2012
Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer
Meng L, Yang L, Zhao X, Zhang L, Zhu H, Liu C, Tan W. Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer. PLOS ONE 2012, 7: e33434. PMID: 22558072, PMCID: PMC3338807, DOI: 10.1371/journal.pone.0033434.Peer-Reviewed Original ResearchConceptsAptamer-drug conjugatesCancer-specific aptamersAntitumor agent doxorubicinDOX conjugatesIntercalation methodAptamerCell viability testTargeted deliveryConjugatesCancer cellsTarget proteinsAgent doxorubicinPotential candidateCell linesDOXEfficiency of chemotherapyLiver cancer cellsNonspecific uptakeTarget specificityAvailable aptamersCarcinoma cell linesChemotherapy agentsHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePromising method
2007
The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1
Butler S, Dong H, Cardona D, Jia M, Zheng R, Zhu H, Crawford J, Liu C. The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1. Laboratory Investigation 2007, 88: 78-88. PMID: 18026163, DOI: 10.1038/labinvest.3700699.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigensBase SequenceBlotting, WesternCarbamoyl-Phosphate Synthase (Ammonia)Chromatography, LiquidDNA PrimersFemaleHumansImmunoprecipitationLiver NeoplasmsMaleReverse Transcriptase Polymerase Chain ReactionSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryConceptsHep Par 1 antibodyHep Par 1Carbamoyl phosphate synthetase 1Carcinoma cell linesHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePAR-1Cell linesHepatocyte paraffin 1Small intestinal tissueSurgical pathology practiceCPS1 expressionMurine monoclonal antibodiesHepatoid tumorsHuman liver tissueHepatocellular originIntestinal tissueRate-limiting enzymeLiver carcinogenesisSynthetase 1Liver tissuePathology practiceAntigenLiver pathobiologyMonoclonal antibodies