2014
Epigenetic regulation of OPA1 sensitizes hepatocellular carcinoma to sorafenib‐induced apoptosis (59.1)
Puszyk W, Dong H, Zhao F, Shisgal P, Cabrera R, Neslon D, Liu C. Epigenetic regulation of OPA1 sensitizes hepatocellular carcinoma to sorafenib‐induced apoptosis (59.1). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.59.1.Peer-Reviewed Original ResearchDNA methylationHepatocellular carcinomaEpigenetic regulationProtein OPA1HCC cellsMitochondrial fragmentationGene promoterC releaseEpigenetic analysisXenograft tumor growthEpigenetic markersSorafenib-induced apoptosisAkt pathwayOPA1HCC xenograft tumor growthHepatocellular carcinoma cellsNovel therapeutic targetExpression levelsTumorigenesis of HCCIdentification of patientsPathogenesis of HCCOPA1 knockdownApoptosisPrimary hepatocytesSensitivity of HCC
2009
Primary Human Hepatocyte Culture for HCV Study
Zhu H, Elyar J, Foss R, Hemming A, Hall E, LeCluyse E, Liu C. Primary Human Hepatocyte Culture for HCV Study. Methods In Molecular Biology 2009, 510: 373-382. PMID: 19009276, DOI: 10.1007/978-1-59745-394-3_28.Peer-Reviewed Original ResearchConceptsHuman primary hepatocytesAntiviral researchPrimary hepatocyte culturesHuman primary hepatocyte culturesSmall animal modelsPrimary hepatocytesHepatocyte culturesPrimary human hepatocyte culturesHCV infectionHCV pathogenesisLiver perfusionHuman hepatocyte culturesHCV researchHost-virus interactionsInfectious virusHCV studiesPrimary culturesCell model systemHepatocyte isolationHepatocytesJFH1PathogenesisPerfusionInfection