2012
Influence of Donor Microbiota on the Severity of Experimental Graft-versus-Host-Disease
Tawara I, Liu C, Tamaki H, Toubai T, Sun Y, Evers R, Nieves E, Mathewson N, Nunez G, Reddy P. Influence of Donor Microbiota on the Severity of Experimental Graft-versus-Host-Disease. Transplantation And Cellular Therapy 2012, 19: 164-168. PMID: 22982686, PMCID: PMC3529780, DOI: 10.1016/j.bbmt.2012.09.001.Peer-Reviewed Original ResearchConceptsSeverity of GVHDDonor microbiotaHost diseaseT cellsT cell-mediated alloresponsesGerm-free donorsSeverity of graftAlloreactive T cellsRelevant murine modelImmune responseMurine modelRecipient microbiotaExperimental graftGVHDSeverityMicrobiotaRecent dataGraftMicrobial floraAlloresponsesCellsDiseaseRegulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
Jenq R, Ubeda C, Taur Y, Menezes C, Khanin R, Dudakov J, Liu C, West M, Singer N, Equinda M, Gobourne A, Lipuma L, Young L, Smith O, Ghosh A, Hanash A, Goldberg J, Aoyama K, Blazar B, Pamer E, van den Brink M. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. Journal Of Experimental Medicine 2012, 209: 903-911. PMID: 22547653, PMCID: PMC3348096, DOI: 10.1084/jem.20112408.Peer-Reviewed Original ResearchConceptsAllogeneic bone marrow transplantationBone marrow transplantationIntestinal inflammationMarrow transplantationAllogeneic BMT recipientsPotential risk factorsSubsequent GVHDHost diseaseBMT recipientsRisk factorsGVHDMouse modelResident gut microbesInflammationIntestinal microbiotaSignificant protectionGut floraHuman recipientsHuman floraInitial onsetGut microbesLongitudinal studyTransplantationMicrobiotaMice
2011
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Kostic A, Gevers D, Pedamallu C, Michaud M, Duke F, Earl A, Ojesina A, Jung J, Bass A, Tabernero J, Baselga J, Liu C, Shivdasani R, Ogino S, Birren B, Huttenhower C, Garrett W, Meyerson M. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Research 2011, 22: 292-298. PMID: 22009990, PMCID: PMC3266036, DOI: 10.1101/gr.126573.111.Peer-Reviewed Original ResearchConceptsColorectal carcinomaColorectal carcinoma pathogenesisColorectal tumorsCarcinomaTumor microenvironmentTumor/normal pairsNonneoplastic cellsCancer cellsWhole genome sequencesPrecise roleTumorsMicrobiotaRDNA sequence analysisQuantitative PCRFurther investigationComplex communitiesGenome sequenceGenomic analysisSequence analysisFirmicutes phylumFusobacteriaNormal pairsCellsDiverse collectionDNA pairs