Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis
Wu C, Hwang T, Chen Y, Hsu Y, Lo Y, Liu C, Hwu H, Liu C, Hsieh M, Chien Y, Chen C, Tseng W. Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis. Schizophrenia Research 2015, 169: 54-61. PMID: 26443482, DOI: 10.1016/j.schres.2015.09.023.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexBilateral DLPFCFirst-episode patientsWhite matter connectivityFirst-episodeChronic patientsBilateral dorsolateral prefrontal cortexFirst-episode schizophreniaWidespread white matter abnormalitiesBilateral temporal polesDebilitating mental disorderReduced white matter connectivityRight arcuate fasciculusSuperior longitudinal fasciculus IDuration of illnessAssociated with clinical variablesCallosal fibersBetween-group analysisWhite matter tractsWhite matter abnormalitiesPrefrontal cortexImpaired connectivityTemporal poleArcuate fasciculusCerebral white matter