A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
Hildebrandt G, Duffner U, Olkiewicz K, Corrion L, Willmarth N, Williams D, Clouthier S, Hogaboam C, Reddy P, Moore B, Kuziel W, Liu C, Yanik G, Cooke K. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood 2003, 103: 2417-2426. PMID: 14615370, DOI: 10.1182/blood-2003-08-2708.Peer-Reviewed Original ResearchConceptsMonocyte chemoattractant protein-1Idiopathic pneumonia syndromeAllogeneic bone marrow transplantationBone marrow transplantationChemokine receptor 2CCR2/MCPAllo-BMTPneumonia syndromeMarrow transplantationBronchoalveolar lavage fluid cellularityExperimental Idiopathic Pneumonia SyndromeBAL fluid levelsMouse BMT modelSoluble p55 TNF receptorTime of diagnosisPreliminary clinical findingsChemoattractant protein-1P55 TNF receptorDonor leukocytesLung injuryMajor complicationsAllogeneic recipientsBAL fluidLethal complicationPulmonary expression