oncotarget.2019.Peer-Reviewed Original ResearchConceptsSurvival of hepatocellular carcinomaMicrovessel densityHepatocellular carcinomaSorafenib treatmentDissemination of hepatocellular carcinomaAssociated with inhibition of angiogenesisAdvanced hepatocellular carcinomaMicrovessel density valuesCurative HCC resectionSuppressor of tumor growthInhibition of angiogenesisNegative prognostic indicatorAssociated with inhibitionSorafenib interventionHCC resectionSorafenib administrationOverall survivalDisease recurrencePrognostic factorsTissue microarrayPrognostic indicatorTumor growthSorafenibPersonalized treatmentPredictive value
2013
Aripiprazole for Drug-Naive or Antipsychotic-Short-Exposure Subjects With Ultra-High Risk State and First-Episode Psychosis
Liu C, Chien Y, Hsieh M, Hwang T, Hwu H, Liu C. Aripiprazole for Drug-Naive or Antipsychotic-Short-Exposure Subjects With Ultra-High Risk State and First-Episode Psychosis. Journal Of Clinical Psychopharmacology 2013, 33: 18-23. PMID: 23277261, DOI: 10.1097/jcp.0b013e31827cb017.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisUltra-high riskFirst-episode psychosis patientsDrug-naiveUltra-high risk stateUltra-high-risk patientsLow-dose aripiprazoleNegative symptom scoresPositive symptom scoresFlexible dosing strategyState of psychosisTreatment responseAntipsychotic therapyDrug-naive populationSevere psychopathologyUHR patientsFirst-episodeAripiprazoleAdverse eventsSymptom scoresPsychosisRisk stateConcomitant medicationsTarget doseClinical improvement
2012
Zotepine-related myopathy in a patient with schizophrenia
Chen I, Hsieh M, Hwang T, Liu C. Zotepine-related myopathy in a patient with schizophrenia. European Journal Of Clinical Pharmacology 2012, 69: 725-726. PMID: 22797903, DOI: 10.1007/s00228-012-1346-y.Peer-Reviewed Original ResearchHepatocyte Paraffin 1 Antigen as a Biomarker for Early Diagnosis of Barrett Esophagus
Jeung J, Coran J, Liu C, Cardona D. Hepatocyte Paraffin 1 Antigen as a Biomarker for Early Diagnosis of Barrett Esophagus. American Journal Of Clinical Pathology 2012, 137: 111-120. PMID: 22180484, PMCID: PMC3806975, DOI: 10.1309/ajcpyobvgs4cga8y.Peer-Reviewed Original ResearchConceptsBarrett's esophagusBE casesMorphologic changesIntestinal differentiationReflux esophagitis casesSmall intestinal differentiationMetaplastic reactionCertain morphologic changesClinicopathologic featuresIntestinal metaplasiaAntigen expressionEarly diagnosisSensitive markerBiopsy casesGoblet cellsMorphologic featuresRE casesEsophagusExpressionMetaplasiaHepPar1CasesInjuryAntigenDiagnosis
2010
Follow-up of subjects with suspected pre-psychotic state in Taiwan
Liu C, Lai M, Liu C, Chiu Y, Hsieh M, Hwang T, Chien Y, Chen W, Hua M, Hsiung P, Huang Y, Hwu H. Follow-up of subjects with suspected pre-psychotic state in Taiwan. Schizophrenia Research 2010, 126: 65-70. PMID: 21112187, DOI: 10.1016/j.schres.2010.10.028.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisPre-psychotic stateUHR subjectsRate of conversion to psychosisUltra-high-risk groupConversion to psychosisPsychosis risk syndromeFollow-upRisk groupsIntermediate-risk groupNegative symptomsSchizophreniform disorderSchizoaffective disorderPsychotic disordersAntipsychotic useBipolar disorderClinical interviewFollow-up of subjectsOutcomes of subjectsCommunity-based populationRisk syndromeDiagnostic categoriesPsychosisClinical attentionUHRCreating a Platform to Bridge Service and Research for Early Psychosis
Liu C, Hwu H, Chiu Y, Lai M, Tseng H. Creating a Platform to Bridge Service and Research for Early Psychosis. Journal Of The Formosan Medical Association 2010, 109: 543-549. PMID: 20654794, DOI: 10.1016/s0929-6646(10)60089-7.Peer-Reviewed Original ResearchConceptsFull-blown psychosisRisk subjectsPsychopathology progressProspective studyEarly psychosisPerceptual disturbancesLongitudinal prospective studyPsychosisIdentification of subjectsStudy teamEarly identification of subjectsYear oldsEarly interventionClinical entityClinical severityClinicRiskSubjectsAppointmentInterventionYearsIll-definedTeamEnrollment