mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers.
Li F, Guo E, Huang J, Lu F, Yang B, Xiao R, Liu C, Wu X, Fu Y, Wang Z, Peng S, Lei Y, Guo Z, Li L, Xi L, Sun C, Liu S, Chen G. mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers. American Journal Of Cancer Research 2020, 10: 908-924. PMID: 32266099, PMCID: PMC7136919.Peer-Reviewed Original ResearchEpithelial ovarian cancerOvarian cancerReplication stressWEE1 inhibitorSynergistically inhibited tumor growthOvarian cancer cell linesCombination of Wee1Patient-derived xenograftsDNA replication stressHeterogeneity of patient tumorsOvarian cancer cellsActivated mTOR pathwaySubstrate dNTPCheckpoint deficiencyTP53 mutationsCancer cell linesPatient tumorsClinical efficacyFork stallingTumor growthCell cycleTherapeutic windowDrug combinationsWEE1 inhibitionG2/M checkpoint