2012
Glypican‐3 as a Potential Therapeutic Target for Hepatocellular Carcinoma Immunotherapy
Trinh T, Liu C. Glypican‐3 as a Potential Therapeutic Target for Hepatocellular Carcinoma Immunotherapy. The FASEB Journal 2012, 26: 405.1-405.1. DOI: 10.1096/fasebj.26.1_supplement.405.1.Peer-Reviewed Original ResearchHCC cell linesDifferent HCC cell linesGlypican-3Hepatocellular carcinomaTherapeutic targetCell linesNon-tumor liver tissuesHepatocellular Carcinoma ImmunotherapyCell proliferationNovel therapeutic targetPotential therapeutic targetCancer cell proliferationInhibited cell proliferationDose-dependent mannerAnti-GPC3 antibodiesHuman HCC tissuesNormal primary hepatocytesHCC immunotherapyCell surface heparinGPC3 expressionHCC tissuesLiver tissueImmunotherapyWestern blotHuman tumors
2008
Repopulation of human hepatocytes in immunodeficient mice
Liu C, Witek R, Bess J, Zhu H, Lin P. Repopulation of human hepatocytes in immunodeficient mice. The FASEB Journal 2008, 22: 465.4-465.4. DOI: 10.1096/fasebj.22.1_supplement.465.4.Peer-Reviewed Original ResearchHuman hepatitis C virusHuman hepatocytesHepatitis C virusTime of hepatectomyHumanized mouse modelHuman liver diseaseRepopulation efficiencyLiver diseaseC virusHepatocyte repopulationImmunodeficient miceMouse modelTransgenic miceLiver tissueHepatocyte proliferationPartial hepatectomyMiceSerum samplesMonocrotalineMouse liverHepatectomyHepatocytesDiseaseLiverProtein markers
2007
The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1
Butler S, Dong H, Cardona D, Jia M, Zheng R, Zhu H, Crawford J, Liu C. The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1. Laboratory Investigation 2007, 88: 78-88. PMID: 18026163, DOI: 10.1038/labinvest.3700699.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigensBase SequenceBlotting, WesternCarbamoyl-Phosphate Synthase (Ammonia)Chromatography, LiquidDNA PrimersFemaleHumansImmunoprecipitationLiver NeoplasmsMaleReverse Transcriptase Polymerase Chain ReactionSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryConceptsHep Par 1 antibodyHep Par 1Carbamoyl phosphate synthetase 1Carcinoma cell linesHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePAR-1Cell linesHepatocyte paraffin 1Small intestinal tissueSurgical pathology practiceCPS1 expressionMurine monoclonal antibodiesHepatoid tumorsHuman liver tissueHepatocellular originIntestinal tissueRate-limiting enzymeLiver carcinogenesisSynthetase 1Liver tissuePathology practiceAntigenLiver pathobiologyMonoclonal antibodiesHepatocellular carcinoma arising from ectopic liver tissue in the pancreas
Cardona D, Grobmyer S, Crawford J, Liu C. Hepatocellular carcinoma arising from ectopic liver tissue in the pancreas. Virchows Archiv 2007, 450: 225-229. PMID: 17216188, DOI: 10.1007/s00428-006-0353-8.Peer-Reviewed Original ResearchConceptsEctopic liver tissueHepatocellular carcinomaLiver tissuePolyclonal carcinoembryonic antigenPreoperative fine-needle aspirationChronic pancreatic diseaseRight upper quadrantFine-needle aspirationAlpha-1 antitrypsinAbdominal painDistal pancreasDistal pancreatectomyDay historyLiver diseaseUpper quadrantHepatocyte antigenNeuroendocrine tumorsHepatoid cellsCanalicular patternNeedle aspirationPancreatic diseaseImmunohistochemistry studiesTrabecular patternGross examinationHispanic men
2000
Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections
Guo J, Zhou H, Liu C, Aldrich C, Saputelli J, Whitaker T, Barrasa M, Mason W, Seeger C. Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections. Journal Of Virology 2000, 74: 1495-1505. PMID: 10627561, PMCID: PMC111485, DOI: 10.1128/jvi.74.3.1495-1505.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDNA, ViralHepatitis BHepatitis B Virus, WoodchuckHepatitis B, ChronicInterferon-gammaLiverLiver RegenerationMarmotaMolecular Sequence DataReverse Transcriptase Polymerase Chain ReactionTumor Necrosis Factor-alphaViremiaConceptsRegeneration of hepatocytesHepadnavirus infectionTransient infectionHepatitis B virus infectionTumor necrosis factor alphaTransient hepadnavirus infectionsB virus infectionT cell accumulationNecrosis factor alphaCytokine expressionInfected hepatocytesFactor alphaT cellsVirus infectionInterferon gammaInfected liverHistologic analysisLiver tissueInfectionRecovery periodSignificant increaseHepatocytesInitial influxUnknown mechanismApoptosis